The online version of this article (https://doi.org/10.1186/s12885-017-3970-5) contains supplementary material, which is available to authorized users.
Physical activity is consistently associated with a reduced risk of colorectal cancer in epidemiologic studies. This association among higher risk subgroups, such as those with a first-degree family history of colorectal cancer or high body mass index remains unclear.
We searched MEDLINE for studies examining physical activity and colorectal cancer risk among higher risk subgroups through July 11, 2017. Fifteen and three studies were eligible for inclusion for body mass index and first-degree family history of colorectal cancer subgroups, respectively. Estimates of the highest to lowest comparison of physical activity for each subgroup of risk were pooled using random-effects models.
The pooled associations of physical activity and colorectal cancer risk for those without and with a first-degree family history of colorectal cancer were 0.56 (95% confidence interval (CI) = 0.39–0.80) and 0.72 (95% CI = 0.39–1.32), respectively (pheterogeneity = 0.586). The pooled associations of physical activity and colorectal cancer risk for the low and high body mass index groups were 0.74 (95% CI = 0.66–0.83) and 0.65 (95% CI = 0.53–0.79), respectively (pheterogeneity = 0.389).
Overall, a stronger relative risk of physical activity on colorectal cancer risk was observed in the higher body mass index group, although the difference was not statistically significant, suggesting an added benefit of physical activity as a cancer prevention strategy in population groups with strong risk factors for colorectal cancer. Additional research among these subgroups is warranted.
Additional file 1: Tables S1-S3. PubMed search strategy for systematic review, Newcastle-Ottawa Scale for study quality assessment, and sensitivity analysis for individual study removal. (DOCX 21 kb)12885_2017_3970_MOESM1_ESM.docx
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- Effects of physical activity on colorectal cancer risk among family history and body mass index subgroups: a systematic review and meta-analysis
Megan S. Farris
Chelsea R. Stone
Jeroen W. G. Derksen
Robert J. Hilsden
Christine M. Friedenreich
Darren R. Brenner
- BioMed Central
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