Background
Materials and methods
Study participants
Assessment of the cumulative radiation dose
Assessment of hematological parameters
Statistical analysis
Results
Characteristics of the study population
Variable | No. (n = 1265) | Hemoglobin (g/L) | Red blood cells (1012/L) | White blood cells (109/L) | Platelets (109/L) | F/t1 | F/t2 | F/t3 | F/t4 | P value1 | P value2 | P value3 | P value4 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Gender | − 33.10 | 20.96 | 3.33 | − 6.20 | < 0.001 | < 0.001 | 0.001 | < 0.001 | |||||
Male | 916 (72.41) | 130.91 ± 10.77 | 5.29 ± 0.51 | 6.37 ± 1.57 | 226.23 ± 49.92 | ||||||||
Female | 349 (27.59) | 153.41 ± 10.82 | 4.63 ± 0.48 | 6.04 ± 1.48 | 246.09 ± 53.56 | ||||||||
Age at baseline | − 0.51 | 3.39 | 2.18 | 3.73 | 0.613# | 0.001# | 0.029 | < 0.001 | |||||
< 40 years | 818 (64.66) | 147.05 ± 15.22 | 5.15 ± 0.61 | 6.35 ± 1.56 | 235.69 ± 51.23 | ||||||||
≥ 40 years | 447 (35.34) | 147.48 ± 13.90 | 5.04 ± 0.53 | 6.15 ± 1.52 | 224.41 ± 51.81 | ||||||||
Service at baseline | − 2.11 | 0.18 | − 1.86 | 0.78 | 0.035 | 0.857# | 0.063 | 0.433 | |||||
< 10 years | 787 (62.21) | 146.52 ± 14.95 | 5.11 ± 0.61 | 6.21 ± 1.51 | 232.60 ± 51.20 | ||||||||
≥ 10 years | 478 (37.79) | 148.32 ± 14.38 | 5.11 ± 0.55 | 6.38 ± 1.60 | 230.24 ± 52.53 | ||||||||
Occupation | 65.33 | 26.92 | 2.37 | 6.82 | < 0.001# | < 0.001 | 0.072# | < 0.001# | |||||
Physician | 808 (63.87) | 149.25 ± 13.37 | 5.17 ± 0.55 | 6.23 ± 1.49 | 227.50 ± 51.19 | ||||||||
Radiation technician | 296 (23.40) | 147.19 ± 16.04 | 5.12 ± 0.61 | 6.49 ± 1.67 | 240.15 ± 54.73 | ||||||||
Nurse | 111 (8.77) | 132.78 ± 11.32 | 4.66 ± 0.59 | 6.21 ± 1.66 | 243.15 ± 47.47 | ||||||||
Others | 50 (3.95) | 146.21 ± 17.28 | 5.03 ± 0.55 | 6.05 ± 1.37 | 224.31 ± 40.28 | ||||||||
Medical level | |||||||||||||
Primary | 220 (17.39) | 147.17 ± 14.29 | 5.12 ± 0.61 | 6.25 ± 1.60 | 229.38 ± 50.90 | 0.01 | 0.01 | 0.05 | 1.61 | 0.986 | 0.987 | 0.947 | 0.201 |
Secondary | 406 (32.09) | 147.12 ± 14.60 | 5.11 ± 0.56 | 6.28 ± 1.53 | 228.91 ± 52.37 | ||||||||
Third | 639 (50.51) | 147.27 ± 15.04 | 5.11 ± 0.59 | 6.29 ± 1.55 | 234.28 ± 51.49 | ||||||||
Smoking habits | − 8.35 | − 3.75 | − 4.94 | 1.29 | < 0.001# | < 0.001# | < 0.001# | 0.197 | |||||
No | 941 (74.39) | 145.33 ± 14.82 | 5.08 ± 0.61 | 6.14 ± 1.48 | 232.81 ± 51.87 | ||||||||
Yes | 324 (25.61) | 152.65 ± 13.17 | 5.20 ± 0.49 | 6.66 ± 1.68 | 228.51 ± 51.14 | ||||||||
The cumulative radiation dose (mSv) | 0.09 | 0.81 | 2.38 | 4.68 | 0.407 | 0.444 | 0.094# | 0.010# | |||||
0~2.586 | 148.13 ± 14.53 | 5.14 ± 0.57 | 6.13 ± 1.42 | 225.33 ± 47.35 | |||||||||
2.586~3.757 | 146.97 ± 14.93 | 5.11 ± 0.59 | 6.35 ± 1.64 | 235.75 ± 55.15 | |||||||||
3.758~31.272 | 146.70 ± 14.67 | 5.08 ± 0.59 | 6.28 ± 1.48 | 230.38 ± 48.31 |
Effect of cumulative radiation dose and hematology parameters among medical radiation workers
Correlation between platelets changing and cumulative radiation dose
Variable | β (95% CI) | P | βa(95% CI) | Pa |
---|---|---|---|---|
All | 0.011 (0.006, 0.016) | < 0.001 | 0.008 (0.003, 0.014) | 0.001 |
Gender | ||||
Male | 0.012 (0.006, 0.018) | < 0.001 | 0.013 (0.007, 0.019) | < 0.001 |
Female | − 0.001 (− 0.010, 0.010) | 0.955 | − 0.002 (− 0.012, 0.008) | 0.751 |
Age at baseline | ||||
< 40 years | 0.009 (0.002, 0.015) | 0.007 | 0.004 (− 0.003, 0.010) | 0.262 |
≥ 40 years | 0.023 (0.014,0.032) | < 0.001 | 0.020 (0.010, 0.029) | < 0.001 |
Service at baseline | ||||
< 10 years | 0.027 (0.020, 0.033) | < 0.001 | 0.021 (0.014, 0.027) | < 0.001 |
≥ 10 years | − 0.014 (− 0.023, − 0.006) | 0.001 | − 0.015 (− 0.024, − 0.007) | < 0.001 |
Occupation | ||||
Physician | − 0.002 (− 0.008, 0.004) | 0.530 | − 0.002 (− 0.009, 0.004) | 0.497 |
Radiation technician | 0.047 (0.036, 0.059) | < 0.001 | 0.045 (0.033, 0.056) | < 0.001 |
Nurse | − 0.031 (− 0.048, − 0.015) | < 0.001 | − 0.033 (− 0.049, − 0.016) | < 0.001 |
Others | 0.043 (0.016, 0.069) | 0.002 | 0.037 (0.008, 0.066) | 0.012 |
Medical level | ||||
Primary | 0.006 (− 0.007, 0.020) | 0.336 | 0.015 (0.002, 0.029) | 0.027 |
Secondary | 0.017 (0.007, 0.026) | < 0.001 | 0.019 (0.010, 0.028) | < 0.001 |
Third | 0.010 (0.003, 0.017) | 0.004 | 0.004 (− 0.003, 0.011) | 0.274 |
Smoking habits | ||||
No | 0.007 (0.001, 0.013) | 0.020 | − 0.001 (− 0.007, 0.005) | 0.838 |
Yes | 0.025 (0.015, 0.035) | < 0.001 | 0.037 (0.026, 0.047) | < 0.001 |