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11.11.2017 | Original Article

Effects of Growth Hormone Treatment on Lipid Profiles

verfasst von: Toshihide Kubo, Mahoko Furujo, Kyohei Takahashi, Yuki Hyodo, Hiroki Tsuchiya, Mariko Hattori, Shoko Fujinaga, Kenji Urayama

Erschienen in: Indian Journal of Pediatrics | Ausgabe 4/2018

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Abstract

Objectives

To assess the effects of growth hormone (GH) on lipid profiles in children and whether the effect is pharmacological.

Methods

The authors determined serum levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), and low-density lipoprotein cholesterol (LDL-C) every year during 3-y GH treatment in 48 GH deficient (GHD) short children and 22 children with short stature born small for gestational age (SGA).

Results

The abnormally high levels of TC, non-HDL-C, and LDL-C showed a high frequency in GHD short children compared with epidemiological studies in Japan. The high prevalence of high level of TC was also shown in SGA short children. Three-year GH treatment decreased serum TC, non-HDL-C, and LDL-C levels in both patient groups.

Conclusions

GH treatment is clearly a pharmacological therapy in SGA short children and so may also be in GHD short children at the Japanese standard therapeutic dose. Taken together, GH improves lipid profiles, and its effect has the possibility of medical properties.

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Titel: Effects of Growth Hormone Treatment on Lipid Profiles
verfasst von: Toshihide Kubo
Mahoko Furujo
Kyohei Takahashi
Yuki Hyodo
Hiroki Tsuchiya
Mariko Hattori
Shoko Fujinaga
Kenji Urayama
Publikationsdatum: 11.11.2017
Verlag: Springer India
Erschienen in: Indian Journal of Pediatrics / Ausgabe 4/2018
Print ISSN: 0019-5456
Elektronische ISSN: 0973-7693
DOI: https://doi.org/10.1007/s12098-017-2509-8

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Springer Medizin

Effects of Growth Hormone Treatment on Lipid Profiles

Abstract

Objectives

Methods

Results

Conclusions

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Springer Medizin

Abstract

Objectives

Methods

Results

Conclusions

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