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01.06.2009 | Experimental

Effects of frequency and inspiratory plateau pressure during recruitment manoeuvres on lung and distal organs in acute lung injury

verfasst von: Paula W. Steimback, Gisele P. Oliveira, Andréia F. Rzezinski, Pedro L. Silva, Cristiane S. N. B. Garcia, Graziela Rangel, Marcelo M. Morales, José R. Lapa e Silva, Vera L. Capelozzi, Paolo Pelosi, Patricia R. M. Rocco

Erschienen in: Intensive Care Medicine | Ausgabe 6/2009

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Abstract

Purpose

To evaluate the effects of frequency and inspiratory plateau pressure (Pplat) during recruitment manoeuvres (RMs) on lung and distal organs in acute lung injury (ALI).

Methods

We studied paraquat-induced ALI rats. At 24 h, rats were anesthetized and RMs were applied using continuous positive airway pressure (CPAP, 40 cmH₂O/40 s) or three-different sigh strategies: (a) 180 sighs/h and Pplat = 40 cmH₂O (S180/40), (b) 10 sighs/h and Pplat = 40 cmH₂O (S10/40), and (c) 10 sighs/h and Pplat = 20 cmH₂O (S10/20).

Results

S180/40 yielded alveolar hyperinflation and increased lung and kidney epithelial cell apoptosis as well as type III procollagen (PCIII) mRNA expression. S10/40 resulted in a reduction in epithelial cell apoptosis and PCIII expression. Static elastance and alveolar collapse were higher in S10/20 than S10/40.

Conclusions

The reduction in sigh frequency led to a protective effect on lung and distal organs, while the combination with reduced Pplat worsened lung mechanics and histology.

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Titel: Effects of frequency and inspiratory plateau pressure during recruitment manoeuvres on lung and distal organs in acute lung injury
verfasst von: Paula W. Steimback
Gisele P. Oliveira
Andréia F. Rzezinski
Pedro L. Silva
Cristiane S. N. B. Garcia
Graziela Rangel
Marcelo M. Morales
José R. Lapa e Silva
Vera L. Capelozzi
Paolo Pelosi
Patricia R. M. Rocco
Publikationsdatum: 01.06.2009
Verlag: Springer-Verlag
Erschienen in: Intensive Care Medicine / Ausgabe 6/2009
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-009-1439-y

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