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Erschienen in: Supportive Care in Cancer 3/2018

01.03.2018 | Original Article

Efficacy and safety of 153Sm-EDTMP as treatment of painful bone metastasis: a large single-center study

verfasst von: Hélène Kolesnikov-Gauthier, Nathalie Lemoine, Emmanuelle Tresch-Bruneel, Anaïs Olivier, Aurore Oudoux, Nicolas Penel

Erschienen in: Supportive Care in Cancer | Ausgabe 3/2018

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Abstract

Purpose

The purpose of this study is to assess the efficacy of 153Sm-EDTMP (Quadramet®) in a clinical setting.

Methods

We have conducted a retrospective study of all consecutive patients (pts) treated with 153Sm-EDTMP for painful bone metastases. At each visit (before and after treatment), four parameters were collected: (i) pain assessment according to the 10-step visual analogue scale (VAS), (ii) sleep disturbance related to pain, (iii) dose of analgesic medication, and (iv) answer to the following closed question “Do you think you obtained a benefit from treatment?” Success of treatment was defined by the combination of these four parameters.

Results

Three hundred seventy consecutive 153Sm-EDTMP treatments for painful bone metastases were given. Patients had the following primary tumors: breast carcinoma (153), prostate carcinoma (155), lung carcinoma (27), or other cancers (35). Fifty-eight percent of the patients had received previous external osseous radiotherapy. Ninety-seven percent of the patients were treated with concomitant analgesics and 61% were treated with diphosphonates. A clinical benefit was described in 55.0% of cases at D30. Treatment was more effective in cases of breast and prostate cancers compared with other types of primary cancers. Patients described a benefit at D30 in 62, 58, 6, and 38% of cases of breast, prostate, lung, and other cancers. The subjective efficacy was accompanied by a decrease in analgesic intake in 35.0% of cases.

Conclusion

153Sm-EDTMP therapy is an effective supportive treatment in patients who suffer from bone metastases, especially in patients with breast or prostate cancer.
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Metadaten
Titel
Efficacy and safety of 153Sm-EDTMP as treatment of painful bone metastasis: a large single-center study
verfasst von
Hélène Kolesnikov-Gauthier
Nathalie Lemoine
Emmanuelle Tresch-Bruneel
Anaïs Olivier
Aurore Oudoux
Nicolas Penel
Publikationsdatum
01.03.2018
Verlag
Springer Berlin Heidelberg
Erschienen in
Supportive Care in Cancer / Ausgabe 3/2018
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-017-3885-3

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