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Erschienen in: European Journal of Applied Physiology 5/2019

19.02.2019 | Original Article

Effects of exercise in normobaric hypoxia on hemodynamics during muscle metaboreflex activation in normoxia

verfasst von: Gabriele Mulliri, Gianmarco Sainas, Sara Magnani, Silvana Roberto, Giovanna Ghiani, Mauro Mannoni, Virginia Pinna, Sarah J. Willis, Grégoire P. Millet, Azzurra Doneddu, Antonio Crisafulli

Erschienen in: European Journal of Applied Physiology | Ausgabe 5/2019

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Abstract

Purpose

Little is known about the cardiovascular effects of the transition from exercise in hypoxia (EH) to normoxia. This investigation aimed to assess hemodynamics during the metaboreflex elicited in normoxia after EH.

Methods

Ten trained athletes (four females and six males, age 35.6 ± 8.4 years) completed a cardiopulmonary test to determine the workload at anaerobic threshold (AT). On separate days, participants performed three randomly assigned exercise sessions (10 min pedalling at 80% of AT): (1) one in normoxia (EN); (2) one in normobaric hypoxia with FiO2 15.5% (EH15.5%); and (3) one in normobaric hypoxia with FiO2 13.5% (EH13.5%). After each session, the following protocol was randomly assigned: either (1) post-exercise muscle ischemia after cycling for 3 min, to study the metaboreflex, or (2) a control exercise recovery (CER) session, without any metaboreflex stimulation.

Results

The main result were that both EH15.5% and EH13.5% impaired (p < 0.05) the ventricular filling rate response during the metaboreflex (− 18 ± 32 and − 20 ± 27 ml s−1), when compared to EN (+ 29 ± 32 ml s−1), thereby causing a reduction in stroke volume response (− 9.1 ± 3.2, − 10.6 ± 8.7, and + 5 ± 5.7 ml for EH15.5%, EH13.5% and EN test, respectively, p < 0.05). Moreover, systemic vascular resistance was increased after the EH15.5% and the EH13.5% in comparison with the EN test.

Conclusions

These data demonstrate that moderate exercise in hypoxia impairs the capacity to enhance venous return during the metaboreflex stimulated in normoxia. Overall, there is a functional shift from a flow to vasoconstriction-mediated mechanism for maintaining the target blood pressure during the metaboreflex.
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Metadaten
Titel
Effects of exercise in normobaric hypoxia on hemodynamics during muscle metaboreflex activation in normoxia
verfasst von
Gabriele Mulliri
Gianmarco Sainas
Sara Magnani
Silvana Roberto
Giovanna Ghiani
Mauro Mannoni
Virginia Pinna
Sarah J. Willis
Grégoire P. Millet
Azzurra Doneddu
Antonio Crisafulli
Publikationsdatum
19.02.2019
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Applied Physiology / Ausgabe 5/2019
Print ISSN: 1439-6319
Elektronische ISSN: 1439-6327
DOI
https://doi.org/10.1007/s00421-019-04103-y

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