Skip to main content

26.08.2018 | Original Article | Ausgabe 1/2019

Comparative Clinical Pathology 1/2019

Effects of lead (Pb) exposure on some blood biochemical indices in Cyprinus carpio: potential alleviative effects of thiamine

Comparative Clinical Pathology > Ausgabe 1/2019
Kimiya Nourian, Davar Shahsavani, Hasan Baghshani


The aim of the present work was to study the alleviative properties of thiamine-supplemented fish diet on serum levels of Pb and some biochemical alterations provoked by Pb intoxication in carp. Fish in group 1 formed the untreated control group while fish in groups 2 and 3 received lead acetate (5 ppm) for 15 days. Group 3 was administered with thiamine (50 mg/kg diet) during lead exposure. The results revealed significantly raised levels of circulating Pb and malondialdehyde in group 2 compared to the control group. Significant decreases in circulating Pb and malondialdehyde contents in group 3 were observed following thiamine administration, as compared to group 2. Plasma values of alanine aminotransferase (ALT), urea, creatinine, and uric acid increased in group 2 compared to the control group, although the increase was only significant (p < 0.05) for ALT and creatinine. Thiamine supplementation effectively decreased ALT and creatinine concentrations to the levels observed in the apparently healthy controls. The other plasma biochemical indices quantified did not exhibit any significant modifications among experimental groups. These results are indicative of some variations caused by Pb intoxication in some plasma indices which signify the toxicity of Pb in Cyprinus carpio. Moreover, co-administration of thiamine with Pb notably reversed the expression of circulating biochemical biomarkers provoked by lead poisoning.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

e.Med Interdisziplinär

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf

Über diesen Artikel

Weitere Artikel der Ausgabe 1/2019

Comparative Clinical Pathology 1/2019 Zur Ausgabe



Neu im Fachgebiet Pathologie

15.06.2020 | Pemphigoiderkrankungen | Schwerpunkt: Diagnose entzündlicher Dermatosen | Ausgabe 4/2020

Moderne Diagnostik bullöser Autoimmundermatosen

04.06.2020 | Alopezie | Schwerpunkt: Diagnose entzündlicher Dermatosen | Ausgabe 4/2020

Alopezien – kühlen Kopf bewahren!