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Erschienen in: Journal of Bone and Mineral Metabolism 5/2020

29.04.2020 | Original Article

Effects of mild hyperbaric oxygen on osteoporosis induced by hindlimb unloading in rats

verfasst von: Ai Takemura, Paola Divieti Pajevic, Tatsuro Egawa, Rika Teshigawara, Tatsuya Hayashi, Akihiko Ishihara

Erschienen in: Journal of Bone and Mineral Metabolism | Ausgabe 5/2020

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Abstract

Introduction

Disuse-induced bone loss is caused by a suppression of osteoblastic bone formation and an increase in osteoclastic bone resorption. There are few data available for the effects of environmental conditions, i.e., atmospheric pressure and/or oxygen concentration, on osteoporosis. This study examined the effects of mild hyperbaric oxygen at 1317 hPa with 40% oxygen on unloading-induced osteoporosis.

Materials and methods

Eighteen 8-week old male Wistar rats were randomly divided into three groups: the control for 21 days without unloading and mild hyperbaric oxygen (NOR, n = 6), the unloading for 21 days and recovery for 10 days without mild hyperbaric oxygen (HU + NOR, n = 6), and the unloading for 21 days and recovery for 10 days with mild hyperbaric oxygen (HU + MHO, n = 6).

Results

The cortical thickness and trabecular bone surface area were decreased in the HU + NOR group compared to the NOR group. There were no differences between the NOR and HU + MHO groups. Osteoclast surface area and Sclerostin (Sost) mRNA expression levels were decreased in the HU + MHO group compared to the HU + NOR group. These results suggested that the loss of the cortical and trabecular bone is inhibited by mild hyperbaric oxygen, because of an inhibition of osteoclasts and enhancement of bone formation with decreased Sost expression.

Conclusions

We conclude that exposure to mild hyperbaric oxygen partially protects from the osteoporosis induced by hindlimb unloading.
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Metadaten
Titel
Effects of mild hyperbaric oxygen on osteoporosis induced by hindlimb unloading in rats
verfasst von
Ai Takemura
Paola Divieti Pajevic
Tatsuro Egawa
Rika Teshigawara
Tatsuya Hayashi
Akihiko Ishihara
Publikationsdatum
29.04.2020
Verlag
Springer Singapore
Erschienen in
Journal of Bone and Mineral Metabolism / Ausgabe 5/2020
Print ISSN: 0914-8779
Elektronische ISSN: 1435-5604
DOI
https://doi.org/10.1007/s00774-020-01100-6

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20.06.2024 ST-Hebungsinfarkt Nachrichten

Wie hoch ist bei Patienten, die nach einem ST-Hebungs-Myokardinfarkt die initiale Hochrisikophase überleben, auf lange Sicht das Sterberisiko? Eine Studie aus Dänemark liefert dazu nun aufschlussreiche Daten.

Update Innere Medizin

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