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Erschienen in:

03.04.2024 | Clinical Report

Effects of palliative intrathecal analgesia on patients with refractory cancer bone pain

verfasst von: Isao Haraga, Toshifumi Kosugi, Eiji Sadashima, Tomoko Yumiba, Mayuko Kubo, Asako Ishikawa-Konishi, Kozaburo Akiyoshi

Erschienen in: Journal of Anesthesia | Ausgabe 3/2024

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Abstract

This study examined the effects of intrathecal analgesia (ITA) using an extracorporeal pump with a subcutaneous port system in cancer patients with bone metastasis. Among the patients who died of cancer with bone metastasis at the palliative care unit of our institution, 11 who received ITA were selected. Changes in pain, opioid doses, the palliative prognostic index (PPI), and Eastern Cooperative Oncology Group Performance Scale after ITA were assessed. Pain, opioid doses, and PPI decreased after ITA (P = 0.002, 0.002, and 0.017). ITA for cancer patients with increased PPI due to refractory cancer bone pain decreased pain, opioid doses, and PPI.
(100 words).
Literatur
1.
Zurück zum Zitat Dong D, Zhao M, Zhang J, Huang M, Wang Y, Qi L, Wan CF, Yu X, Song T. Neurolytic splanchnic nerve block and pain relief, survival, and quality of life in unresectable pancreatic cancer: a randomized controlled trial. Anesthesiology. 2021;135:689–98.CrossRef Dong D, Zhao M, Zhang J, Huang M, Wang Y, Qi L, Wan CF, Yu X, Song T. Neurolytic splanchnic nerve block and pain relief, survival, and quality of life in unresectable pancreatic cancer: a randomized controlled trial. Anesthesiology. 2021;135:689–98.CrossRef
2.
Zurück zum Zitat Fujii-Lau LL, Bamlet WR, Eldrige JS, Chari ST, Gleeson FC, Abu Dayyeh BK, Clain JE, Pearson RK, Petersen BT, Rajan E, Topazian MD, Vege SS, Wang KK, Wiersema MJ, Levy MJ. Impact of celiac neurolysis on survival in patients with pancreatic cancer. Gastrointest Endosc. 2015;82:46–56.CrossRefPubMedPubMedCentral Fujii-Lau LL, Bamlet WR, Eldrige JS, Chari ST, Gleeson FC, Abu Dayyeh BK, Clain JE, Pearson RK, Petersen BT, Rajan E, Topazian MD, Vege SS, Wang KK, Wiersema MJ, Levy MJ. Impact of celiac neurolysis on survival in patients with pancreatic cancer. Gastrointest Endosc. 2015;82:46–56.CrossRefPubMedPubMedCentral
3.
Zurück zum Zitat Rathmell JP, Rickerson EM, Tulsky JA, Lillemoe KD. Reassessing the role for sympathetic neurolysis in patients with pancreatic cancer. Anesthesiology. 2021;135:573–5.CrossRefPubMed Rathmell JP, Rickerson EM, Tulsky JA, Lillemoe KD. Reassessing the role for sympathetic neurolysis in patients with pancreatic cancer. Anesthesiology. 2021;135:573–5.CrossRefPubMed
5.
Zurück zum Zitat Anderson F, Downing GM, Hill J, Casorso L, Lerch N. Palliative performance scale (PPS): a new tool. J Palliat Care. 1996;12:5–11.CrossRefPubMed Anderson F, Downing GM, Hill J, Casorso L, Lerch N. Palliative performance scale (PPS): a new tool. J Palliat Care. 1996;12:5–11.CrossRefPubMed
6.
Zurück zum Zitat Morita T, Tsunoda J, Inoue S, Chihara S. The palliative prognostic index: a scoring system for survival prediction of terminally ill cancer patients. Support Care Cancer. 1999;7:128–33.CrossRefPubMed Morita T, Tsunoda J, Inoue S, Chihara S. The palliative prognostic index: a scoring system for survival prediction of terminally ill cancer patients. Support Care Cancer. 1999;7:128–33.CrossRefPubMed
7.
Zurück zum Zitat De Iaco F, Mannaioni G, Serra S, Finco G, Sartori S, Gandolfo E, Sansone P, Marinangelii F. Equianalgesia, opioid switch and opioid association in different clinical settings: a narrative review. Eur Rev Med Pharmacol Sci. 2022;26:2000–17.PubMed De Iaco F, Mannaioni G, Serra S, Finco G, Sartori S, Gandolfo E, Sansone P, Marinangelii F. Equianalgesia, opioid switch and opioid association in different clinical settings: a narrative review. Eur Rev Med Pharmacol Sci. 2022;26:2000–17.PubMed
8.
Zurück zum Zitat Takakuwa O, Oguri T, Maeno K, Murase H, Asano T, Ichikawa H, Kawaguchi Y, Uemura T, Ohkubo H, Takemura M, Niimi A. Long-term use of a once-a day fentanyl citrate transdermal patch in lung cancer patients. Oncol Lett. 2015;9:2105–8.CrossRefPubMedPubMedCentral Takakuwa O, Oguri T, Maeno K, Murase H, Asano T, Ichikawa H, Kawaguchi Y, Uemura T, Ohkubo H, Takemura M, Niimi A. Long-term use of a once-a day fentanyl citrate transdermal patch in lung cancer patients. Oncol Lett. 2015;9:2105–8.CrossRefPubMedPubMedCentral
9.
Zurück zum Zitat Williamson A, Hoggart B. Pain: a review of three commonly used pain rating scales. J Clin Nurs. 2005;14:798–804.CrossRefPubMed Williamson A, Hoggart B. Pain: a review of three commonly used pain rating scales. J Clin Nurs. 2005;14:798–804.CrossRefPubMed
10.
Zurück zum Zitat World Health Organization. Cancer pain relief. 2nd ed. Geneva: World Health Organization; 1996. World Health Organization. Cancer pain relief. 2nd ed. Geneva: World Health Organization; 1996.
12.
Zurück zum Zitat Sjöberg M, Nitescu P, Appelgren L, Curelaru I. Long-term intrathecal morphine and bupivacaine in patients with refractory cancer pain. Results from a morphine: bupivacaine dose regimen of 0.5: 4.75 mg/ml. Anesthesiology. 1994;80:284–97.CrossRefPubMed Sjöberg M, Nitescu P, Appelgren L, Curelaru I. Long-term intrathecal morphine and bupivacaine in patients with refractory cancer pain. Results from a morphine: bupivacaine dose regimen of 0.5: 4.75 mg/ml. Anesthesiology. 1994;80:284–97.CrossRefPubMed
13.
Zurück zum Zitat Nitescu P, Appelgren L, Hultman E, Linder LE, Sjögern M, Curelaru I. Long-term, open catheterization of the spinal subarachnoid space for continuous infusion of narcotic and bupivacaine in patients with “refractory” cancer pain. a technique of catheterization and its problems and complications. Clin J Pain. 1991;7:143–61.CrossRefPubMed Nitescu P, Appelgren L, Hultman E, Linder LE, Sjögern M, Curelaru I. Long-term, open catheterization of the spinal subarachnoid space for continuous infusion of narcotic and bupivacaine in patients with “refractory” cancer pain. a technique of catheterization and its problems and complications. Clin J Pain. 1991;7:143–61.CrossRefPubMed
15.
Zurück zum Zitat Yan BM, Myers RP. Neurolytic celiac plexus block for pain control in unresectable pancreatic cancer. Am J Gastroenterol. 2007;102:430–8.CrossRefPubMed Yan BM, Myers RP. Neurolytic celiac plexus block for pain control in unresectable pancreatic cancer. Am J Gastroenterol. 2007;102:430–8.CrossRefPubMed
17.
Zurück zum Zitat Süleyman Ozyalçin N, Talu GK, Camlica H, Erdine S. Efficacy of coeliac plexus and splanchnic nerve blockades in body and tail located pancreatic cancer pain. Eur J Pain. 2004;8:539–45.CrossRefPubMed Süleyman Ozyalçin N, Talu GK, Camlica H, Erdine S. Efficacy of coeliac plexus and splanchnic nerve blockades in body and tail located pancreatic cancer pain. Eur J Pain. 2004;8:539–45.CrossRefPubMed
18.
Zurück zum Zitat Nomak H, Szwacka DM, Pater M, Mrugalski WK, Milcrarek MG, Staniszewska M, Jankowski R, Barciszewska AM. Holistic approach to the diagnosis and treatment of patients with tumor metastases to the spine. Cancers. 2022;14:3480.CrossRef Nomak H, Szwacka DM, Pater M, Mrugalski WK, Milcrarek MG, Staniszewska M, Jankowski R, Barciszewska AM. Holistic approach to the diagnosis and treatment of patients with tumor metastases to the spine. Cancers. 2022;14:3480.CrossRef
19.
Zurück zum Zitat Smith TJ, Staats PS, Deer T, Stearns LJ, Rauck RL, Boortz-Marx RL, Buchser E, Català E, Bryce DA, Coyne PJ, Pool GE, Implantable Drug Delivery System Study Group. Randomized clinical trial of an implantable drug delivery system compared with comprehensive medical management for refractory cancer pain: impact on pain, drug-related toxicity, and survival. J Clin Oncol. 2002. https://doi.org/10.1200/JCO.2002.02.118.CrossRef Smith TJ, Staats PS, Deer T, Stearns LJ, Rauck RL, Boortz-Marx RL, Buchser E, Català E, Bryce DA, Coyne PJ, Pool GE, Implantable Drug Delivery System Study Group. Randomized clinical trial of an implantable drug delivery system compared with comprehensive medical management for refractory cancer pain: impact on pain, drug-related toxicity, and survival. J Clin Oncol. 2002. https://​doi.​org/​10.​1200/​JCO.​2002.​02.​118.CrossRef
20.
Zurück zum Zitat Davis MP, Walsh D, Lagman R, LeGrand SB. Randomized clinical trial of an implantable drug delivery system. J Clin Oncol. 2003;15:2800–1.CrossRef Davis MP, Walsh D, Lagman R, LeGrand SB. Randomized clinical trial of an implantable drug delivery system. J Clin Oncol. 2003;15:2800–1.CrossRef
21.
Zurück zum Zitat Ripamonti C, Brunelli C. Randomized clinical trial of an implantable drug delivery system compared with comprehensive medical management for refractory cancer pain: impact on pain, drug-related toxicity, and survival. J Clin Oncol. 2003;15:2801–2.CrossRef Ripamonti C, Brunelli C. Randomized clinical trial of an implantable drug delivery system compared with comprehensive medical management for refractory cancer pain: impact on pain, drug-related toxicity, and survival. J Clin Oncol. 2003;15:2801–2.CrossRef
Metadaten
Titel
Effects of palliative intrathecal analgesia on patients with refractory cancer bone pain
verfasst von
Isao Haraga
Toshifumi Kosugi
Eiji Sadashima
Tomoko Yumiba
Mayuko Kubo
Asako Ishikawa-Konishi
Kozaburo Akiyoshi
Publikationsdatum
03.04.2024
Verlag
Springer Nature Singapore
Erschienen in
Journal of Anesthesia / Ausgabe 3/2024
Print ISSN: 0913-8668
Elektronische ISSN: 1438-8359
DOI
https://doi.org/10.1007/s00540-024-03338-0

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