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26.03.2021 | Sleep Breathing Physiology and Disorders • Review

Effects of sleep apnea hypopnea syndromes on cardiovascular events: a systematic review and meta-analysis

verfasst von: Liang Xie, Penghao Zhen, Fuchao Yu, Xiaojin Yu, Hai Qian, Fang Yang, Jiayi Tong

Erschienen in: Sleep and Breathing | Ausgabe 1/2022

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Abstract

Purpose

Previous studies suggest that sleep apnea hypopnea syndrome (SAHS) is an independent risk factor that contributes to certain cardiovascular events. However, there are studies arguing that patients with SAHS had lower peak troponin levels when suffering cardiovascular events compared to patients without SAHS, which indicates that there may potentially be a protective effect of SAHS. This meta-analysis aimed to assess the impact of SAHS on cardiovascular events.

Methods

Databases were searched for studies that examined cardiac biomarkers or reported angiographic data when patients with SAHS experienced cardiovascular events. The data about peak cardiac biomarkers and angiographic coronary lesion were extracted and then used to compute the pooled standardized mean difference (SMD) and 95% confidence interval (95% CI).

Results

Among 26 studies included in the meta-analysis, there was not a definite difference between the SAHS group and the control group for troponins (SMD, 0.05; 95% CI, [− 0.16, 0.26]), creatine kinase (SMD, − 0.08; 95% CI, [− 0.38, 0.22]), and CK-MB (SMD, − 0.11; 95% CI, [− 0.51, 0.29]). However, patients with SAHS revealed worse coronary lesion condition grading via both Gensini score (SMD, 0.63; 95% CI, [0.31, 0.95]) and SYNTAX score (SMD, 0.99; 95% CI, [0.31–1.67]).

Conclusions

Ischemic preconditioning induced by the intermittent hypoxia at the early stage could generate a cardiac protection effect, which would then benefit SAHS patients encountering a major adverse cardiovascular event.

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Titel: Effects of sleep apnea hypopnea syndromes on cardiovascular events: a systematic review and meta-analysis
verfasst von: Liang Xie
Penghao Zhen
Fuchao Yu
Xiaojin Yu
Hai Qian
Fang Yang
Jiayi Tong
Publikationsdatum: 26.03.2021
Verlag: Springer International Publishing
Erschienen in: Sleep and Breathing / Ausgabe 1/2022
Print ISSN: 1520-9512
Elektronische ISSN: 1522-1709
DOI: https://doi.org/10.1007/s11325-021-02294-3

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Effects of sleep apnea hypopnea syndromes on cardiovascular events: a systematic review and meta-analysis

Abstract

Purpose

Methods

Results

Conclusions

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Parodontalbehandlung verbessert Prognose bei Katheterablation

Antihypertensiva schützen auch alte Menschen noch vor Demenz

Stereotaktische Radiatio schlägt konventionelle Bestrahlung

Denken Sie bei starker Blutung auch an die Hemmkörper-Hämophilie

Update Innere Medizin

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

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