Efferocytosis and Bone Dynamics
- 24.06.2024
- REVIEW
Erschienen in:
- Verfasst von
- Lena Batoon
- John R. Hawse
- Laurie K. McCauley
- Megan M. Weivoda
- Hernan Roca
- Erschienen in
- Current Osteoporosis Reports | Ausgabe 5/2024
Abstract
Purpose of Review
This review summarizes the recently published scientific evidence regarding the role of efferocytosis in bone dynamics and skeletal health.
Recent Findings
Several types of efferocytes have been identified within the skeleton, with macrophages being the most extensively studied. Efferocytosis is not merely a 'clean-up' process vital for maintaining skeletal homeostasis; it also plays a crucial role in promoting resolution pathways and orchestrating bone dynamics, such as osteoblast-osteoclast coupling during bone remodeling. Impaired efferocytosis has been associated with aging-related bone loss and various skeletal pathologies, including osteoporosis, osteoarthritis, rheumatoid arthritis, and metastatic bone diseases. Accordingly, emerging evidence suggests that targeting efferocytic mechanisms has the potential to alleviate these conditions.
Summary
While efferocytosis remains underexplored in the skeleton, recent discoveries have shed light on its pivotal role in bone dynamics, with important implications for skeletal health and pathology. However, there are several knowledge gaps and persisting technical limitations that must be addressed to fully unveil the contributions of efferocytosis in bone.
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- Titel
- Efferocytosis and Bone Dynamics
- Verfasst von
-
Lena Batoon
John R. Hawse
Laurie K. McCauley
Megan M. Weivoda
Hernan Roca
- Publikationsdatum
- 24.06.2024
- Verlag
- Springer US
- Erschienen in
-
Current Osteoporosis Reports / Ausgabe 5/2024
Print ISSN: 1544-1873
Elektronische ISSN: 1544-2241 - DOI
- https://doi.org/10.1007/s11914-024-00878-y
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