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01.03.2018 | Retinal Disorders | Ausgabe 5/2018

Graefe's Archive for Clinical and Experimental Ophthalmology 5/2018

Effects of intravitreal injection of ranibizumab on choroidal structure and blood flow in eyes with diabetic macular edema

Zeitschrift:
Graefe's Archive for Clinical and Experimental Ophthalmology > Ausgabe 5/2018
Autoren:
Masahiro Okamoto, Mariko Yamashita, Nahoko Ogata

Abstract

Purpose

To determine the effects of an intravitreal injection of ranibizumab (IVR) on the choroidal structure and blood flow in eyes with diabetic macular edema (DME).

Methods

Twenty-eight consecutive patients with DME who received an IVR and 20 non-diabetic, age-matched controls were followed for 1 month. The eyes with DME were divided into those with prior panretinal photocoagulation (PRP, n = 16) and those without prior PRP (no-PRP, n = 12). The enhanced depth imaging optical coherence tomography (EDI-OCT) scans and Niblack’s image binarization were performed to determine the choroidal structure. The choroidal blood flow was determined by laser speckle flowgraphy.

Results

The subfoveal choroidal thickness at the baseline was significantly thicker in the no-PRP group than in the PRP-treated group. After IVR, the best-corrected visual acuity (BCVA) and central retinal thickness in eyes with DME were significantly improved compared to the baseline values. There were significant differences in the choroidal thickness, total choroidal area, and choroidal vascularity index between the groups after IVR. Choroidal vascular index and choroidal blood flow were significantly reduced only in the no-PRP group and not in the PRP-treated group. In addition, the correlation between the central retinal thickness and the choroidal blood flow was significant in the no-PRP group (r = 0.47, P < 0.05).

Conclusions

A single IVR will reduce the central retinal thickness and improve the BCVA in eyes with DME in both the no-PRP and PRP-treated group. IVR affected the choroidal vasculature and blood flow significantly, and a significant correlation was found between the central retinal thickness and the choroidal blood flow in eyes without PRP.

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