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05.06.2019 | Original Article

Effects of red and near-infrared LED light therapy on full-thickness skin graft in rats

Zeitschrift:
Lasers in Medical Science
Autoren:
Cintia Cristina Santi Martignago, Carla Roberta Tim, Lívia Assis, Viviane Ribeiro Da Silva, Estefany Camila Bonfim Dos Santos, Fabiana Nascimento Vieira, Nivaldo Antonio Parizotto, Richard Eloin Liebano
Wichtige Hinweise
Cintia Cristina Santi Martignago and Carla Roberta Tim contributed equally to this work.

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Abstract

The aim of the present study was to evaluate the in vivo response of different wavelengths (red and near-infrared) of light-emitting diode (LED) on full-thickness skin grafts (FTSG) in rats. Thirty rats were randomly allocated into three experimental groups: control group (C); red LED treated group (R); and near-infrared LED group (NIR). Skin grafts were irradiated daily for ten consecutive days, starting immediately after the surgery using a red (630 nm) or near-infrared (850 nm) LED. The results showed that the red wavelength LED significantly enhanced the skin graft score in relation to the NIR group and increased transforming growth factor beta (TGF-β) protein expression and density of collagen fibers compared with the other experimental groups. These results suggest that the red wavelength LED was efficient to improve the dermo-epidermal junction and modulate the expression proteins related to tissue repair.

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