Background
Methods
Subjects
Survey of lifestyle
Selection of SNPs
SNP genotyping
Statistical analysis
Results
Variables | Case (n = 472) | Control (n = 464) | ORa(95% CIs) | |||
---|---|---|---|---|---|---|
n (%) | n (%) | |||||
Age (year) (mean ± SD) | 54.72 ± 12.45 | 53.56 ± 11.00 | ||||
Menopausal status | ||||||
Pre | 280 | (59) | 271 | (58) | ||
Post | 192 | (41) | 193 | (42) | ||
Height (cm) | ||||||
≤150 | 95 | (20) | 78 | (17) | 1.16 | (0.78-1.71) |
151-155 | 147 | (32) | 145 | (32) | Ref. | |
156-160 | 152 | (33) | 156 | (34) | 0.99 | (0.72-1.36) |
>160 | 72 | (15) | 81 | (18) | 0.93 |
(0.63-1.38)
|
Weight (Kg) | ||||||
≤50 | 159 | (34) | 173 | (37) | 0.97 | (0.69-1.36) |
51-55 | 112 | (24) | 118 | (26) | Ref. | |
56 -60 | 92 | (20) | 78 | (17) | 1.24 | (0.83-1.85) |
>60 | 104 | (22) | 93 | (20) | 1.18 |
(0.80-1.73)
|
BMI (Kg/m2) | ||||||
20 | 102 | (22) | 96 | (21) | 1.39 | (0.96-2.01) |
20-21.9 | 118 | (25) | 150 | (33) | Ref. | |
22-23.9 | 104 | (22) | 102 | (22) | 1.28 | (0.89-1.84) |
≥24 | 139 | (30) | 112 | (24) |
1.54
|
(1.08-2.19)
|
Smoking status | ||||||
Never | 406 | (87) | 432 | (94) | Ref. | |
Current or former | 60 | (13) | 28 | (6) |
2.49
|
(1.56-4.06)
|
Alcohol drinking | ||||||
Never | 240 | (51) | 218 | (47) | ref. | |
Current or former | 231 | (49) | 243 | (53) | 0.91 | (0.70-1.18) |
Alcohol intake (g/day) | ||||||
0 | 240 | (51) | 218 | (48) | ref. | |
<5 | 140 | (30) | 130 | (29) | 1.02 | (0.75-1.39) |
5-10 | 53 | (11) | 62 | (14) | 0.82 | (0.54-1.24) |
10> | 36 | (8) | 45 | (10) | 0.75 | (0.46-1.21) |
Meat intake (times/week) | ||||||
≤1 | 101 | (22) | 66 | (14) | Ref. | |
2-4 | 297 | (64) | 307 | (67) |
0.65
|
(0.45-0.92)
|
≥5 | 67 | (14) | 88 | (19) |
0.51
|
(0.32-0.80)
|
Soy intake (times/week) | ||||||
≤1 | 45 | (10) | 49 | (11) | Ref. | |
2-4 | 236 | (50) | 227 | (50) | 1.12 | (0.72-1.76) |
≥5 | 188 | (40) | 182 | (40) | 1.09 | (0.69-1.72) |
Fish intake (times/week) | ||||||
≤1 | 103 | (22) | 94 | (20) | Ref. | |
2-4 | 297 | (64) | 314 | (68) | 0.85 | (0.62-1.18) |
≥5 | 67 | (14) | 53 | (11) | 1.09 | (0.68-1.74) |
Eggs intake (times/week) | ||||||
≤1 | 108 | (23) | 95 | (21) | Ref. | |
2-4 | 238 | (51) | 247 | (54) | 0.86 | (0.62-1.20) |
≥5 | 120 | (26) | 112 | (25) | 0.96 | (0.66-1.41) |
Milk intake (times/week) | ||||||
≤1 | 84 | (18) | 82 | (18) | Ref. | |
2-4 | 157 | (34) | 135 | (30) | 1.14 | (0.78-1.67) |
≥5 | 226 | (48) | 238 | (52) | 0.92 | (0.64-1.31) |
Fruit intake (times/week) | ||||||
≤1 | 112 | (24) | 112 | (24) | Ref. | |
2-4 | 172 | (37) | 149 | (32) | 1.11 | (0.79-1.57) |
≥5 | 184 | (39) | 199 | (43) | 0.86 | (0.61-1.21) |
Mushrooms intake (times/week) | ||||||
≤1 | 156 | (34) | 120 | (26) | Ref. | |
2-4 | 247 | (53) | 261 | (57) |
0.73
|
(0.54-0.98)
|
≥5 | 61 | (13) | 77 | (17) |
0.60
|
(0.40-0.91)
|
Green and yellow vegetables intake (times/week) | ||||||
≤1 | 47 | (10) | 28 | (6) | Ref. | |
2-4 | 231 | (50) | 204 | (46) | 0.66 | (0.39-1.09) |
≥5 | 183 | (40) | 212 | (48) | 0.48 | (0.29-0.80) |
Coffee intake (times/week) | ||||||
<1 | 132 | (28) | 103 | (22) | Ref. | |
1 | 154 | (33) | 158 | (34) | 0.77 | (0.55-1.09) |
2-3 | 135 | (29 | 160 | (35) |
0.68
|
(0.48-0.96)
|
≥4 | 45 | (10) | 40 | (9) | 0.91 | (0.55-1.51) |
Green tea intake (times/week) | ||||||
<1 | 200 | (43) | 182 | (40) | Ref. | |
1 | 151 | (33) | 133 | (29) | 0.97 | (0.71-1.33) |
2-3 | 63 | (14) | 87 | (19) |
0.63
|
(0.43-0.93)
|
≥4 | 48 | (10) | 55 | (12) | 0.72 | (0.46-1.12) |
Leisure-time exercise | ||||||
None | 254 | (54) | 214 | (46) | Ref. | |
Current | 214 | (46) | 248 | (54) |
0.70
|
(0.54-0.91)
|
Intensity of physical activityb (METs/week) | ||||||
0 | 254 | (56) | 214 | (47) | Ref. | |
>6.0 | 51 | (11) | 42 | (9) | 1.05 | (0.67-1.65) |
6.0-11.9 | 44 | (10) | 60 | (13) |
0.61
|
(0.39-0.93)
|
12.0-23.9 | 48 | (11) | 80 | (17) |
0.51
|
(0.34-0.75)
|
≥24.0 | 52 | (12) | 61 | (13) | 0.70 | (0.46-1.07) |
Age at menarche (year) | ||||||
≤12 | 140 | (30) | 201 | (44) | 0.88 | (0.616-1.25) |
13 | 109 | (23) | 113 | (25) | Ref. | |
≤14 | 217 | (47) | 144 | (31) | 1.25 | (0.882-1.78) |
Parity | ||||||
0 | 86 | (20) | 75 | (17) | Ref. | |
1-2 | 247 | (57) | 265 | (59) | 0.74 | (0.511‒1.06) |
≥3 | 102 | (23) | 107 | (24) | 0.76 | (0.495‒1.15) |
Age at first childbirth (year) | ||||||
<25 | 151 | (40) | 142 | (37) | 1.22 | (0.89-1.68) |
25-29 | 162 | (43) | 187 | (49) | Ref. | |
≥30 | 63 | (17) | 50 | (13) | 1.46 | (0.96-2.25) |
Breastfeeding | ||||||
No | 125 | (27) | 104 | (23) | Ref. | |
Yes | 339 | (73) | 355 | (77) | 0.77 | (0.57-1.04) |
History of benign breast disease | ||||||
No | 351 | (79) | 354 | (79) | Ref. | |
Yes | 93 | (21) | 92 | (21) | 1.03 | (0.74-1.42) |
Family history of breast cancer | ||||||
No | 391 | (88) | 373 | (88) | Ref. | |
Yes | 53 | (12) | 52 | (12) | 0.98 | (0.65-1.47) |
History of HRT use | ||||||
No | 424 | (92) | 412 | (90) | Ref. | |
Yes | 35 | (8) | 45 | (10) | 0.76 | (0.47-1.21) |
Education | ||||||
High school or less | 259 | (55) | 196 | (43) | Ref. | |
Two-year college | 144 | (31) | 144 | (31) | 0.78 | (0.57-1.05) |
University | 64 | (14) | 120 | (26) |
0.41
|
(0.29-0.59)
|
All women (n = 936) | Premenopausal (n = 385) | Postmenopausal (n = 551) | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SNP | No. of | Adjusted ORb
| Multivariate ORc
| No. of | Adjusted ORb
| Multivariate ORc
| No. of | Adjusted ORb
| Multivariate ORc
| |||||||
Gene/location | Genotypea
| Case/Control | OR (95% CI) | OR (95% CI) | Case/Control | OR (95% CI) | OR (95% CI) | Case/Control | OR (95% CI) | OR (95% CI) | ||||||
rs1562430 | CC | 7/4 | Ref. | Ref. | 2/3 | Ref. | Ref. | Ref. | Ref. | |||||||
/8q24 | TC | 96/102 | 0.54 | (0.14-1.85) | 0.62 | (0.15‒2.32) | 33/42 | 1.24 | (0.19-9.85) | 1.10 | (0.15-10.05) | 5/1 | 0.24 | (0.01-1.54) | 0.35 | (0.02-2.80) |
TT | 369/351 | 0.61 | (0.16-2.05) | 0.67 | (0.16‒2.45) | 155/146 | 1.64 | (0.27-12.63) | 1.72 | (0.24-15.14) | 63/60 | 0.24 | (0.01-1.52) | 0.29 | (0.01-2.25) | |
Per allele | 1.05 | (0.79-1.39) | 1.02 | (0.75‒1.39) | 1.08 | (0.81-1.45) | 1.62 | (1.08-2.44) | 214/205 | 1.07 | (0.85-1.36) | 0.80 | (0.56-1.14) | |||
rs889132 | AA | 76/91 | Ref. | Ref. | 34/36 | Ref. | Ref. | Ref. | Ref. | |||||||
MAP3K1/5q | CA | 227/211 | 1.27 | (0.89-1.83) | 1.27 | (0.86‒1.88) | 91/95 | 0.96 | (0.55-1.65) | 0.82 | (0.45-1.50) | 42/55 | 1.59 | (0.98-2.58) | 1.57 | (0.91-2.76) |
CC | 164/160 | 1.21 | (0.83-1.76) | 1.21 | (0.81‒1.81) | 64/61 | 1.07 | (0.60-1.92) | 0.98 | (0.52-1.84) | 136/116 | 1.35 | (0.82-2.23) | 1.30 | (0.74-2.30) | |
Per allele | 1.07 | (0.89-1.29) | 1.07 | (0.88‒1.31) | 1.08 | (0.81-1.45) | 1.11 | (0.83-1.49) | 100/99 | 1.07 | (0.85-1.36) | 1.05 | (0.81-1.36) | |||
rs13283615 | AA | 75/75 | Ref. | Ref. | 29/31 | Ref. | Ref. | ref. | ref. | |||||||
/8q24 | GA | 211/206 | 1.04 | (0.71-1.51) | 1.09 | (0.73‒1.65) | 73/80 | 0.97 | (0.53-1.76) | 1.13 | (0.60-2.17) | 46/44 | 1.10 | (0.68-1.79) | 1.17 | (0.67-2.05) |
GG | 180/177 | 1.03 | (0.70-1.51) | 1.02 | (0.67‒1.55) | 86/78 | 1.14 | (0.63-2.05) | 1.18 | (0.62-2.24) | 138/126 | 0.97 | (0.58-1.61) | 1.09 | (0.61-1.97) | |
Per allele | 1.01 | (0.84-1.21) | 1.00 | (0.81‒1.22) | 1.11 | (0.84-1.47) | 1.03 | (1.00-1.05) | 94/99 | 0.95 | (0.74-1.21) | 0.99 | (0.76-1.28) | |||
rs981782 | TT | 166/149 | Ref. | Ref. | 67/64 | Ref. | Ref. | Ref. | Ref. | |||||||
HCN1/5p12 | TG | 220/234 | 0.85 | (0.64-1.14) | 0.82 | (0.60‒1.13) | 88/98 | 0.85 | (0.54-1.33) | 0.78 | (0.48-1.26) | 99/85 | 0.87 | (0.59-1.27) | 0.83 | (0.54-1.29) |
GG | 82/76 | 0.96 | (0.66-1.41) | 0.88 | (0.58‒1.34) | 31/28 | 1.03 | (0.56-1.91) | 0.97 | (0.50-1.90) | 132/136 | 0.93 | (0.57-1.52) | 0.76 | (0.43-1.34) | |
Per allele | 0.95 | (0.79-1.14) | 0.97 | (0.80‒1.17) | 1.00 | (0.75-1.35) | 1.01 | (0.74-1.38) | 51/48 | 0.93 | (0.73-1.18) | 0.86 | (0.66-1.13) | |||
rs3803662 | CC | 74/91 | Ref. | Ref. | 24/42 | Ref. | Ref. | Ref. | Ref. | |||||||
TNRC9/16q12 | TC | 230/227 | 1.25 | (0.88-1.79) | 1.32 | (0.89‒1.96) | 89/96 | 1.59 | (0.90-2.85) | 1.50 | (0.81-2.80) | 50/49 | 1.08 | (0.68-1.72) | 1.25 | (0.73-2.16) |
TT | 160/142 | 1.41 | (0.97-2.08) |
1.61
|
(1.06‒2.45)
| 72/53 |
2.29
|
(1.25-4.26)
|
2.29
|
(1.20-4.46)
| 141/131 | 1.04 | (0.63-1.71) | 1.27 | (0.72-2.24) | |
Per allele | 1.18 | (0.98-1.42) |
1.28
|
(1.07‒1.55)
|
1.54
|
(1.15-2.09)
|
1.58
|
(1.17-2.16)
| 88/89 | 1.00 | (0.78-1.28) | 1.07 | (0.83-1.39) | |||
rs381798 | TT | 339/347 | Ref. | Ref. | 138/140 | Ref. | Ref. | Ref. | Ref. | |||||||
LSP1/11p15.5 | CT | 120/107 | 1.14 | (0.85-1.55) | 1.07 | (0.77‒1.49) | 46/49 | 0.92 | (0.58-1.48) | 1.00 | (0.60-1.68) | 201/207 | 1.30 | (0.87-1.94) | 1.18 | (0.75-1.86) |
CC | 10/5 | 2.04 | (0.72-6.60) | 1.63 | (0.52‒5.66) | 4/1 | 3.98 | (0.58-78.39) | 3.29 | (0.42-68.89) | 74/58 | 1.65 | (0.46-6.55) | 1.39 | (0.32-6.31) | |
Per allele | 1.19 | (0.91-1.56) | 1.11 | (0.83‒1.49) | 1.07 | (0.70-1.64) | 1.21 | (0.77-1.90) | 6/4 | 1.27 | (0.90-1.81) | 1.14 | (0.78-1.66) | |||
rs2046210 | GG | 213/244 | Ref. | Ref. | 83/107 | Ref. | Ref. | Ref. | Ref. | |||||||
ESR1/6q25.1 | AG | 194/185 | 1.21 | (0.92-1.59) | 1.22 | (0.90‒1.64) | 78/72 | 1.41 | (0.92-2.17) | 1.63 | (1.03-2.61) | 130/137 | 1.11 | (0.78-1.59) | 0.99 | (0.67-1.48) |
AA | 61/34 |
2.03
|
(1.29-3.25)
|
2.16
|
(1.32‒3.59)
| 27/14 |
2.46
|
(1.23-5.10)
|
2.93
|
(1.40-6.40)
| 116/113 | 1.69 | (0.93-3.14) | 1.69 |
(0.84-3.50)
| |
Per allele |
1.34
|
(1.10-1.63)
|
1.37
|
(1.11‒1.70)
|
1.49
|
(1.10-2.03)
|
1.70
|
(1.24-2.35)
| 34/20 | 1.23 | (0.95-1.59) | 1.14 |
(0.86-1.51)
| |||
rs909116 | CC | 166/178 | Ref. | Ref. | 71/64 | Ref. | Ref. | Ref. | Ref. | |||||||
LSP/11p15.5 | CT | 225/228 | 1.08 | (0.81-1.43) | 1.04 | (0.77‒1.42) | 88/106 | 0.76 | (0.49-1.18) | 0.90 | (0.55-1.47) | 95/114 | 1.36 | (0.94-1.97) | 1.20 | (0.79-1.83) |
TT | 79/57 | 1.49 | (0.99-2.24) | 1.40 | (0.90‒2.19) | 30/23 | 1.21 | (0.64-2.30) | 1.23 | (0.62-2.48) | 137/122 |
1.72
|
(1.02-2.90)
| 1.69 | (0.94-3.09) | |
Per allele | 1.18 | (0.97-1.42) | 1.15 | (0.93‒1.41) | 0.98 | (0.72-1.32) | 1.11 | (0.81-1.52) | 49/34 |
1.32
|
(1.03-1.69)
| 1.24 | (0.95-1.63) | |||
rs30099 | CC | 225/216 | Ref. | Ref. | 93/84 | Ref. | Ref. | Ref. | Ref. | |||||||
/5q | TC | 205/198 | 0.82 | (0.52-1.29) | 1.08 | (0.80‒1.45) | 82/84 | 0.87 | (0.57-1.33) | 0.96 | (0.61-1.53) | 132/132 | 1.08 | (0.76-1.54) | 1.21 | (0.80-1.83) |
TT | 42/50 | 0.99 | (0.76-1.30) | 0.86 | (0.52‒1.41) | 15/25 | 0.53 | (0.26-1.06) | 0.51 | (0.24-1.08) | 123/114 | 1.12 | (0.61-2.06) | 1.19 | (0.58-2.45) | |
Per allele | 0.93 | (0.76-1.13) | 0.98 | (0.79‒1.22) | 0.78 | (0.57-1.06) | 0.85 | (0.92-1.16) | 27/25 | 1.04 | (0.81-1.36) | 1.12 | (0.83-1.50) | |||
rs2981282 | CC | 220/226 | Ref. | Ref. | 86/94 | Ref. | Ref. | Ref. | Ref. | |||||||
FGFR2 /10q26 | TC | 210/190 | 1.15 | (0.87-1.50) | 1.19 | (0.89‒1.60) | 91/81 | 1.23 | (0.81-1.87) | 1.48 | (0.94-2.35) | 134/132 | 1.10 | (0.77-1.58) | 1.08 | (0.72-1.62) |
TT | 41/45 | 0.92 | (0.58-1.47) | 0.84 | (0.50‒1.40) | 13/17 | 0.89 | (0.41-1.92) | 1.07 | (0.46-2.50) | 119/109 | 0.95 | (0.53-1.71) | 0.76 | (0.38-1.48) | |
Per allele | 1.03 | (0.84-1.25) | 1.02 | (0.82‒1.27) | 1.04 | (0.75-1.43) | 1.27 | (0.91-1.78) | 28/28 | 1.04 | (0.80-1.34) | 0.94 | (0.71-1.24) | |||
rs795399 | TT | 255/249 | Ref. | Ref. | 90/107 | Ref. | Ref. | Ref. | Ref. | |||||||
IGF1/12q23.2 | CT | 180/173 | 0.84 | (0.51-1.36) | 1.05 | (0.78‒1.41) | 82/65 | 1.49 | (0.97-2.30) | 1.56 | (0.98-2.48) | 165/142 | 0.80 | (0.56-1.15) | 0.78 | (0.52-1.18) |
CC | 34/41 | 1.03 | (0.78-1.35) | 0.85 | (0.49‒1.45) | 15/20 | 0.86 | (0.41-1.77) | 1.04 | (0.46-2.27) | 98/108 | 0.87 | (0.44-1.70) | 0.93 | (0.43-1.99) | |
Per allele | 0.96 | (0.79-1.18) | 0.97 | (0.78‒1.21) | 1.13 | (0.83-1.55) | 1.25 | (0.91-1.72) | 19/21 | 0.87 | (0.66-1.14) | 0.88 | (0.66-1.17) | |||
rs3757318 | GG | 249/281 | Ref. | Ref. | 95/111 | Ref. | Ref. | Ref. | Ref. | |||||||
ESR1/6q25.1 | AG | 182/162 | 1.27 | (0.97-1.67) |
1.25
|
(0.93‒1.69)
| 76/72 | 1.25 | (0.82-1.91) | 1.22 | (0.77-1.92) | 154/170 | 1.27 | (0.88-1.81) | 1.20 | (0.79-1.80) |
AA | 34/19 |
2.01
|
(1.13-3.68)
|
2.05
|
(1.09‒3.97)
| 14/8 | 2.02 | (0.83-5.25) | 1.90 |
(0.73-5.25)
| 106/90 | 1.96 | (0.92-4.37) | 2.14 |
(0.88-5.49)
| |
Per allele |
1.34
|
(1.08-1.66)
|
1.33
|
(1.05‒1.69)
| 1.30 | (0.93-1.83) | 1.34 |
(0.95-1.91)
| 20/11 | 1.32 | (1.00-1.76) | 1.27 |
(0.93-1.75)
|
Risk allele carriers (AA + AG) n = 474 | Non-risk allele carriers (GG) n = 457 | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Case n = 255/Control n = 219 | Case n = 213/Control n = 244 | ||||||||||||||
n/n | ORa(95% CI) | p | ORb(95% CI) | p | n/n | ORa(95% CI) | p | ORc(95% CI) | p | ||||||
Age (years) | 54.0/53.9 | 55.8/53.2 | |||||||||||||
Menopausal status | Pre | 148/133 | 130/137 | ||||||||||||
Post | 107/86 | 83/107 | |||||||||||||
Height (cm) | ≤150 | 40/39 | 1.03 | (0.58-1.83) | 0.93 | 0.96 | (0.53-1.74) | 0.89 | 55/39 | 1.34 | (0.78-2.9) | 0.29 | 1.19 | (0.66-2.14) | 0.57 |
151-155 | 76/77 | Ref. | Ref. | 68/68 | Ref. | Ref. | |||||||||
156-160 | 89/66 | 1.38 | (0.88-2.16) | 0.16 | 1.44 | (0.91-2.29) | 0.12 | 63/89 | 0.76 | (0.48-1.3) | 0.27 | 0.89 | (0.53-1.48) | 0.64 | |
>160 | 46/34 | 1.41 | (0.81-2.47) | 0.23 | 1.62 | (0.91-2.91) | 0.10 | 25/47 | 0.59 | (0.32-1.08) | 0.09 | 0.51 |
(0.25-0.99)
| 0.05 | |
BMI (Kg/m2) | 20 | 59/46 | 1.27 | (0.75-2.14) | 0.37 | 1.13 | (0.67-1.94) | 0.64 | 43/50 | 1.62 | (0.93-2.81) | 0.09 | 1.54 | (0.84-2.82) | 0.16 |
20-21.9 | 69/67 | Ref. | Ref. | 48/82 | Ref. | Ref. | |||||||||
22-23.9 | 58/50 | 1.09 | (0.66-1.80) | 0.75 | 0.97 | (0.58-1.63) | 0.92 | 43/52 | 1.40 | (0.82-2.40) | 0.22 | 1.47 | (0.83-2.63) | 0.19 | |
≥24 | 65/53 | 1.17 | (0.71-1.94) | 0.53 | 1.09 | (0.65-1.82) | 0.74 | 74/59 |
2.07
|
(1.26-3.43)
|
<0.01
|
1.91
|
(1.11-3.29)
|
0.02
| |
Smoking status | Never | 222/201 | Ref. | Ref. | 180/230 | Ref. | Ref. | ||||||||
Current or former | 29/15 | 1.78 | (0.93-3.51) | 0.08 | 1.61 | (0.83-3.21) | 0.16 | 31/13 |
3.82
|
(1.94-7.98)
|
<0.01
|
3.86
|
(1.87-8.37)
|
<0.01
| |
Alcohol drinking | Never | 129/107 | Ref. | Ref. | 108/111 | Ref. | Ref. | ||||||||
Current or former | 125/109 | 0.97 | (0.67-1.40) | 0.97 | 1.07 | (0.73-1.57) | 0.74 | 105/133 | 0.91 | (0.62-1.33) | 0.61 | 0.87 | (0.56-1.33) | 0.51 | |
Alcohol intake (g/day) | 0 | 129/107 | Ref. | Ref. | 108/111 | Ref. | Ref. | ||||||||
<5 | 75/56 | 1.12 | (0.72-1.74) | 0.61 | 1.22 | (0.78-1.92) | 0.39 | 64/73 | 0.99 | (0.64-1.54) | 0.98 | 0.98 | (0.60-1.61) | 0.94 | |
5-10 | 28/32 | 0.75 | (0.42-1.34) | 0.34 | 0.88 | (0.49-1.60) | 0.68 | 25/30 | 0.94 | (0.51-1.72) | 0.85 | 0.92 | (0.46-1.80) | 0.80 | |
10> | 20/19 | 0.88 | (0.44-1.74) | 0.71 | 0.94 | (0.46-1.89) | 0.85 | 16/26 | 0.70 | (0.35-1.38) | 0.31 | 0.55 | (0.24-1.22) | 0.14 | |
Leisure-time exercise | No | 143/97 | Ref. | Ref. | 110/116 | Ref. | Ref. | ||||||||
Yes | 110/121 |
0.62
|
(0.43-0.89)
|
0.01
|
0.60
|
(0.41-0.87)
|
<0.01
| 101/127 | 0.77 | (0.52-1.12) | 0.17 | 0.74 | (0.49-1.11) | 0.14 | |
Intensity of physical activityd (met/week) | 0 | 143/99 | Ref. | Ref. | 109/119 | Ref. | Ref. | ||||||||
>6.0 | 25/23 | 0.79 | (0.42-1.48) | 0.45 | 0.72 | (0.38-1.37) | 0.32 | 25/19 | 1.35 | (0.70-2.63) | 0.37 | 1.20 | (0.59-2.48) | 0.61 | |
6.0-11.9 | 20/28 |
0.49
|
(0.26-0.92)
|
0.03
|
0.46
|
(0.24-0.86)
|
0.02
| 22/32 | 0.63 | (0.34-1.17) | 0.15 | 0.66 | (0.34-1.28) | 0.22 | |
12.0-23.9 | 27/36 |
0.52
|
(0.29-0.91)
|
0.02
|
0.53
|
(0.30-0.94)
|
0.03
| 21/44 |
0.48
|
(0.26-0.85)
|
0.01
|
0.45
|
(0.24-0.83)
|
0.01
| |
≥24.0 | 30/32 | 0.65 | (0.37-1.14) | 0.13 | 0.68 | (0.38-1.20) | 0.18 | 22/29 | 0.74 | (0.40-1.38) | 0.35 | 0.70 | (0.36-1.36) | 0.30 | |
Age at menarche | ≤12 | 70/92 | 0.73 | (0.45-1.19) | 0.73 | 0.72 | (0.44-1.19) | 0.20 | 68/109 | 1.07 | (0.63-1.81) | 0.80 | 0.98 | (0.56-1.70) | 0.93 |
(year) | 13 | 66/55 | Ref. | Ref. | 43/58 | Ref. | Ref. | ||||||||
≤14 | 116/68 | 1.20 | (0.74-1.93) | 1.20 | 1.15 | (0.71-1.89) | 0.57 | 99/75 | 1.32 | (0.78-2.25) | 0.29 | 1.62 | (0.93-2.84) | 0.09 | |
Parity | 0 | 54/35 | Ref. | Ref. | 31/40 | Ref. | Ref. | ||||||||
1-2 | 123/122 | 0.63 | (0.38-1.04) | 0.07 | 0.66 | (0.40-1.10) | 0.11 | 124/143 | 0.95 | (0.55-1.64) | 0.85 | 1.12 | (0.61-2.09) | 0.71 | |
≥3 | 54/53 | 0.65 | (0.36-1.15) | 0.14 | 0.65 | (0.36-1.17) | 0.15 | 46/53 | 0.94 | (0.50-1.76) | 0.84 | 1.29 | (0.64-2.62) | 0.48 | |
Age at first childbirth | <25 | 78/68 | 1.21 | (0.77-1.90) | 0.40 | 1.08 | (0.68-1.71) | 0.74 | 72/74 | 1.22 | (0.78-1.91) | 0.38 | 1.17 | (0.71-1.91) | 0.54 |
(year) | 25-29 | 87/89 | Ref. | Ref. | 75/97 | Ref. | Ref. | ||||||||
≥30 | 33/22 | 1.55 | (0.84-2.90) | 0.16 | 1.45 | (0.77-2.76) | 0.25 | 30/28 | 1.39 | (0.77-2.54) | 0.27 | 1.77 | (0.92-3.45) | 0.09 | |
Breastfeeding | No | 72/51 | Ref. | Ref. | 51/53 | Ref. | Ref. | ||||||||
Yes | 178/165 | 0.76 | (0.50-1.16) | 0.21 | 0.77 | (0.50-1.17) | 0.22 | 159/189 | 0.83 | (0.53-1.30) | 0.42 | 1.02 | (0.62-1.69) | 0.93 | |
Family history of | No | 209/180 | Ref. | Ref. | 178/192 | Ref. | Ref. | ||||||||
Breast cancer | Yes | 31/24 | 1.11 | (0.63-1.97) | 0.55 | 1.12 | (0.63-2.00) | 0.71 | 22/28 | 0.82 | (0.45-1.50) | 0.75 | 1.07 | (0.57-2.05) | 0.83 |
Education | High school or less | 135/99 | Ref. | Ref. | 123/96 | Ref. | Ref. | ||||||||
Two-year college | 81/63 | 0.93 | (0.61-1.42) | 0.74 | 0.95 | (0.62-1.47) | 0.83 | 60/81 |
0.62
|
(0.40-0.95)
|
0.03
|
0.59
|
(0.37-0.94)
|
0.03
| |
University | 36/55 |
0.48
|
(0.29-0.79)
|
<0.01
|
0.48
|
(0.29-0.79)
|
<0.01
| 28/65 |
0.35
|
(0.21-0.59)
|
<0.01
|
0.38
|
(0.22-0.66)
|
<0.01
|
Risk allele carriers(AA + AG) n = 397 | non-risk allele carriers(GG) n = 530 | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Case n = 216/Control n = 181 | Case n = 249/Control n = 281 | ||||||||||||||
n/n | ORa(95%CI) | p | ORb(95% CI) | p | n/n | ORa(95% CI) | p | ORc(95% CI) | p | ||||||
Age (years) | 54.23/53.30 | 55.28/53.76 | |||||||||||||
Menopausal status | Pre | 124/101 | 154/170 | ||||||||||||
Post | 92/80 | 95/111 | |||||||||||||
Height (cm) | ≤150 | 36/28 | 1.24 | (0.66-2.34) | 0.50 | 1.46 | (0.68-3.16) | 0.33 | 58/50 | 1.07 | (0.65-1.77) | 0.78 | 1.01 | (0.60-1.69) | 0.98 |
151-155 | 62/63 | Ref. | Ref. | 84/80 | Ref. | ref. | |||||||||
156-160 | 78/51 | 1.57 | (0.96-260) | 0.07 | 1.57 | (0.86-2.90) | 0.14 | 72/105 | 0.68 | (0.44-1.05) | 0.08 | 0.73 | (0.47-1.15) | 0.18 | |
>160 | 36/38 | 1.00 | (0.55-1.80) | 0.99 | 0.58 | (0.26-1.24) | 0.16 | 34/43 | 0.80 | (0.46-1.39) | 0.43 | 0.89 | (0.50-1.59) | 0.70 | |
BMI(Kg/m2) | <20 | 48/37 | 1.36 | (0.77-2.40) | 0.26 | 1.11 | (0.54-2.29) | 0.77 | 54/59 | 1.57 | (0.95-2.59) | 0.06 | 1.60 | (0.95-2.69) | 0.08 |
20-21.9 | 59/60 | Ref. | Ref. | 54/90 | Ref. | Ref. | |||||||||
22-23.9 | 47/35 | 1.35 | (0.77-2.40) | 0.24 | 1.57 | (0.80-3.12) | 0.19 | 57/66 | 1.41 | (0.86-2.30) | 0.40 | 1.29 | (0.78-2.14) | 0.32 | |
≥24 | 57/48 | 1.18 | (0.69-2.01) | 0.51 | 1.14 | (0.60-2.17) | 0.68 | 81/63 |
2.08
|
(1.29-3.37)
|
<0.01
|
1.89
|
(1.16-3.10)
|
0.01
| |
Smoking status | Never | 186/168 | Ref. | Ref. | 214/262 | Ref. | Ref. | ||||||||
Current or former | 25/11 |
2.15
|
(1.05-4.71)
|
0.04
|
2.73
|
(1.07-7.65)
|
0.04
| 34/17 |
2.82
|
(1.53-5.40)
|
<0.01
|
2.39
|
(1.27-4.65)
|
<0.01
| |
Alcohol drinking | Never | 114/90 | Ref. | Ref. | 124/127 | Ref. | Ref. | ||||||||
Current or former | 101/89 | 0.93 | (0.62-1.39) | 0.71 | 0.99 | (0.60-1.65) | 0.97 | 125/153 | 0.90 | (0.63-1.28) | 0.55 | 0.95 | (0.65-1.38) | 0.78 | |
Alcohol intake | 0 | 114/90 | Ref. | Ref. | 124/127 | Ref. | Ref. | ||||||||
(g/day) | <5 | 59/45 | 1.08 | (0.67-1.76) | 0.75 | 1.12 | (0.61-2.04) | 0.72 | 78/84 | 1.01 | (0.67-1.51) | 0.98 | 1.11 | (0.72-1.70) | 0.64 |
5-10 | 27/27 | 0.81 | (0.44-1.49) | 0.50 | 0.88 | (0.41-1.90) | 0.75 | 25/35 | 0.79 | (0.44-1.41) | 0.43 | 0.89 | (0.49-1.63) | 0.71 | |
10> | 13/16 | 0.65 | (0.29-1.41) | 0.27 | 0.78 | (0.27-2.14) | 0.63 | 22/29 | 0.82 | (0.44-1.52) | 0.54 | 0.66 | (0.33-1.28) | 0.22 | |
Leisure-time | No | 122/80 | Ref. | Ref. | 127/133 | Ref. | Ref. | ||||||||
Exercise | Yes | 93/101 |
0.58
|
(0.39-0.87)
|
<0.01
| 0.78 | (0.47-1.27) | 0.32 | 119/146 | 0.82 | (0.58-1.17) | 0.27 | 0.84 | (0.59-1.21) | 0.35 |
Intensity of physical activityd(met/week) | 0 | 122/81 | Ref. | Ref. | 126/137 | Ref. | Ref. | ||||||||
>6.0 | 23/17 | 0.87 | (0.44-1.76) | 0.70 | 1.62 | (0.68-4.03) | 0.28 | 28/25 | 1.24 | (0.68-2.27) | 0.48 | 1.19 | (0.64-2.25) | 0.58 | |
6.0-11.9 | 21/25 | 0.55 | (0.28-1.04) | 0.07 | 0.58 | (0.27-1.21) | 0.15 | 23/34 | 0.68 | (0.37-1.22) | 0.20 | 0.69 | (0.37-1.28) | 0.24 | |
12.0-23.9 | 19/32 |
0.39
|
(0.20-0.73)
|
<0.01
| 0.73 | (0.33-1.56) | 0.41 | 29/48 | 0.63 | (0.37-1.06) | 0.08 | 0.62 | (0.36-1.06) | 0.08 | |
≥24.0 | 23/26 | 0.56 | (0.29-1.06) | 0.07 | 0.67 | (0.31-1.42) | 0.29 | 27/35 | 0.79 | (0.45-1.39) | 0.42 | 0.84 | (0.47-1.50) | 0.55 | |
Age at menarche | ≤12 | 63/73 | 1.00 | (0.59-1.70) | 0.99 | 1.67 | (0.85-3.33) | 0.14 | 73/127 | 0.77 | (0.47-1.24) | 0.28 | 0.74 | (0.45-1.22) | 0.24 |
(year) | 13 | 52/51 | Ref. | Ref. | 57/61 | Ref. | Ref. | ||||||||
≤14 | 99/56 | 1.39 | (0.82-2.35) | 0.22 | 1.74 | (0.90-3.37) | 0.10 | 115/88 | 1.12 | (0.70-1.81) | 0.63 | 1.02 | (0.62-1.68) | 0.92 | |
Parity | 0 | 49/24 | Ref. | Ref. | 37/50 | Ref. | Ref. | ||||||||
1-2 | 110/105 |
0.48
|
(0.27-0.84)
|
<0.01
| 0.55 | (0.19-1.54) | 0.25 | 132/160 | 0.98 | (0.60-1.62) | 0.95 | 1.19 | (0.70-2.05) | 0.52 | |
≥3 | 36/48 |
0.34
|
(0.17-0.65)
|
<0.01
| 0.35 | (0.12-1.04) | 0.06 | 65/58 | 1.36 | (0.77-2.40) | 0.29 | 1.74 | (0.95-3.21) | 0.07 | |
Age at first childbirth | <25 | 60/60 | 1.05 | (0.64-1.71) | 0.86 | 0.97 | (0.56-1.66) | 0.90 | 88/82 | 1.35 | (0.89-2.05) | 0.15 | 1.19 | (0.77-1.84) | 0.43 |
(year) | 25-29 | 72/77 | 88/110 | Ref. | Ref. | ||||||||||
≥30 | 34/19 |
1.96
|
(1.03-3.80)
|
0.04
| 1.82 | (0.88-3.85) | 0.11 | 29/31 | 1.17 | (0.66-2.10) | 0.59 | 1.27 | (0.69-2.33) | 0.45 | |
Breastfeeding | No | 65/38 | Ref. | Ref. | 59/65 | Ref. | Ref. | ||||||||
Yes | 150/143 |
0.60
|
(0.38-0.95)
|
0.03
| 0.93 | (0.36-2.43) | 0.89 | 183/211 | 0.91 | (0.61-1.38) | 0.67 | 1.07 | (0.69-1.65) | 0.77 | |
Family history of | No | 173/143 | Ref. | Ref. | 212/229 | Ref. | Ref. | ||||||||
Breast cancer | Yes | 24/19 | 1.04 | (0.55-2.00) | 0.79 | 1.30 | (0.56-3.07) | 0.54 | 28/33 | 0.91 | (0.53-1.57) | 0.93 | 0.90 | (0.51-1.58) | 0.72 |
Education | High school or less | 113/80 | Ref. | Ref. | 144/115 | Ref. | Ref. | ||||||||
Two-year college | 74/54 | 0.99 | (0.62-1.57) | 0.96 | 1.02 | (0.58-1.79) | 0.94 | 66/90 |
0.60
|
(0.40-0.91)
|
0.01
|
0.63
|
(0.42-0.96)
|
0.03
| |
University | 27/45 |
0.43
|
(0.24-0.76)
|
<0.01
|
0.33
|
(0.16-0.67)
|
0.00
| 36/74 |
0.40
|
(0.25-0.64)
|
<0.01
|
0.45
|
(0.28-0.73)
|
<0.01
|