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Erschienen in: Archives of Gynecology and Obstetrics 5/2021

02.01.2021 | General Gynecology

Effects of epigallocatechin gallate-enriched green tea extract capsules in uterine myomas: results of an observational study

verfasst von: Rebekka Biro, Rolf Richter, Miriam Ortiz, Jalid Sehouli, Matthias David

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 5/2021

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Abstract

Purpose

The daily ingestion of green tea extract (GTE) capsules in women with oligo- or asymptomatic uterine myomas was monitored over 6 months with regard to their quality of life, myoma-associated complaints and side effects.

Methods

The participants were interviewed and examined at the beginning of the study (T1) and then again after 6 months (T3). Quality of life was assessed using a SF-12 questionnaire while their myoma-associated complaints were ascertained by using a self-developed myoma symptom questionnaire. Changes in the size of the myomas were evaluated by vaginal sonography. Side effects after 3 months (T2) and 6 months were documented by systematic interviews.

Results

Overall; 25 participants (median 45 years) have been enrolled. The analysis of the SF-12 questionnaire showed a significant improvement of the physical cumulative score of the SF-12 during the 6 month GTE capsule ingestion (T1: mean value (M) = 52.731; 95% confidence interval (KI95%): 49.791–55.671; T3: M = 55.862; KI95%%: 55.038–56.685; p = 0.019). However, the mental cumulative score of the SF-12 did not change significantly (p = 0.674). No significant correlation could be established between the capsule ingestion and changes in the symptom questionnaire, the laboratory parameters nor the myoma size. No relevant adverse side effects were reported.

Conclusion

Women who took GTE capsules showed a significant improvement in their physical cumulative score on the SF-12, but not in the global QoL score. Myoma size or other objective parameters did not change.
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Metadaten
Titel
Effects of epigallocatechin gallate-enriched green tea extract capsules in uterine myomas: results of an observational study
verfasst von
Rebekka Biro
Rolf Richter
Miriam Ortiz
Jalid Sehouli
Matthias David
Publikationsdatum
02.01.2021
Verlag
Springer Berlin Heidelberg
Erschienen in
Archives of Gynecology and Obstetrics / Ausgabe 5/2021
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-020-05907-6

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