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Archives of Virology

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01.09.2016 | Brief Report

Effects of hemagglutinin amino acid substitutions in H9 influenza A virus escape mutants

verfasst von: Irina A. Rudneva, Tatiana A. Timofeeva, Anna V. Ignatieva, Aleksandr A. Shilov, Natalia A. Ilyushina

Erschienen in: Archives of Virology | Ausgabe 12/2016

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Abstract

We assessed the pH optimum of fusion, HA thermostability, and in vitro replication kinetics of previously obtained influenza H9 escape mutants. The N198S mutation significantly increased the optimum pH of fusion. Four HA changes, S133N, T189A, N198D, and L226Q, were associated with a significant increase in HA thermostability compared to the wild-type virus. HA amino acid changes at positions 116, 133, 135, 157, 162, and 193 significantly decreased the replicative ability of H9 escape mutants in vitro. Monitoring of pleiotropic effects of the HA mutations found in H9 escape mutants is essential for accurate prediction of all possible outcomes of immune selection of H9 influenza A viruses.

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Titel: Effects of hemagglutinin amino acid substitutions in H9 influenza A virus escape mutants
verfasst von: Irina A. Rudneva
Tatiana A. Timofeeva
Anna V. Ignatieva
Aleksandr A. Shilov
Natalia A. Ilyushina
Publikationsdatum: 01.09.2016
Verlag: Springer Vienna
Erschienen in: Archives of Virology / Ausgabe 12/2016
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-016-3038-x

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Effects of hemagglutinin amino acid substitutions in H9 influenza A virus escape mutants

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