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02.01.2021 | General Gynecology | Ausgabe 5/2021

Archives of Gynecology and Obstetrics 5/2021

Effects of epigallocatechin gallate-enriched green tea extract capsules in uterine myomas: results of an observational study

Zeitschrift:
Archives of Gynecology and Obstetrics > Ausgabe 5/2021
Autoren:
Rebekka Biro, Rolf Richter, Miriam Ortiz, Jalid Sehouli, Matthias David
Wichtige Hinweise
Jalid Sehouli and Matthias David shared senior-authorships.

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Abstract

Purpose

The daily ingestion of green tea extract (GTE) capsules in women with oligo- or asymptomatic uterine myomas was monitored over 6 months with regard to their quality of life, myoma-associated complaints and side effects.

Methods

The participants were interviewed and examined at the beginning of the study (T1) and then again after 6 months (T3). Quality of life was assessed using a SF-12 questionnaire while their myoma-associated complaints were ascertained by using a self-developed myoma symptom questionnaire. Changes in the size of the myomas were evaluated by vaginal sonography. Side effects after 3 months (T2) and 6 months were documented by systematic interviews.

Results

Overall; 25 participants (median 45 years) have been enrolled. The analysis of the SF-12 questionnaire showed a significant improvement of the physical cumulative score of the SF-12 during the 6 month GTE capsule ingestion (T1: mean value (M) = 52.731; 95% confidence interval (KI95%): 49.791–55.671; T3: M = 55.862; KI95%%: 55.038–56.685; p = 0.019). However, the mental cumulative score of the SF-12 did not change significantly (p = 0.674). No significant correlation could be established between the capsule ingestion and changes in the symptom questionnaire, the laboratory parameters nor the myoma size. No relevant adverse side effects were reported.

Conclusion

Women who took GTE capsules showed a significant improvement in their physical cumulative score on the SF-12, but not in the global QoL score. Myoma size or other objective parameters did not change.

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