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01.12.2017 | Research article | Ausgabe 1/2017 Open Access

BMC Complementary and Alternative Medicine 1/2017

Effects of hyperthermic baths on depression, sleep and heart rate variability in patients with depressive disorder: a randomized clinical pilot trial

Zeitschrift:
BMC Complementary and Alternative Medicine > Ausgabe 1/2017
Autoren:
Johannes Naumann, Julian Grebe, Sonja Kaifel, Tomas Weinert, Catharina Sadaghiani, Roman Huber
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​s12906-017-1676-5) contains supplementary material, which is available to authorized users.

Abstract

Background

Despite advances in the treatment of depression, one-third of depressed patients fail to respond to conventional antidepressant medication. There is a need for more effective treatments with fewer side effects. The primary aim of this study was to determine whether hyperthermic baths reduce depressive symptoms in adults with depressive disorder.

Methods

Randomized, two-arm placebo-controlled, 8-week pilot trial. Medically stable outpatients with confirmed depressive disorder (ICD-10: F32/F33) who were moderately depressed as determined by the 17-item Hamilton Scale for Depression (HAM-D) score ≥18 were randomly assigned to 2 hyperthermic baths (40 °C) per week for 4 weeks or a sham intervention with green light and follow-up after 4 weeks. Main outcome measure was the change in HAM-Dtotal score from baseline (T0) to the 2-week time point (T1).

Results

A total of 36 patients were randomized (hyperthermic baths, n = 17; sham condition, n = 19). The intention-to-treat analysis showed a significant (P = .037) difference in the change in HAM-Dtotal score with 3.14 points after 4 interventions (T1) in favour of the hyperthermic bath group compared to the placebo group.

Conclusions

This pilot study suggests that hyperthermic baths do have generalized efficacy in depressed patients.

Trial registration

DRKS00004803at drks-neu.uniklinik-freiburg.de, German Clinical Trials Register (registration date 2016-02-02), retrospectively registered.
Zusatzmaterial
Additional file 1: Study protocol. (PDF 40 kb)
12906_2017_1676_MOESM1_ESM.pdf
Additional file 2: PP analysis. Table S1. 17-Item Hamilton Scale for Depression: Differences between Baseline and T1 (after 4 Interventions) in the Hyperthermic Bath Group compared to the Placebo Group, N = 30). Table S2. 17-Item Hamilton Scale for Depression: Differences between Baseline and T2 (4 weeks after treatment) in the Hyperthermic Bath Group compared to the Placebo Group, N = 28). Table S3. Summary of Adverse Events. Figure S1. Effects of Hyperthermic Baths (HTB) and Green Light (Placebo) in Depressed Patients. Figure S2. Effects of Hyperthermic Baths (HTB) and Green Light (Placebo) in Depressed Patients. 17-Hamilton Scale for Depression Subscales. (DOCX 114 kb)
12906_2017_1676_MOESM2_ESM.docx
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