Exhaustive exercise causes muscle damage accompanied by oxidative stress and inflammation leading to muscle fatigue and muscle soreness. Lemon verbena leaves, commonly used as tea and refreshing beverage, demonstrated antioxidant and anti-inflammatory properties. The aim of this study was to investigate the effects of a proprietary lemon verbena extract (Recoverben®) on muscle strength and recovery after exhaustive exercise in comparison to a placebo product.
The study was performed as a randomized, placebo-controlled, double-blind study with parallel design. Forty-four healthy males and females, which were 22–50 years old and active in sports, were randomized to 400 mg lemon verbena extract once daily or placebo. The 15 days intervention was divided into 10 days supplementation prior to the exhaustive exercise day (intensive jump-protocol), one day during the test and four days after. Muscle strength (MVC), muscle damage (CK), oxidative stress (GPx), inflammation (IL6) and volunteer-reported muscle soreness intensity were assessed pre and post exercise.
Participants in the lemon verbena group benefited from less muscle damage as well as faster and full recovery. Compared to placebo, lemon verbena extract receiving participants had significantly less exercise-related loss of muscle strength (p = 0.0311) over all timepoints, improved glutathione peroxidase activity by trend (p = 0.0681) and less movement induced pain (p = 0.0788) by trend. Creatine kinase and IL-6 didn’t show significant discrimmination between groups.
Lemon verbena extract (Recoverben®) has been shown to be a safe and well-tolerated natural sports ingredient, by reducing muscle damage after exhaustive exercise.
The trial was registered in the clinical trials registry (clinical trial.gov NCT02923102). Registered 28 September 2016
Paulsen G, Mikkelsen UR, Raastad T, Peake JM. Leucocytes, cytokines and satellite cells: what role do they play in muscle damage and regeneration following eccentric exercise? Exerc Immunol Rev. 2012;18:42-97.
McFarlin BK, Venable AS, Henning AL, Sampson JN, Pennel K, Vingren JL, et al. Reduced inflammatory and muscle damage biomarkers following oral supplementation with bioavailable curcumin. BBA Clin. 2016;5:72–8. https://doi.org/10.1016/j.bbacli.2016.02.003. eCollection@2016 Jun.: 72-78 CrossRefPubMedPubMedCentral
Lewis EJ, Radonic PW, Wolever TM, Wells GD. 21 days of mammalian omega-3 fatty acid supplementation improves aspects of neuromuscular function and performance in male athletes compared to olive oil placebo. J Int Soc Sports Nutr. 2015;12:28. https://doi.org/10.1186/s12970-015-0089-4. eCollection@2015.: 28–0089 CrossRefPubMedPubMedCentral
Quirantes-Pine R, Funes L, Micol V, Segura-Carretero A, Fernandez-Gutierrez A. High-performance liquid chromatography with diode array detection coupled to electrospray time-of-flight and ion-trap tandem mass spectrometry to identify phenolic compounds from a lemon verbena extract. J Chromatogr A. 2009;1216:5391–7. CrossRefPubMed
Choupani M, Arabshahi S, Alami M. Antioxidant properties of various solvent extracts of lemon verbena (Lippia Citriodora) leaves. Int J Adv Biol Biomed Res. 2014;2
Mauriz E, Vallejo D, Tunon MJ, Rodriguez-Lopez JM, Rodriguez-Perez R, Sanz-Gomez J, et al. Effects of dietary supplementation with lemon verbena extracts on serum inflammatory markers of multiple sclerosis patients. Nutr Hosp. 2014;31:764–71. PubMed
Justia Trademarks. Recoverben - Trademark Details. 2017. ( https://trademarks.justia.com/872/20/recoverben-87220306.html).
Buchwald-Werner S, Naka I, Dressler D, Reule C, Schoen C. Aloysia Citriodora extract targeting sports nutrition. In vitro study on anti-inflammatory effects by cyclooxygenases inhibition. Agro Food ind Hi Tech. 2017;28:42–4.
Ahmed M, Qadir MA, Hameed A, Imran M, Muddassar M. Screening of curcumin-derived isoxazole, pyrazoles, and pyrimidines for their anti-inflammatory, antinociceptive, and cyclooxygenase-2 inhibition. Chem Biol Drug Des. 2018;91:338–43.
IPAQ Group. International physical activity questionnaire. 2016. Ref Type: Internet Communication.
Hug B. Validierung und Weiterentwicklung eines Kurzfragebogens zur Beurteilung des Ernährungsmusters. Institut für Biologische Chemie und Ernährungswissenschaft Prof Dr med H K Biesalski: Diplomarbeit; 2006.
Novel Food catalogue Lippia triphylla. 2017. http://ec.europa.eu/food/safety/novel_food/catalogue/search/public/index.cfm##.
Commission regulation (EC) No 1881/2006. 2017. http://eur-lex.europa.eu/legal-content/EN/TXT/PDF/?uri=CELEX:02006R1881-20150731&from=EN.
Howatson G, Hoad M, Goodall S, Tallent J, Bell PG, French DN. Exercise-induced muscle damage is reduced in resistance-trained males by branched chain amino acids: a randomized, double-blind, placebo controlled study. J Int Soc Sports Nutr. 2012;9:20.
Borg GA. Psychophysical bases of perceived exertion. Med Sci Sports Exerc. 1982;14:377–81. PubMed
Marzin T, Lorkowski G, Reule C, Rau S, Pabst E, Vester JC. Effects of a systemic enzyme therapy in healthy active adults after exhaustive eccentric exercise: a randomised, two-stage, double-blinded, placebo-controlled trial. BMJ Open Sport Exerc Med. 2017;2:e000191.
Stolle D, Rick W. An improved method for the determination of Creatine kinase activity in serum. J Clin Chem Clin Biochem. 1976;14:239–44. PubMed
Reihmane D, Dela F. Interleukin-6: possible biological roles during exercise. Eur J Sport Sci. 2014;14:242-50.
Steinbacher P, Eckl P. Impact of oxidative stress on exercising skeletal muscle. Biomol Ther. 2015;5:356–77.
Peake JM, Neubauer O, Della Gatta PA, Nosaka K. Muscle damage and inflammation during recovery from exercise. J Appl Physiol (1985). 2017;122:559–70. CrossRef
Wankhede S, Langade D, Joshi K, Sinha SR, Bhattacharyya S. Examining the effect of Withania Somnifera supplementation on muscle strength and recovery: a randomized controlled trial. J Int Soc Sports Nutr. 2015;12:43. https://doi.org/10.1186/s12970-015-0104-9. eCollection@2015.: 43-0104 CrossRefPubMedPubMedCentral
Drobnic F, Riera J, Appendino G, Togni S, Franceschi F, Valle X, et al. Reduction of delayed onset muscle soreness by a novel curcumin delivery system (Meriva(R)): a randomised, placebo-controlled trial. J Int Soc Sports Nutr. 2014;11:31. https://doi.org/10.1186/1550-2783-11-31. eCollection@2014.: 31-11. CrossRefPubMedPubMedCentral
- Effects of lemon verbena extract (Recoverben®) supplementation on muscle strength and recovery after exhaustive exercise: a randomized, placebo-controlled trial
- BioMed Central
Journal of the International Society of Sports Nutrition
Elektronische ISSN: 1550-2783
Neu im Fachgebiet Orthopädie und Unfallchirurgie
Mail Icon II