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11.12.2019 | Original Article

Effects of omega-3 fatty acids supplementation on inflammatory parameters after chronic administration of L-tyrosine

verfasst von: Rafaela Antonini, Giselli Scaini, Monique Michels, Mariane B. D. Matias, Patrícia F. Schuck, Gustavo C. Ferreira, Jade de Oliveira, Felipe Dal-Pizzol, Emilio L. Streck

Erschienen in: Metabolic Brain Disease | Ausgabe 2/2020

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Abstract

Tyrosinemia type II is an autosomal recessive inborn error of metabolism caused by hepatic cytosolic tyrosine aminotransferase deficiency. Importantly, this disease is associated with neurological and developmental abnormalities in many patients. Considering that the mechanisms underlying neurological dysfunction in hypertyrosinemic patients are poorly understood, in the present work we investigated the levels of cytokines – tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6 and IL-10 - in cerebellum, hippocampus, striatum of young rats exposed to chronic administration of L-tyrosine. In addition, we also investigated the impact of the supplementation with Omega-3 fatty acids (n-3 PUFA) on the rodent model of Tyrosinemia. Notably, previous study demonstrated an association between L-tyrosine toxicity and n-3 PUFA deficiency. Our results showed a significant increase in the levels of pro- and anti-inflammatory cytokines in brain structures when animals were administered with L-tyrosine. Cerebral cortex and striatum seem to be more susceptible to the inflammation induced by tyrosine toxicity. Importantly, n-3 PUFA supplementation attenuated the alterations on cytokines levels induced by tyrosine exposure in brain regions of infant rats. In conclusion, the brain inflammation is also an important process related to tyrosine neurotoxicity observed in the experimental model of Tyrosinemia. Finally, n-3 PUFA supplementation could be considered as a potential neuroprotective adjunctive therapy for Tyrosinemias, especially type II.

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Titel: Effects of omega-3 fatty acids supplementation on inflammatory parameters after chronic administration of L-tyrosine
verfasst von: Rafaela Antonini
Giselli Scaini
Monique Michels
Mariane B. D. Matias
Patrícia F. Schuck
Gustavo C. Ferreira
Jade de Oliveira
Felipe Dal-Pizzol
Emilio L. Streck
Publikationsdatum: 11.12.2019
Verlag: Springer US
Erschienen in: Metabolic Brain Disease / Ausgabe 2/2020
Print ISSN: 0885-7490
Elektronische ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-019-00525-x

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Effects of omega-3 fatty acids supplementation on inflammatory parameters after chronic administration of L-tyrosine

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