Background
Methods/design
Electronic searches
1. | menopause | 7. | androgen |
2. | premenopause | 8. | testosterone |
3. | perimenopause | 9. | epitestosterone |
4. | postmenopause | 10. | hydroxytestosterones |
5. | women | 11. | methyltestosterone |
6. | female | 12. | testosterone propionate |
13. | Population search terms: 1 OR 2 OR 3 OR 4 OR 5 OR 6 | ||
14. | Intervention search terms: 7 OR 8 OR 9 OR 10 OR 11 OR 12 | ||
15. | Final search terms: 13 AND 14 limited by randomised controlled trial and humans |
Searching other resources
Inclusion/exclusion of articles
Types of interventions
Types of outcome measures
Primary outcomes
Secondary outcomes
Summary of findings’ and adverse effects’ table
Data collection and analysis
Selection of studies
Data extraction and management
Dealing with duplicate publications
Assessment of risk of bias in included studies
Measures of treatment effect
Unit of analysis issues
Dealing with missing data
Assessment of heterogeneity
Assessment of reporting biases
Data synthesis
Subgroup analysis and investigation of heterogeneity
-
◦ Restricting the analysis by menopausal status
-
◦ Restricting the analysis by taking into account risk of bias, as specified in the section assessment of risk of bias in included studies
-
◦ Restricting the analysis by the questionnaire validation (validated versus non-validated)
-
◦ Restricting the analysis by treatment duration (at least 12 weeks versus longer duration)
-
◦ Restricting the analysis by mode of drug delivery
-
◦ Restricting the analysis by dose of drug use
-
◦ Restricting the analysis by methods of dealing with attrition bias