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01.12.2014 | Study protocol | Ausgabe 1/2014 Open Access

BMC Geriatrics 1/2014

Effects of omega 3 supplementation in elderly patients with acute myocardial infarction: design of a prospective randomized placebo controlled study

Zeitschrift:
BMC Geriatrics > Ausgabe 1/2014
Autoren:
Kristian Laake, Peder Myhre, Linn M Nordby, Ingebjørg Seljeflot, Michael Abdelnoor, Pål Smith, Arnljot Tveit, Harald Arnesen, Svein Solheim
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1471-2318-14-74) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

KL conducts the study and is responsible for analysis and interpretation of the data, drafted and revised the manuscript. PM and LMN conducts the study, will contribute to the interpretation of the results and revised the manuscript. MA made contributions to the statistics used, study protocol and design. IS and HA conceived of the study, contributed to the study protocol, obtained funding and discussed the manuscript. PS and AT contributed to the study design and protocol and assists in the data collection. SS coordinates the study and made substantial contribution to the study protocol, will contribute to data analysis and intepretation, and revised the manuscript. All the authors contributed to revision and approval of the final manuscript.

Abstract

Background

Both epidemiological and randomized clinical studies suggest that supplementation with very-long-chain marine polyunsaturated n-3 fatty acids (n-3 PUFA) have cardioprotective effects, however these results are not without controversy. Study population, sample-size, type of supplementation and type of endpoint have all varied widely accross different studies.
Therefore, the aims of the present study are to evaluate the effect of 2 years supplementation with capsules of very-long chain marine n-3 PUFA on top of standard therapy in elderly patients after acute myocardial infarction (AMI).
In addition, special characteristics of this population with regard to prediction of clinical outcome will be investigated. The hypothesis is that this supplementation on top of modern therapy will reduce the occurence of major cardiovascular events (MACE). We present the design of the OMEMI (OMega-3 fatty acids in Elderly patients with Myocardial Infarction) study.

Methods/Design

The OMEMI study is designed as a randomized, placebo-controlled double-blind multicenter trial.
Included are patients ≥70-82 years of age who have sustained AMI. Patients of either gender are eligible. Sample size calculation based on existing literature has resulted in the need for 1400 patients followed for 2 years, based on the assumption that the n-3 PUFA supplementation will reduce MACE with 30%. The study medication is Pikasol® Axellus AS, Norway, 3 capsules (1.8 g eicosapentaenoic acid (EPA) + docohexaenoic acid (DHA)) per day, and matching placebo is corn oil. The Primary end-point is the composite of total mortality, first non-fatal recurring AMI, stroke and revascularization. Secondary end-point is the occurrence of new onset atrial fibrillation. Extensive biobanking will be performed, including adipose tissue biopsies. Compliance will be assessed by measurements of the fatty acid profile in serum, sampled at inclusion, after 12 months and at the end of study.

Discussion

The OMEMI study is scheduled to terminate when the last included patient has been followed for 2 years. To the best of our knowledge, the OMEMI study is the first to evaluate the effect of n-3 PUFAs on CVDs and mortality in a high risk elderly population having suffered an acute myocardial infarction.

Trial registration

ClinicalTrials.gov, NCT01841944
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