Efficacy and Safety of ARB-Based Combination Therapies for Treatment of Hypertension: A Systematic Review and Meta-analyses
- 16.01.2026
- Review article
- Verfasst von
- Ranu Oza
- Pravesh Aggarwal
- Pankaj Bhardwaj
- Rimple Jeet Kaur
- Deepak Kumar
- Akhil Dhanesh Goel
- Dharamveer Yadav
- Manoj Gupta
- Nitin Joshi
- Chandra Prabha
- Jaykaran Charan
- Erschienen in
- High Blood Pressure & Cardiovascular Prevention
Abstract
Introduction
Hypertension is leading non communicable disease associated with high morbidity and mortality. There is uncertainty about the superiority of angiotensin receptor blocker (ARB)–diuretic versus ARB–calcium channel blocker (CCB) combination for the treatment of hypertension.
Aim
This meta-analysis compares the effectiveness of angiotensin receptor blocker (ARB)–diuretic versus ARB–calcium channel blocker (CCB) combination therapies in adults with hypertension.
Methods
RCTs were identified through PubMed, Embase, Scopus, and Cochrane Central; data were analyzed using RevMan 5.4.1 with a random-effects model. Primary outcomes were mortality, systolic blood pressure (SBP), and diastolic blood pressure (DBP); secondary outcomes included serum electrolytes and renal function.
Results
3549 studies were identified based on database searches. 19 studies were included for analyses. Meta-analysis revealed no significant difference between both the combination therapies for primary outcomes: all-cause mortality [RR: 1.19 (95% CI: 0.85 to 1.65; p = 0.31)], SBP [MD: 1.24 mmHg (95% CI: − 0.48 to 2.96; p = 0.16; I² = 59%)], and DBP [MD: 0.62 mmHg (95% CI: − 0.15 to 1.38; p = 0.11; I² = 0%)]. The diuretic group showed significant changes in serum sodium, chloride, creatinine, e-GFR, and increased uric acid. Risk of bias was mostly low, with moderate to high evidence certainty.
Conclusion
Both ARB + CCB and ARB + diuretic combinations showed comparable effectiveness in lowering blood pressure and all-cause mortality in hypertensive adults. ARB + CCB seems to be having good safety profile, with better renal functions based on biomarkers.
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- Titel
- Efficacy and Safety of ARB-Based Combination Therapies for Treatment of Hypertension: A Systematic Review and Meta-analyses
- Verfasst von
-
Ranu Oza
Pravesh Aggarwal
Pankaj Bhardwaj
Rimple Jeet Kaur
Deepak Kumar
Akhil Dhanesh Goel
Dharamveer Yadav
Manoj Gupta
Nitin Joshi
Chandra Prabha
Jaykaran Charan
- Publikationsdatum
- 16.01.2026
- Verlag
- Springer International Publishing
- Erschienen in
-
High Blood Pressure & Cardiovascular Prevention
Print ISSN: 1120-9879
Elektronische ISSN: 1179-1985 - DOI
- https://doi.org/10.1007/s40292-025-00769-y
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