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Erschienen in: Journal of Neuro-Oncology 2/2018

25.11.2017 | Clinical Study

Efficacy and safety of Levetiracetam vs. other antiepileptic drugs in Hispanic patients with glioblastoma

verfasst von: Andrés F. Cardona, Leonardo Rojas, Beatriz Wills, Laura Bernal, Alejandro Ruiz-Patiño, Oscar Arrieta, Enrique Jiménez Hakim, Fernando Hakim, Juan Armando Mejía, Nicolás Useche, Sonia Bermúdez, Hernán Carranza, Carlos Vargas, Jorge Otero, Luis Carlos Mayor, León Darío Ortíz, Sandra Franco, Carlos Ortíz, Miguel Gil-Gil, Carmen Balaña, Zyanya Lucia Zatarain-Barrón

Erschienen in: Journal of Neuro-Oncology | Ausgabe 2/2018

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Abstract

Epilepsy is a common symptom in patients with glioblastoma (GB). 213 patients with GB from RedLANO follow-up registry were included. All patients underwent surgery, if feasible, followed by chemoradiation based on temozolomide (Stupp platform). Information was recorded regarding demographics, seizure timing, anti-epileptic drugs (AEDs), dosage, time to next seizure, total seizures in 6 months, and main side effects of AEDs. The relationship between epilepsy treatment and overall survival (OS) was evaluated. Mean age was 53 years old and 56.8% were male. Seventy-eight patients (37%) were treated with levetiracetam (LEV), 27% were given another AED and 36% did not require any AED. Choice of AED was not associated with age (p = 0.67), performance status (p = 0.24) or anatomic tumor site (p = 0.34). Seizures and AED requirement were greater in those having primary GB (p = 0.04). After starting an AED, the mean time until next crisis was 9.9 days (SD ± 6.3), which was shorter in those receiving LEV (p = 0.03); mean number of seizures during the first 3 and 6 months were 2.9 and 4, respectively. Most patients treated with LEV (n = 46) required less than two medication adjustments compared to those treated with other AEDs (p = 0.02). Likewise, less patients exposed to LEV required a coadjuvant drug (p = 0.04). Additionally, patients receiving LEV had significantly less adverse effects compared to patients treated with another AED. OS was significantly higher in the group treated with LEV compared to other AEDs (25.5 vs. 17.9 months; p = 0.047). Patients treated with LEV had better seizure control and longer OS compared to other AEDs.
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Metadaten
Titel
Efficacy and safety of Levetiracetam vs. other antiepileptic drugs in Hispanic patients with glioblastoma
verfasst von
Andrés F. Cardona
Leonardo Rojas
Beatriz Wills
Laura Bernal
Alejandro Ruiz-Patiño
Oscar Arrieta
Enrique Jiménez Hakim
Fernando Hakim
Juan Armando Mejía
Nicolás Useche
Sonia Bermúdez
Hernán Carranza
Carlos Vargas
Jorge Otero
Luis Carlos Mayor
León Darío Ortíz
Sandra Franco
Carlos Ortíz
Miguel Gil-Gil
Carmen Balaña
Zyanya Lucia Zatarain-Barrón
Publikationsdatum
25.11.2017
Verlag
Springer US
Erschienen in
Journal of Neuro-Oncology / Ausgabe 2/2018
Print ISSN: 0167-594X
Elektronische ISSN: 1573-7373
DOI
https://doi.org/10.1007/s11060-017-2660-0

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