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Erschienen in: Child's Nervous System 3/2020

01.03.2020 | Original Article

Effects of supratentorial and infratentorial tumor location on cognitive functioning of children with brain tumor

verfasst von: Claudia Corti, Cosimo Urgesi, Maura Massimino, Lorenza Gandola, Alessandra Bardoni, Geraldina Poggi

Erschienen in: Child's Nervous System | Ausgabe 3/2020

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Abstract

Purpose

Effects of tumor location on cognitive performance of patients with brain tumor are controversial: some studies reported higher risks related to supratentorial locations, some to infratentorial locations, and still others did not find any differences. We aimed to address this issue by comparing school-aged children with supratentorial or infratentorial tumor with respect not only to cognitive outcomes but also to the associations between core cognitive domains and academic abilities.

Methods

32 children with infratentorial tumor and 22 with supratentorial tumor participated in the study. To detect relationships among cognitive domains, we tested which neuropsychological variable(s) predicted academic skills, controlling for the effects of radiotherapy and time since diagnosis.

Results

Radiotherapy and time since diagnosis, but not tumor location, predicted cognitive outcomes. Radiotherapy negatively influenced attention and executive functioning, as well as reading speed and arithmetic operations accuracy. Unexpectedly, longer time since diagnosis was associated with improvement in attention and reading speed. Tumor location showed an effect on the relationships between core cognitive domains and academic skills: verbal and visual-spatial memory influenced reading and mathematical performance in supratentorial patients; in infratentorial patients, an only effect of visual-spatial memory on mathematical performance was detected.

Conclusions

Tumor location seems not to influence cognitive performance, while radiotherapy constitutes a key risk factor for cognitive impairment. Attentional and reading abilities may improve over time, possibly due to the weakening of cancer care effects. Different patterns of cognitive associations seem to characterize supratentorial and infratentorial patients, probably associated with different neuroplastic reorganization processes after tumor occurrence.
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Metadaten
Titel
Effects of supratentorial and infratentorial tumor location on cognitive functioning of children with brain tumor
verfasst von
Claudia Corti
Cosimo Urgesi
Maura Massimino
Lorenza Gandola
Alessandra Bardoni
Geraldina Poggi
Publikationsdatum
01.03.2020
Verlag
Springer Berlin Heidelberg
Erschienen in
Child's Nervous System / Ausgabe 3/2020
Print ISSN: 0256-7040
Elektronische ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-019-04434-3

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