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Erschienen in: International Ophthalmology 5/2018

12.09.2017 | Original Paper

Efficacy and safety of extemporaneously prepared miconazole eye drops in Candida albicans-induced keratomycosis

verfasst von: Linda Gyanfosu, George Asumeng Koffuor, Samuel Kyei, Ben Ababio-Danso, Kwabena Peprah-Donkor, Wilson Bright Nyansah, Frederick Asare

Erschienen in: International Ophthalmology | Ausgabe 5/2018

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Abstract

Purpose

Extemporaneously prepared miconazole eye drops (EPMD) are used by some eye care practitioners to manage keratomycosis in Ghana. This study therefore aimed to determine the efficacy and safety of EPMD using in vitro and in vivo experimental models.

Methods

The minimum inhibitory concentration (MIC) of EPMD was determined by the agar-well diffusion method. In vivo, the activity of EPMD on corneal ulcer, neovascularization, clouding, edema, carring and on keratomycotic conjunctivitis and corneal scarring (clinical features) associated with Candida albicans-induced keratomycosis in rabbits was determined by treating them with 0.034–1.08% (weight-in-volume) EPMD for a period of 30 days. The safety of EPMD on the healthy eye was determined by instilling various concentrations into the intact eye of the rabbits.

Results

The MIC of EPMD on Candida albicans was 1.08% (zone of inhibition of 13 mm ± 0.578), which resulted in significantly better improvements (p ≤ 0.001) in clinical findings than eyes treated with sterile water (p > 0.05), and showed no significant difference (p > 0.05) compared to eyes treated with 0.3% fluconazole. There were no visible signs of ocular toxicity on instilling it into healthy eyes of rabbits.

Conclusion

The extemporaneously prepared miconazole eye drops are effective and safe to use in keratomycosis.
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Metadaten
Titel
Efficacy and safety of extemporaneously prepared miconazole eye drops in Candida albicans-induced keratomycosis
verfasst von
Linda Gyanfosu
George Asumeng Koffuor
Samuel Kyei
Ben Ababio-Danso
Kwabena Peprah-Donkor
Wilson Bright Nyansah
Frederick Asare
Publikationsdatum
12.09.2017
Verlag
Springer Netherlands
Erschienen in
International Ophthalmology / Ausgabe 5/2018
Print ISSN: 0165-5701
Elektronische ISSN: 1573-2630
DOI
https://doi.org/10.1007/s10792-017-0707-z

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