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Annals of Nuclear Medicine
Erschienen in: Annals of Nuclear Medicine 7/2018

17.05.2018 | Original Article

Effects of rs591323 on serotonin transporter availability in healthy male subjects

verfasst von: Kyoungjune Pak, Hyun-Yeol Nam, Seunghyeon Shin, Keunyoung Kim, Myung Jun Lee, Eun-Joo Kim, Jae Meen Lee, Seong-Jang Kim, In Joo Kim

Erschienen in: Annals of Nuclear Medicine | Ausgabe 7/2018

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Abstract

Objectives

We aimed to investigate the association between genetic factors of SNPs dopamine transporter (DAT) and serotonin transporter (SERT) availabilities in healthy controls.

Methods

The study population consisted of healthy controls with screening 123I-FP-CIT single-photon emission computed tomography. Specific binding of 123I-FP-CIT regarding DAT and SERT was calculated using a region of interest analysis. VOI template was applied to measure specific binding ratios (SBRs) of caudate nucleus, putamen, striatum, midbrain, and pons.

Results

One hundred sixty healthy controls (male 106, female 54, 61.0 ± 11.5 years) were included in this study. Sex difference did not exist in DAT availabilities of caudate nucleus (p = 0.5344), putamen (p = 0.5006), and striatum (p = 0.5056). However, male subjects had higher SERT availabilities of both midbrain (p = 0.0436), and pons (p = 0.0061). Therefore, we analyzed the effect of SNP on DAT availabilities of subjects in all, and that on SERT availabilities of males and females separately. None of 19 SNPs included in this study showed the effect on DAT availabilities. However, rs591323 in Fibroblast Growth Factor 20 on chromosome 8 had a significant impact on SERT availability of both midbrain (p = 0.0056) and pons (p = 0.0007).

Conclusion

SNP rs591323 of risk loci for Parkinson’s disease is associated with SERT availability of healthy male subjects.
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Metadaten
Titel
Effects of rs591323 on serotonin transporter availability in healthy male subjects
verfasst von
Kyoungjune Pak
Hyun-Yeol Nam
Seunghyeon Shin
Keunyoung Kim
Myung Jun Lee
Eun-Joo Kim
Jae Meen Lee
Seong-Jang Kim
In Joo Kim
Publikationsdatum
17.05.2018
Verlag
Springer Japan
Erschienen in
Annals of Nuclear Medicine / Ausgabe 7/2018
Print ISSN: 0914-7187
Elektronische ISSN: 1864-6433
DOI
https://doi.org/10.1007/s12149-018-1262-z

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