nach oben

Molecular Imaging and Biology

Erschienen in:

25.02.2020 | Research Article

Effects of Fever on ¹⁸F-FDG Distribution In Vivo: a Preliminary Study

verfasst von: Yutang Yao, Junjun Cheng, Minggang Su, Xiaohong Ou

Erschienen in: Molecular Imaging and Biology | Ausgabe 4/2020

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Elevated body temperature might change glucose metabolism in human organs. The purpose of this study is to explore ¹⁸F-FDG distribution in febrile patients on the day of ¹⁸F-FDG PET/CT scanning and compare it with patients with a normal temperature.

Procedures

¹⁸F-FDG PET/CT was performed on 69 febrile patients and 82 patients with a normal temperature. Patient sociodemographic data, blood glucose levels before PET/CT, body temperature on the day of the exam, and laboratory test results were collected. Maximal standard uptake values (SUV_max) in the brain, mediastinal blood pool, liver, spleen, and the bone marrow were compared.

Results

Compared with the controls, SUV_max of the febrile patients was significantly lower in the brain, mediastinal blood pool, and the liver (p < 0.01), and higher in the spleen and bone marrow (p < 0.01). In the febrile group, SUV_max was not significantly different between the FDG burden and non-FDG burden patients (p > 0.05). Body temperature was found negatively correlated with SUV_max in the brain (r = − 0.646), mediastinal blood pool (r = − 0.530), and the liver (r = − 0.384), and positively correlated with the SUV_max in the spleen (r = 0.592) and bone marrow (r = 0.651). Multivariate linear regression established body temperature on the day of PET/CT as an independent affecting factor (p < 0.01) for the SUV_max in the brain, mediastinal blood pool, liver, spleen, and bone marrow. The SUV in the brain, liver, and mediastinal blood pool remained different (p < 0.05) after corrected with the SUV_max in the blood pool or liver.

Conclusions

Fever influences ¹⁸F-FDG distribution in multiple human tissues and organs. Altered ¹⁸F-FDG distribution in vivo might affect results of disease lesion detection and tumor therapy response assessment. Correction with blood pool or liver SUV fails to cancel the effects of fever. The day of fever should be avoided for PET/CT scan, especially in assessing tumor therapy response.

von Schulthess GK, Steinert HC, Hany TF (2006) Integrated PET/CT: current applications and future directions. Radiology 238(2):405–422

Blodgett TM, Meltzer CC, Townsend DW (2007) PET/CT: form and function. Radiology 242(2):360–385PubMed

Smith-Bindman R, Miglioretti DL, Johnson E, Lee C, Feigelson HS, Flynn M, Greenlee RT, Kruger RL, Hornbrook MC, Roblin D, Solberg LI, Vanneman N, Weinmann S, Williams AE (2012) Use of diagnostic imaging studies and associated radiation exposure for patients enrolled in large integrated health care systems, 1996-2010. JAMA 307(22):2400–2409PubMed

Hashefi M, Curiel R (2011) Future and upcoming non-neoplastic applications of PET/CT imaging. Ann N Y Acad Sci 1228:167–174PubMed

Wahl RL, Jacene H, Kasamon Y, Lodge MA (2009) From RECIST to PERCIST: evolving considerations for PET response criteria in solid tumors. J Nucl Med 50(Suppl 1):122S–150SPubMedPubMedCentral

Higgins KA, Hoang JK, Roach MC, Chino J, Yoo DS, Turkington TG, Brizel DM (2012) Analysis of pretreatment FDG-PET SUV parameters in head-and-neck cancer: tumor SUVmean has superior prognostic value. Int J Radiat Oncol Biol Phys 82(2):548–553

Na F, Wang J, Li C, Deng L, Xue J, Lu Y (2014) Primary tumor standardized uptake value measured on F18-fluorodeoxyglucose positron emission tomography is of prediction value for survival and local control in non-small-cell lung cancer receiving radiotherapy: meta-analysis. J Thorac Oncol 9(6):834–842PubMedPubMedCentral

Boktor RR, Walker G, Stacey R, Gledhill S, Pitman AG (2013) Reference range for intrapatient variability in blood-pool and liver SUV for 18F-FDG PET. J Nucl Med 54(5):677–682PubMed

Thie JA (2014) Understanding SUV variability in reference tissue for 18F-FDG PET with a simple measurement model. J Nucl Med 55(2):352PubMed

10.

Viglianti BL, Wong KK, Wimer SM, Parameswaran A, Nan B, Ky C, Townsend DM, Rubello D, Frey KA, Gross MD (2017) Effect of hyperglycemia on brain and liver (18)F-FDG standardized uptake value (FDG SUV) measured by quantitative positron emission tomography (PET) imaging. Biomed Pharmacother 88:1038–1045PubMedPubMedCentral

11.

Viglianti BL, Wale DJ, Wong KK, Johnson TD, Ky C, Frey KA, Gross MD (2018) Effects of tumor burden on reference tissue standardized uptake for PET imaging: modification of PERCIST criteria. Radiology:171356

12.

Dong MJ, Lin XT, Zhao J, Guan YH, Zuo CT, Chen X, Dai JZ, Jiang BD (2006) Malignant tumor with false negative 18F-FDG PET image. Zhonghua zhong liu za zhi [Chin J Oncol] 28(9):713–717

13.

Roarke MC, Nguyen BD, Pockaj BA (2008) Desmoplastic melanoma: true positive and false negative findings on F-18 FDG-PET/CT. Clin Nucl Med 33(8):562–564PubMed

14.

Mahmood S, Martinez de Llano SR (2008) Paget disease of the humerus mimicking metastatic disease in a patient with metastatic malignant mesothelioma on whole body F-18 FDG PET/CT. Clin Nucl Med 33(7):510–512PubMed

15.

Acar C, Akkas BE, Sen I, Sozen S, Kitapci MT (2008) False positive 18F-FDG PET scan in adrenal oncocytoma. Urol Int 80(4):444–447PubMed

16.

Kim IJ, Kim SJ, Kim YK (2009) Age- and sex-associated changes in cerebral glucose metabolism in normal healthy subjects: statistical parametric mapping analysis of F-18 fluorodeoxyglucose brain positron emission tomography. Acta Radiol 50(10):1169–1174PubMed

17.

Zhu H, Goris M (2012) Factors affecting brain metabolism measured with 18FDG. Open J Med Imaging 2(1):19–22

18.

Hsieh TC, Lin WY, Ding HJ, Sun SS, Wu YC, Yen KY, Kao CH (2012) Sex- and age-related differences in brain FDG metabolism of healthy adults: an SPM analysis. J Neuroimaging Off J Am Soc Neuroimaging 22(1):21–27

19.

Busing KA, Schonberg SO, Brade J, Wasser K (2013) Impact of blood glucose, diabetes, insulin, and obesity on standardized uptake values in tumors and healthy organs on 18F-FDG PET/CT. Nucl Med Biol 40(2):206–213PubMed

20.

Blatteis CM (2003) Fever: pathological or physiological, injurious or beneficial? J Therm Biol 28(1):1–13

21.

Cannon JG (2013) Perspective on fever: the basic science and conventional medicine. Complement Ther Med 21(Suppl 1):S54–S60PubMed

22.

Shivamurthy VK, Tahari AK, Marcus C, Subramaniam RM (2015) Brain FDG PET and the diagnosis of dementia. AJR Am J Roentgenol 204(1):W76–W85PubMed

23.

Chiba Y, Iseki E, Fujishiro H, Ota K, Kasanuki K, Suzuki M, Hirayasu Y, Arai H, Sato K (2016) Early differential diagnosis between Alzheimer’s disease and dementia with Lewy bodies: comparison between (18)F-FDG PET and (123)I-IMP SPECT. Psychiatry Res 249:105–112

24.

Juweid ME, Stroobants S, Hoekstra OS, Mottaghy FM, Dietlein M, Guermazi A, Wiseman GA, Kostakoglu L, Scheidhauer K, Buck A, Naumann R, Spaepen K, Hicks RJ, Weber WA, Reske SN, Schwaiger M, Schwartz LH, Zijlstra JM, Siegel BA, Cheson BD (2007) Use of positron emission tomography for response assessment of lymphoma: consensus of the Imaging Subcommittee of International Harmonization Project in Lymphoma. J Clin Oncol Off J Am Soc Clin Oncol 25(5):571–578

25.

Cheson BD (2018) PET/CT in lymphoma: current overview and future directions. Semin Nucl Med 48(1):76–81PubMed

26.

Karls S, Shah H, Jacene H (2018) PET/CT for lymphoma post-therapy response assessment in other lymphomas, response assessment for autologous stem cell transplant, and lymphoma follow-up. Semin Nucl Med 48(1):37–49PubMed

27.

Kobe C, Dietlein M, Hellwig D (2018) PET/CT for lymphoma post-therapy response assessment in Hodgkin lymphoma and diffuse large B-cell lymphoma. Semin Nucl Med 48(1):28–36PubMed

28.

Fallanca F, Alongi P, Incerti E, Gianolli L, Picchio M, Bomanji J (2015) Deauville criteria and international harmonization project criteria at the end of 1st line therapy in lymphoma patients: response assessment and prognostic evaluation. J Nucl Med 56(3):1355–1355

29.

Fueger BJ, Czernin J, Hildebrandt I, Tran C, Halpern BS, Stout D, Phelps ME, Weber WA (2006) Impact of animal handling on the results of 18F-FDG PET studies in mice. J Nucl Med 47(6):999–1006PubMed

30.

Wan XH, Lu XF (2013) Diagnostics. In: Common symptoms, 8th edn. People’s Medical Publishing House, Beijing, pp 8–9

31.

Meller J, Altenvoerde G, Munzel U, Jauho A, Behe M, Gratz S, Luig H, Becker W (2000) Fever of unknown origin: prospective comparison of [18F]FDG imaging with a double-head coincidence camera and gallium-67 citrate SPET. Eur J Nucl Med 27(11):1617–1625PubMed

32.

Bleeker-Rovers CP, de Kleijn EM, Corstens FH, van der Meer JW, Oyen WJ (2004) Clinical value of FDG PET in patients with fever of unknown origin and patients suspected of focal infection or inflammation. Eur J Nucl Med Mol Imaging 31(1):29–37PubMed

33.

Besson FL, Chaumet-Riffaud P, Playe M, Noel N, Lambotte O, Goujard C, Prigent A, Durand E (2016) Contribution of (18)F-FDG PET in the diagnostic assessment of fever of unknown origin (FUO): a stratification-based meta-analysis. Eur J Nucl Med Mol Imaging 43(10):1887–1895PubMed

34.

Mrozek S, Vardon F, Geeraerts T (2012) Brain temperature: physiology and pathophysiology after brain injury. Anesthesiol Res Pract 2012:989487PubMedPubMedCentral

35.

Baracos VE, Whitmore WT, Gale R (1987) The metabolic cost of fever. Can J Physiol Pharmacol 65(6):1248–1254PubMed

36.

Stocchetti N, Protti A, Lattuada M, Magnoni S, Longhi L, Ghisoni L, Egidi M, Zanier ER (2005) Impact of pyrexia on neurochemistry and cerebral oxygenation after acute brain injury. J Neurol Neurosurg Psychiatry 76(8):1135–1139

37.

Szablewski L (2013) Expression of glucose transporters in cancers. Biochim Biophys Acta 1835(2):164–169PubMed

38.

Kostakoglu L, Hardoff R, Mirtcheva R, Goldsmith SJ (2004) PET-CT fusion imaging in differentiating physiologic from pathologic FDG uptake. Radiographics 24(5):1411–1431PubMed

39.

Zucker S, Friedman S, Lysik RM (1974) Bone marrow erythropoiesis in the anemia of infection, inflammation, and malignancy. J Clin Invest 53(4):1132–1138PubMedPubMedCentral

40.

Adams HJ, Kwee TC, Fijnheer R, Dubois SV, Nievelstein RA, de Klerk JM (2015) Diffusely increased bone marrow FDG uptake in recently untreated lymphoma: incidence and relevance. Eur J Haematol 95(1):83–89PubMed

41.

Hapkido H, Kartamihardja AS (2016) Differential diagnosis of diffuse bone marrow uptake on 18F-FDG PET/CT. Int J Clin Biomed Res 2(1):1–5

42.

Berthet L, Cochet A, Kanoun S, Berriolo-Riedinger A, Humbert O, Toubeau M, Dygai-Cochet I, Legouge C, Casasnovas O, Brunotte F (2013) In newly diagnosed diffuse large B-cell lymphoma, determination of bone marrow involvement with 18F-FDG PET/CT provides better diagnostic performance and prognostic stratification than does biopsy. J Nucl Med 54(8):1244–1250

43.

Li J, Huang Y, Ji T, Tan R, Chen W (2002) Study on multi-parameter dynamic measurement of the elastic properties of red blood cell membrane based on image analyzing technique. Acta Biophys Sin 18(3):350–354

44.

Mebius RE, Kraal G (2005) Structure and function of the spleen. Nat Rev Immunol 5(8):606–616

45.

Pivkin IV, Peng Z, Karniadakis GE, Buffet PA, Dao M, Suresh S (2016) Biomechanics of red blood cells in human spleen and consequences for physiology and disease. Proc Natl Acad Sci U S A 113(28):7804–7809PubMedPubMedCentral

46.

Ohnhaus EE, Tilvis R (1976) Liver blood flow. Metabolic heat production and body temperature before, during and after phenobarbitone administration. Acta Hepatogastroenterol 23(6):404–408

47.

Kisauzi DN, Leek BF (1991) The effects of experimentally induced fever on the estimated blood flow to and oxygen utilization by the liver and the viscera drained by the portal vein in sheep. Vet Res Commun 15(2):95–105PubMed

48.

Walter EJ, Hanna-Jumma S, Carraretto M, Forni L (2016) The pathophysiological basis and consequences of fever. Crit Care 20(1):200PubMedPubMedCentral

49.

Malladi A, Viner M, Jackson T, Mercier G, Subramaniam RM (2013) PET/CT mediastinal and liver FDG uptake: effects of biological and procedural factors. J Med Imaging Radiat Oncol 57(2):169–175PubMed

50.

Lin CY, Ding HJ, Lin T, Lin CC, Kuo TH, Kao CH (2010) Positive correlation between serum liver enzyme levels and standard uptake values of liver on FDG-PET. Clin Imaging 34(2):109–112PubMed

51.

Liu G, Li Y, Hu P, Cheng D, Shi H (2015) The combined effects of serum lipids, BMI, and fatty liver on 18F-FDG uptake in the liver in a large population from China: an 18F-FDG-PET/CT study. Nucl Med Commun 36(7):709–716PubMed

Titel: Effects of Fever on 18F-FDG Distribution In Vivo: a Preliminary Study
verfasst von: Yutang Yao
Junjun Cheng
Minggang Su
Xiaohong Ou
Publikationsdatum: 25.02.2020
Verlag: Springer International Publishing
Erschienen in: Molecular Imaging and Biology / Ausgabe 4/2020
Print ISSN: 1536-1632
Elektronische ISSN: 1860-2002
DOI: https://doi.org/10.1007/s11307-020-01486-9

Neu im Fachgebiet Radiologie

18.04.2024 | Pädiatrische Notfallmedizin | Nachrichten

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Effects of Fever on ¹⁸F-FDG Distribution In Vivo: a Preliminary Study

Abstract

Purpose

Procedures

Results

Conclusions

Neu im Fachgebiet Radiologie

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

„Nur wer sich gut aufgehoben fühlt, kann auch für Patientensicherheit sorgen“

Wie toxische Männlichkeit der Gesundheit von Männern schadet

Studie bestätigt Potenzial von KI in der Radiologie

Update Radiologie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Purpose

Procedures

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 4/2020

Body Mass Index and Age Effects on Brain 11β-Hydroxysteroid Dehydrogenase Type 1: a Positron Emission Tomography Study

Preclinical Evaluation and Dosimetry of [111In]CHX-DTPA-scFv78-Fc Targeting Endosialin/Tumor Endothelial Marker 1 (TEM1)

Targeting Phosphatidylethanolamine with Fluorine-18 Labeled Small Molecule Probe for Apoptosis Imaging

Assessment of Metastatic and Reactive Sentinel Lymph Nodes with B7-H3-Targeted Ultrasound Molecular Imaging: A Longitudinal Study in Mouse Models

Therapy-Induced Changes in CXCR4 Expression in Tumor Xenografts Can Be Monitored Noninvasively with N-[11C]Methyl-AMD3465 PET

The Acute and Early Effects of Whole-Brain Irradiation on Glial Activation, Brain Metabolism, and Behavior: a Positron Emission Tomography Study

Neu im Fachgebiet Radiologie

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

„Nur wer sich gut aufgehoben fühlt, kann auch für Patientensicherheit sorgen“

Wie toxische Männlichkeit der Gesundheit von Männern schadet

Studie bestätigt Potenzial von KI in der Radiologie

Update Radiologie