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Graefe's Archive for Clinical and Experimental Ophthalmology

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01.03.2018 | Retinal Disorders

Effects of intravitreal injection of ranibizumab on choroidal structure and blood flow in eyes with diabetic macular edema

verfasst von: Masahiro Okamoto, Mariko Yamashita, Nahoko Ogata

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 5/2018

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Abstract

Purpose

To determine the effects of an intravitreal injection of ranibizumab (IVR) on the choroidal structure and blood flow in eyes with diabetic macular edema (DME).

Methods

Twenty-eight consecutive patients with DME who received an IVR and 20 non-diabetic, age-matched controls were followed for 1 month. The eyes with DME were divided into those with prior panretinal photocoagulation (PRP, n = 16) and those without prior PRP (no-PRP, n = 12). The enhanced depth imaging optical coherence tomography (EDI-OCT) scans and Niblack’s image binarization were performed to determine the choroidal structure. The choroidal blood flow was determined by laser speckle flowgraphy.

Results

The subfoveal choroidal thickness at the baseline was significantly thicker in the no-PRP group than in the PRP-treated group. After IVR, the best-corrected visual acuity (BCVA) and central retinal thickness in eyes with DME were significantly improved compared to the baseline values. There were significant differences in the choroidal thickness, total choroidal area, and choroidal vascularity index between the groups after IVR. Choroidal vascular index and choroidal blood flow were significantly reduced only in the no-PRP group and not in the PRP-treated group. In addition, the correlation between the central retinal thickness and the choroidal blood flow was significant in the no-PRP group (r = 0.47, P < 0.05).

Conclusions

A single IVR will reduce the central retinal thickness and improve the BCVA in eyes with DME in both the no-PRP and PRP-treated group. IVR affected the choroidal vasculature and blood flow significantly, and a significant correlation was found between the central retinal thickness and the choroidal blood flow in eyes without PRP.

Romero-Aroca P (2011) Managing diabetic macular edema: the leading cause of diabetes blindness. World J Diabetes 2:98–104CrossRefPubMedPubMedCentral

Cao J, McLeod S, Merges CA, Lutty GA (1998) Choriocapillaris degeneration and related pathologic changes in human diabetic eyes. Arch Ophthalmol 116:589–597CrossRefPubMed

Querques G, Lattanzio R, Querques L et al (2012) Enhanced depth imaging optical coherence tomography in type 2 diabetes. Invest Ophthalmol Vis Sci 53:6017–6024CrossRefPubMed

Esmaeelpour M, Považay B, Hermann B et al (2011) Mapping choroidal and retinal thickness variation in type 2 diabetes using three-dimensional 1060-nm optical coherence tomography. Invest Ophthalmol Vis Sci 52:5311–5316CrossRefPubMed

Vujosevic S, Martini F, Cavarzeran F, Pilotto E, Midena E (2012) Macular and peripapillary choroidal thickness in diabetic patients. Retina 32:1781–1790CrossRefPubMed

Regatieri CV, Branchini L, Carmody J, Fujimoto JG, Duker JS (2012) Choroidal thickness in patients with diabetic retinopathy analyzed by spectral-domain optical coherence tomography. Retina 32:563–568CrossRefPubMedPubMedCentral

Brown DM, Nguyen QD, Marcus DM et al (2013) Long-term outcomes of ranibizumab therapy for diabetic macular edema: the 36-month results from two phase III trials: RISE and RIDE. Ophthalmology 120:2013–2022CrossRefPubMed

Totan Y, Akyüz TK, Güler E, Güragaç FB (2016) Evaluation of ocular pulse amplitude and choroidal thickness in diabetic macular edema. Eye 30:369–374CrossRefPubMed

Sonoda S, Sakamoto T, Yamashita T et al (2014) Effect of intravitreal triamcinolone acetonide or bevacizumab on choroidal thickness in eyes with diabetic macular edema. Invest Ophthalmol Vis Sci 55:3979–3985CrossRefPubMed

10.

Gerendas BS, Waldstein SM, Simader C et al (2014) Three-dimensional automated choroidal volume assessment on standard spectral-domain optical coherence tomography and correlation with the level of diabetic macular edema. Am J Ophthalmol 158:1039–1048CrossRefPubMedPubMedCentral

11.

Sonoda S, Sakamoto T, Yamashita T et al (2014) Choroidal structure in normal eyes and after photodynamic therapy determined by binarization of optical coherence tomographic images. Invest Ophthalmol Vis Sci 55:3893–3899CrossRefPubMed

12.

Sonoda S, Sakamoto T, Yamashita T et al (2015) Luminal and stromal areas of choroid determined by binarization method of optical coherence tomographic images. Am J Ophthalmol 159:1123–1131CrossRefPubMed

13.

Wilkinson CP, Ferris FL 3rd, Klein RE, Global diabetic retinopathy project group et al (2003) Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales. Ophthalmogy 110:1677–1682CrossRef

14.

Bressler NM, Beck RW, Ferris FL (2011) Panretinal photocoagulation for proliferative diabetic retinopathy. N Engl J Med 365:1520–1526CrossRefPubMed

15.

Geyer O, Neudorfer M, Snir T et al (1999) Pulsatile ocular blood flow in diabetic retinopathy. Acta Ophthalmol Scand 77:522–525CrossRefPubMed

16.

Okamoto M, Matsuura T, Ogata N (2016) Effects of panretinal photocoagulation on choroidal thickness and choroidal blood flow in patients with severe non-proliferative diabetic retinopathy. Retina 36:805–811CrossRefPubMed

17.

Spaide RF, Koizumi H, Pozzoni MC (2008) Enhanced depth imaging spectral-domain optical coherence tomography. Am J Ophthalmol 146:496–500CrossRefPubMed

18.

Brown JS, Flitcroft DI, Ying G et al (2009) In vivo human choroidal thickness measurements: evidence for diurnal fluctuations. Invest Ophthalmol Vis Sci 50:5–12CrossRefPubMed

19.

Tan CS, Ouyang Y, Ruiz H, Sadda SR (2012) Diurnal variation of choroidal thickness in normal, healthy subjects measured by spectral domain optical coherence tomography. Invest Ophthalmol Vis Sci 53:261–266CrossRefPubMed

20.

Sugiyama T, Araie M, Riva CE et al (2010) Use of laser speckle flowgraphy in ocular blood flow research. Acta Ophthalmol 88:723–729CrossRefPubMed

21.

Saito M, Saito W, Hashimoto Y et al (2013) Macular choroidal blood flow velocity decreases with regression of acute central serous chorioretinopathy. Br J Ophthalmol 97:775–780CrossRefPubMed

22.

Kim JT, Lee DH, Joe SG, Kim JG, Yoon YH (2013) Changes in choroidal thickness in relation to the severity of retinopathy and macular edema in type 2 diabetic patients. Invest Ophthalmol Vis Sci 54:3378–3384CrossRefPubMed

23.

Adhi M, Brewer E, Waheed NK, Duker JS (2013) Analysis of morphological features and vascular layers of choroid in diabetic retinopathy using spectral-domain optical coherence tomography. JAMA Ophthalmol 131:1267–1274CrossRefPubMedPubMedCentral

24.

Laíns I, Figueira J, Santos AR et al (2014) Choroidal thickness in diabetic retinopathy: the influence of antiangiogenic therapy. Retina 34:1199–1207CrossRefPubMed

25.

Yiu G, Manjunath V, Chiu SJ, Farsiu S, Mahmoud TH (2014) Effect of antivascular endothelial growth factor therapy on choroidal thickness in diabetic macular edema. Am J Ophthalmol 158:745–751CrossRefPubMedPubMedCentral

26.

Rayess N, Rahimy E, Ying GS et al (2015) Baseline choroidal thickness as a predictor for response to anti-vascular endothelial growth factor therapy in diabetic macular edema. Am J Ophthalmol 59:85–91 e1-3CrossRef

27.

Nitta F, Kunikata H, Aizawa N et al (2014) The effect of intravitreal bevacizumab on ocular blood flow in diabetic retinopathy and branch retinal vein occlusion as measured by laser speckle flowgraphy. Clin Ophthalmol 8:1119–1127PubMedPubMedCentral

28.

Örnek N, Inal M, Erbahceci IE, Oğurel T, Örnek K (2015) Effect of intravitreal bevacizumab on retrobulbar blood flow of patients with diabetic macular edema. Eur J Ophthalmol 25:539–545CrossRefPubMed

29.

Mendivil A (1997) Ocular blood flow velocities in patients with proliferative diabetic retinopathy after panretinal photocoagulation. Surv Ophthalmol 42:S89–S95CrossRefPubMed

30.

Esmaeelpour M, Brunner S, Ansari-Shahrezaei S et al (2012) Choroidal thinning in diabetes type 1 detected by 3-dimensional 1060 nm optical coherence tomography. Invest Ophthalmol Vis Sci 53:6803–6809CrossRefPubMed

31.

Ogata N, Ando A, Uyama M, Matsumura M (2001) Expression of cytokines and transcription factors in photocoagulated human retinal pigment epithelial cells. Graefes Arch Clin Exp Ophthalmol 239:87–95CrossRefPubMed

32.

Ogata N, Nishikawa M, Nishimura T, Mitsuma Y, Matsumura M (2002) Unbalanced vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor in diabetic retinopathy. Am J Ophthalmol 134:348–353CrossRefPubMed

33.

Gaudreault J, Fei D, Beyer JC et al (2007) Pharmacokinetics and retinal distribution of ranibizumab, a humanized antibody fragment directed against VEGF-A, following intravitreal administration in rabbits. Retina 27:1260–1266CrossRefPubMed

Titel: Effects of intravitreal injection of ranibizumab on choroidal structure and blood flow in eyes with diabetic macular edema
verfasst von: Masahiro Okamoto
Mariko Yamashita
Nahoko Ogata
Publikationsdatum: 01.03.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 5/2018
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-018-3939-3

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Effects of intravitreal injection of ranibizumab on choroidal structure and blood flow in eyes with diabetic macular edema

Abstract

Purpose

Methods

Results

Conclusions

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Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

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