nach oben

Erschienen in:

08.06.2018 | Original Article

Efficacy and safety of mesenchymal stromal cells for the prophylaxis of chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation: a meta-analysis of randomized controlled trials

verfasst von: Li Wang, Cheng-ying Zhu, De-xun Ma, Zhen-yang Gu, Chang-chun Xu, Fei-yan Wang, Ji-gang Chen, Cheng-jun Liu, Li-xun Guan, Rui Gao, Zhe Gao, Shu Fang, Du-jun Zhuo, Shu-feng Liu, Chun-ji Gao

Erschienen in: Annals of Hematology | Ausgabe 10/2018

Einloggen, um Zugang zu erhalten

Abstract

A meta-analysis of randomized controlled trials (RCTs) was conducted to evaluate the efficacy and safety of mesenchymal stromal cells (MSCs) for the prophylaxis of chronic graft-versus-host disease (cGVHD) in patients with hematological malignancies undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). Six studies involving 365 patients were included. The pooled results showed that MSCs significantly reduced the incidence of cGVHD (risk ratio [RR] 0.63, 95% confidence interval [CI] 0.46 to 0.86, P = 0.004). Favorable prophylactic effects of MSCs on cGVHD were observed with umbilical cord-derived, high-dose, and late-infusion MSCs, while bone marrow-derived, low-dose, and coinfused MSCs did not confer beneficial prophylactic effects. In addition, MSC infusion did not increase the risk of primary disease relapse and infection (RR 1.02, 95% CI 0.70 to 1.50, P = 0.913; RR 0.89, 95% CI 0.44 to 1.81, P = 0.752; respectively). Moreover, there was an apparent trend toward increased overall survival (OS) in the MSC group compared with that in the control group (RR 1.13, 95% CI 0.98 to 1.29, P = 0.084). In conclusion, this meta-analysis demonstrated that MSC infusion is an effective and safe prophylactic strategy for cGVHD in patients with hematological malignancies undergoing allo-HSCT.

Nur mit Berechtigung zugänglich

Copelan EA (2006) Hematopoietic stem-cell transplantation. N Engl J Med 354(17):1813–1826. https://doi.org/10.1056/NEJMra052638 CrossRefPubMed

Socié G, Ritz J (2014) Current issues in chronic graft-versus-host disease. Blood 124(3):374–384. https://doi.org/10.1182/blood-2014-01-514752 CrossRefPubMedPubMedCentral

Kurosawa S, Oshima K, Yamaguchi T, Yanagisawa A, Fukuda T, Kanamori H, Mori T, Takahashi S, Kondo T, Kohno A, Miyamura K, Umemoto Y, Teshima T, Taniguchi S, Yamashita T, Inamoto Y, Kanda Y, Okamoto S, Atsuta Y (2017) Quality of life after allogeneic hematopoietic cell transplantation according to affected organ and severity of chronic graft-versus-host disease. Biol Blood Marrow Transplant 23(10):1749–1758. https://doi.org/10.1016/j.bbmt.2017.06.011 CrossRefPubMed

Sun CL, Kersey JH, Francisco L, Armenian SH, Baker KS, Weisdorf DJ, Forman SJ, Bhatia S (2013) Burden of morbidity in 10+ year survivors of hematopoietic cell transplantation: report from the bone marrow transplantation survivor study. Biol Blood Marrow Transplant 19(7):1073–1080. https://doi.org/10.1016/j.bbmt.2013.04.002 CrossRefPubMedPubMedCentral

Krampera M, Glennie S, Dyson J, Scott D, Laylor R, Simpson E, Dazzi F (2003) Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide. Blood 101(9):3722–3729. https://doi.org/10.1182/blood-2002-07-2104 CrossRefPubMed

Pradier A, Passweg J, Villard J, Kindler V (2011) Human bone marrow stromal cells and skin fibroblasts inhibit natural killer cell proliferation and cytotoxic activity. Cell Transplant 20(5):681–691. https://doi.org/10.3727/096368910x536545 CrossRefPubMed

Corcione A, Benvenuto F, Ferretti E, Giunti D, Cappiello V, Cazzanti F, Risso M, Gualandi F, Mancardi GL, Pistoia V, Uccelli A (2006) Human mesenchymal stem cells modulate B-cell functions. Blood 107(1):367–372. https://doi.org/10.1182/blood-2005-07-2657 CrossRefPubMed

Zhang W, Ge W, Li C, You S, Liao L, Han Q, Deng W, Zhao RC (2004) Effects of mesenchymal stem cells on differentiation, maturation, and function of human monocyte-derived dendritic cells. Stem Cells Dev 13(3):263–271. https://doi.org/10.1089/154732804323099190 CrossRefPubMed

Gao L, Zhang Y, Hu B, Liu J, Kong P, Lou S, Su Y, Yang T, Li H, Liu Y, Zhang C, Gao L, Zhu L, Wen Q, Wang P, Chen X, Zhong J, Zhang X (2016) Phase II multicenter, randomized, double-blind controlled study of efficacy and safety of umbilical cord-derived mesenchymal stromal cells in the prophylaxis of chronic graft-versus-host disease after HLA-haploidentical stem-cell transplantation. J Clin Oncol 34(24):2843–2850. https://doi.org/10.1200/jco.2015.65.3642 CrossRefPubMed

10.

Le Blanc K, Mougiakakos D (2012) Multipotent mesenchymal stromal cells and the innate immune system. Nat Rev Immunol 12(5):383–396. https://doi.org/10.1038/nri3209 CrossRefPubMed

11.

Le Blanc K, Frassoni F, Ball L, Locatelli F, Roelofs H, Lewis I, Lanino E, Sundberg B, Bernardo ME, Remberger M, Dini G, Egeler RM, Bacigalupo A, Fibbe W, Ringden O (2008) Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study. Lancet 371(9624):1579–1586. https://doi.org/10.1016/s0140-6736(08)60690-x CrossRefPubMed

12.

Ringdén O, Uzunel M, Rasmusson I, Remberger M, Sundberg B, Lönnies H, Marschall HU, Dlugosz A, Szakos A, Hassan Z, Omazic B, Aschan J, Barkholt L, Le Blanc K (2006) Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease. Transplantation 81(10):1390–1397. https://doi.org/10.1097/01.tp.0000214462.63943.14 CrossRefPubMed

13.

Kebriaei P, Isola L, Bahceci E, Holland K, Rowley S, McGuirk J, Devetten M, Jansen J, Herzig R, Schuster M, Monroy R, Uberti J (2009) Adult human mesenchymal stem cells added to corticosteroid therapy for the treatment of acute graft-versus-host disease. Biol Blood Marrow Transplant 15(7):804–811. https://doi.org/10.1016/j.bbmt.2008.03.012 CrossRefPubMed

14.

Prasad VK, Lucas KG, Kleiner GI, Talano JA, Jacobsohn D, Broadwater G, Monroy R, Kurtzberg J (2011) Efficacy and safety of ex vivo cultured adult human mesenchymal stem cells (Prochymal) in pediatric patients with severe refractory acute graft-versus-host disease in a compassionate use study. Biol Blood Marrow Transplant 17(4):534–541. https://doi.org/10.1016/j.bbmt.2010.04.014 CrossRefPubMed

15.

Weng JY, Du X, Geng SX, Peng YW, Wang Z, Lu ZS, Wu SJ, Luo CW, Guo R, Ling W, Deng CX, Liao PJ, Xiang AP (2010) Mesenchymal stem cell as salvage treatment for refractory chronic GVHD. Bone Marrow Transplant 45(12):1732–1740. https://doi.org/10.1038/bmt.2010.195 CrossRefPubMedPubMedCentral

16.

Zhou H, Guo M, Bian C, Sun Z, Yang Z, Zeng Y, Ai H, Zhao RC (2010) Efficacy of bone marrow-derived mesenchymal stem cells in the treatment of sclerodermatous chronic graft-versus-host disease: clinical report. Biol Blood Marrow Transplant 16(3):403–412. https://doi.org/10.1016/j.bbmt.2009.11.006 CrossRefPubMed

17.

Lee SH, Lee MW, Yoo KH, Kim DS, Son MH, Sung KW, Cheuh H, Choi SJ, Oh W, Yang YS, Koo HH (2013) Co-transplantation of third-party umbilical cord blood-derived MSCs promotes engraftment in children undergoing unrelated umbilical cord blood transplantation. Bone Marrow Transplant 48(8):1040–1045. https://doi.org/10.1038/bmt.2013.7 CrossRefPubMed

18.

Bernardo ME, Ball LM, Cometa AM, Roelofs H, Zecca M, Avanzini MA, Bertaina A, Vinti L, Lankester A, Maccario R, Ringden O, Le Blanc K, Egeler RM, Fibbe WE, Locatelli F (2011) Co-infusion of ex vivo-expanded, parental MSCs prevents life-threatening acute GVHD, but does not reduce the risk of graft failure in pediatric patients undergoing allogeneic umbilical cord blood transplantation. Bone Marrow Transplant 46(2):200–207. https://doi.org/10.1038/bmt.2010.87 CrossRefPubMed

19.

Kuzmina LA, Petinati NA, Parovichnikova EN, Lubimova LS, Gribanova EO, Gaponova TV, Shipounova IN, Zhironkina OA, Bigildeev AE, Svinareva DA, Drize NJ, Savchenko VG (2012) Multipotent mesenchymal stromal cells for the prophylaxis of acute graft-versus-host disease—a phase II study. Stem Cells Int 2012:968213. https://doi.org/10.1155/2012/968213 CrossRefPubMed

20.

Nauta AJ, Fibbe WE (2007) Immunomodulatory properties of mesenchymal stromal cells. Blood 110(10):3499–3506. https://doi.org/10.1182/blood-2007-02-069716 CrossRefPubMed

21.

Vianello F, Dazzi F (2008) Mesenchymal stem cells for graft-versus-host disease: a double edged sword? Leukemia 22(3):463–465. https://doi.org/10.1038/leu.2008.25 CrossRefPubMed

22.

von Bahr L, Sundberg B, Lonnies L, Sander B, Karbach H, Hagglund H, Ljungman P, Gustafsson B, Karlsson H, Le Blanc K, Ringden O (2012) Long-term complications, immunologic effects, and role of passage for outcome in mesenchymal stromal cell therapy. Biol Blood Marrow Transplant 18(4):557–564. https://doi.org/10.1016/j.bbmt.2011.07.023 CrossRef

23.

Higgins JP, Altman DG, Gotzsche PC, Juni P, Moher D, Oxman AD, Savovic J, Schulz KF, Weeks L, Sterne JA (2011) The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ 343:d5928. https://doi.org/10.1136/bmj.d5928 CrossRefPubMedPubMedCentral

24.

Higgins JP, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21(11):1539–1558. https://doi.org/10.1002/sim.1186 CrossRefPubMed

25.

DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7(3):177–188CrossRefPubMed

26.

Xiang JF (2017) Effect of human umbilical cord mesenchymal stem cells on immune reconstruction of acute lymphoblastic leukemia children undergoing allogeneic hematopoietic stem cell transplantation. Chinese Journal of Tissue Engineering Research 21(29):4679–4684. https://doi.org/10.3969/j.issn.2095-4344.2017.29.015 CrossRef

27.

Wu KH, Tsai C, Wu HP, Sieber M, Peng CT, Chao YH (2013) Human application of ex vivo expanded umbilical cord-derived mesenchymal stem cells: enhance hematopoiesis after cord blood transplantation. Cell Transplant 22(11):2041–2051. https://doi.org/10.3727/096368912X663533 CrossRefPubMed

28.

Shipounova IN, Petinati NA, Bigildeev AE, Zezina EA, Drize NI, Kuzmina LA, Parovichnikova EN, Savchenko VG (2014) Analysis of results of acute graft-versus-host disease prophylaxis with donor multipotent mesenchymal stromal cells in patients with hemoblastoses after allogeneic bone marrow transplantation. Biochemistry (Mosc) 79(12):1363–1370. https://doi.org/10.1134/s0006297914120104 CrossRef

29.

Ning H, Yang F, Jiang M, Hu L, Feng K, Zhang J, Yu Z, Li B, Xu C, Li Y, Wang J, Hu J, Lou X, Chen H (2008) The correlation between cotransplantation of mesenchymal stem cells and higher recurrence rate in hematologic malignancy patients: outcome of a pilot clinical study. Leukemia 22(3):593–599. https://doi.org/10.1038/sj.leu.2405090 CrossRefPubMed

30.

Liu K, Chen Y, Zeng Y, Xu L, Liu D, Chen H, Zhang X, Han W, Wang Y, Zhao T, Wang J, Wang J, Han Q, Zhao C, Huang X (2011) Coinfusion of mesenchymal stromal cells facilitates platelet recovery without increasing leukemia recurrence in haploidentical hematopoietic stem cell transplantation: a randomized, controlled clinical study. Stem Cells Dev 20(10):1679–1685. https://doi.org/10.1089/scd.2010.0447 CrossRefPubMed

31.

Kallekleiv M, Larun L, Bruserud O, Hatfield KJ (2016) Co-transplantation of multipotent mesenchymal stromal cells in allogeneic hematopoietic stem cell transplantation: a systematic review and meta-analysis. Cytotherapy 18(2):172–185. https://doi.org/10.1016/j.jcyt.2015.11.010 CrossRefPubMed

32.

Li H, Jiang Y, Jiang X, Guo X, Ning H, Li Y, Liao L, Yao H, Wang X, Liu Y, Zhang Y, Chen H, Mao N (2014) CCR7 guides migration of mesenchymal stem cell to secondary lymphoid organs: a novel approach to separate GvHD from GvL effect. Stem Cells 32(7):1890–1903. https://doi.org/10.1002/stem.1656 CrossRefPubMed

33.

Karlsson H, Samarasinghe S, Ball LM, Sundberg B, Lankester AC, Dazzi F, Uzunel M, Rao K, Veys P, Le Blanc K, Ringden O, Amrolia PJ (2008) Mesenchymal stem cells exert differential effects on alloantigen and virus-specific T-cell responses. Blood 112(3):532–541. https://doi.org/10.1182/blood-2007-10-119370 CrossRefPubMed

34.

Van Der Wagen L, Te Boome L, Mansilla C, Lindemans C, Cuijpers M, Westinga K, Petersen E, Spierings E, Bierings M, Boelens JJ, Wulffraat N, Slaper-Cortenbach I, Kuball J (2014) Treatment of steroid resistant grade II to IV acute GVHD by infusion of mesenchymal stroma cells expanded with platelet lysate—a phase I/II study. Bone Marrow Transplant 49:S19–S20. https://doi.org/10.1038/bmt.2014.43 CrossRef

35.

Introna M, Lucchini G, Dander E, Galimberti S, Rovelli A, Balduzzi A, Longoni D, Pavan F, Masciocchi F, Algarotti A, Mico C, Grassi A, Deola S, Cavattoni I, Gaipa G, Belotti D, Perseghin P, Parma M, Pogliani E, Golay J, Pedrini O, Capelli C, Cortelazzo S, D'Amico G, Biondi A, Rambaldi A, Biagi E (2014) Treatment of graft versus host disease with mesenchymal stromal cells: a phase I study on 40 adult and pediatric patients. Biol Blood Marrow Transplant 20(3):375–381. https://doi.org/10.1016/j.bbmt.2013.11.033 CrossRefPubMed

36.

Chen X, Wang C, Yin J, Xu J, Wei J, Zhang Y (2015) Efficacy of mesenchymal stem cell therapy for steroid-refractory acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation: a systematic review and meta-analysis. PLoS One 10(8):e0136991. https://doi.org/10.1371/journal.pone.0136991 CrossRefPubMedPubMedCentral

37.

Zhuo Y, Li SH, Chen MS, Wu J, Kinkaid HY, Fazel S, Weisel RD, Li RK (2010) Aging impairs the angiogenic response to ischemic injury and the activity of implanted cells: combined consequences for cell therapy in older recipients. J Thorac Cardiovasc Surg 139(5):1286–1294, 1294.e1281-1282. https://doi.org/10.1016/j.jtcvs.2009.08.052 CrossRefPubMed

38.

Galipeau J (2013) The mesenchymal stromal cells dilemma—does a negative phase III trial of random donor mesenchymal stromal cells in steroid-resistant graft-versus-host disease represent a death knell or a bump in the road? Cytotherapy 15(1):2–8. https://doi.org/10.1016/j.jcyt.2012.10.002 CrossRefPubMed

39.

Wang L, Zhang H, Guan L, Zhao S, Gu Z, Wei H, Gao Z, Wang F, Yang N, Luo L, Li Y, Wang L, Liu D, Gao C (2016) Mesenchymal stem cells provide prophylaxis against acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation: a meta-analysis of animal models. Oncotarget 7(38):61764–61774. https://doi.org/10.18632/oncotarget.11238 CrossRefPubMedPubMedCentral

40.

Wegmeyer H, Broske AM, Leddin M, Kuentzer K, Nisslbeck AK, Hupfeld J, Wiechmann K, Kuhlen J, von Schwerin C, Stein C, Knothe S, Funk J, Huss R, Neubauer M (2013) Mesenchymal stromal cell characteristics vary depending on their origin. Stem Cells Dev 22(19):2606–2618. https://doi.org/10.1089/scd.2013.0016 CrossRefPubMedPubMedCentral

41.

Karlsson H, Erkers T, Nava S, Ruhm S, Westgren M, Ringden O (2012) Stromal cells from term fetal membrane are highly suppressive in allogeneic settings in vitro. Clin Exp Immunol 167(3):543–555. https://doi.org/10.1111/j.1365-2249.2011.04540.x CrossRefPubMedPubMedCentral

42.

Prasanna SJ, Gopalakrishnan D, Shankar SR, Vasandan AB (2010) Pro-inflammatory cytokines, IFNgamma and TNFalpha, influence immune properties of human bone marrow and Wharton jelly mesenchymal stem cells differentially. PLoS One 5(2):e9016. https://doi.org/10.1371/journal.pone.0009016 CrossRefPubMedPubMedCentral

43.

Deuse T, Stubbendorff M, Tang-Quan K, Phillips N, Kay MA, Eiermann T, Phan TT, Volk HD, Reichenspurner H, Robbins RC, Schrepfer S (2011) Immunogenicity and immunomodulatory properties of umbilical cord lining mesenchymal stem cells. Cell Transplant 20(5):655–667. https://doi.org/10.3727/096368910x536473 CrossRefPubMed

44.

Bartholomew A, Sturgeon C, Siatskas M, Ferrer K, McIntosh K, Patil S, Hardy W, Devine S, Ucker D, Deans R, Moseley A, Hoffman R (2002) Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo. Exp Hematol 30(1):42–48CrossRefPubMed

45.

Le Blanc K, Tammik L, Sundberg B, Haynesworth SE, Ringden O (2003) Mesenchymal stem cells inhibit and stimulate mixed lymphocyte cultures and mitogenic responses independently of the major histocompatibility complex. Scand J Immunol 57(1):11–20CrossRefPubMed

46.

Klyushnenkova E, Mosca JD, Zernetkina V, Majumdar MK, Beggs KJ, Simonetti DW, Deans RJ, McIntosh KR (2005) T cell responses to allogeneic human mesenchymal stem cells: immunogenicity, tolerance, and suppression. J Biomed Sci 12(1):47–57. https://doi.org/10.1007/s11373-004-8183-7 CrossRefPubMed

47.

Polchert D, Sobinsky J, Douglas G, Kidd M, Moadsiri A, Reina E, Genrich K, Mehrotra S, Setty S, Smith B, Bartholomew A (2008) IFN-gamma activation of mesenchymal stem cells for treatment and prevention of graft versus host disease. Eur J Immunol 38(6):1745–1755. https://doi.org/10.1002/eji.200738129 CrossRefPubMedPubMedCentral

48.

Tisato V, Naresh K, Girdlestone J, Navarrete C, Dazzi F (2007) Mesenchymal stem cells of cord blood origin are effective at preventing but not treating graft-versus-host disease. Leukemia 21(9):1992–1999. https://doi.org/10.1038/sj.leu.2404847 CrossRefPubMed

49.

Zeiser R, Blazar BR (2016) Preclinical models of acute and chronic graft-versus-host disease: how predictive are they for a successful clinical translation? Blood 127(25):3117–3126. https://doi.org/10.1182/blood-2016-02-699082 CrossRefPubMedPubMedCentral

50.

Markey KA, MacDonald KP, Hill GR (2014) The biology of graft-versus-host disease: experimental systems instructing clinical practice. Blood 124(3):354–362. https://doi.org/10.1182/blood-2014-02-514745 CrossRefPubMedPubMedCentral

51.

Binato R, de Souza Fernandez T, Lazzarotto-Silva C, Du Rocher B, Mencalha A, Pizzatti L, Bouzas LF, Abdelhay E (2013) Stability of human mesenchymal stem cells during in vitro culture: considerations for cell therapy. Cell Prolif 46(1):10–22. https://doi.org/10.1111/cpr.12002 CrossRefPubMed

52.

Samuelsson H, Ringden O, Lonnies H, Le Blanc K (2009) Optimizing in vitro conditions for immunomodulation and expansion of mesenchymal stromal cells. Cytotherapy 11(2):129–136. https://doi.org/10.1080/14653240802684194 CrossRefPubMed

53.

Moll G, Alm JJ, Davies LC, Von Bahr L, Heldring N, Stenbeck-Funke L, Hamad OA, Hinsch R, Ignatowicz L, Locke M, Lönnies H, Lambris JD, Teramura Y, Nilsson-Ekdahl K, Nilsson B, Le Blanc K (2014) Do cryopreserved mesenchymal stromal cells display impaired immunomodulatory and therapeutic properties? Stem Cells 32(9):2430–2442. https://doi.org/10.1002/stem.1729 CrossRefPubMedPubMedCentral

54.

François M, Copland IB, Yuan S, Romieu-Mourez R, Waller EK, Galipeau J (2012) Cryopreserved mesenchymal stromal cells display impaired immunosuppressive properties as a result of heat-shock response and impaired interferon-γ licensing. Cytotherapy 14(2):147–152. https://doi.org/10.3109/14653249.2011.623691 CrossRefPubMed

55.

Luetzkendorf J, Nerger K, Hering J, Moegel A, Hoffmann K, Hoefers C, Mueller-Tidow C, Mueller LP (2015) Cryopreservation does not alter main characteristics of good manufacturing process-grade human multipotent mesenchymal stromal cells including immunomodulating potential and lack of malignant transformation. Cytotherapy 17(2):186–198. https://doi.org/10.1016/j.jcyt.2014.10.018 CrossRefPubMed

56.

de Lima Prata K, de Santis GC, Orellana MD, Palma PV, Brassesco MS, Covas DT (2012) Cryopreservation of umbilical cord mesenchymal cells in xenofree conditions. Cytotherapy 14(6):694–700. https://doi.org/10.3109/14653249.2012.677820 CrossRefPubMed

57.

Valencic E, Piscianz E, Andolina M, Ventura A, Tommasini A (2010) The immunosuppressive effect of Wharton’s jelly stromal cells depends on the timing of their licensing and on lymphocyte activation. Cytotherapy 12(2):154–160. https://doi.org/10.3109/14653240903493417 CrossRefPubMed

58.

Wang L, Gu Z, Zhao X, Yang N, Wang F, Deng A, Zhao S, Luo L, Wei H, Guan L, Gao Z, Li Y, Wang L, Liu D, Gao C (2016) Extracellular vesicles released from human umbilical cord-derived mesenchymal stromal cells prevent life-threatening acute graft-versus-host disease in a mouse model of allogeneic hematopoietic stem cell transplantation. Stem Cells Dev 25(24):1874–1883. https://doi.org/10.1089/scd.2016.0107 CrossRefPubMed

59.

Kordelas L, Rebmann V, Ludwig AK, Radtke S, Ruesing J, Doeppner TR, Epple M, Horn PA, Beelen DW, Giebel B (2014) MSC-derived exosomes: a novel tool to treat therapy-refractory graft-versus-host disease. Leukemia 28(4):970–973. https://doi.org/10.1038/leu.2014.41 CrossRefPubMed

Titel: Efficacy and safety of mesenchymal stromal cells for the prophylaxis of chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation: a meta-analysis of randomized controlled trials
verfasst von: Li Wang
Cheng-ying Zhu
De-xun Ma
Zhen-yang Gu
Chang-chun Xu
Fei-yan Wang
Ji-gang Chen
Cheng-jun Liu
Li-xun Guan
Rui Gao
Zhe Gao
Shu Fang
Du-jun Zhuo
Shu-feng Liu
Chun-ji Gao
Publikationsdatum: 08.06.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Annals of Hematology / Ausgabe 10/2018
Print ISSN: 0939-5555
Elektronische ISSN: 1432-0584
DOI: https://doi.org/10.1007/s00277-018-3384-8

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

23.04.2024 | Ablationstherapie | Nachrichten

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Efficacy and safety of mesenchymal stromal cells for the prophylaxis of chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation: a meta-analysis of randomized controlled trials

Abstract

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Wie erfolgreich ist eine Re-Ablation nach Rezidiv?

Europäische Ernährungsgewohnheiten: Das sind die häufigsten Fehler

Hinter dieser Appendizitis steckte ein Erreger

Demenzkranke durch Antipsychotika vielfach gefährdet

Update Innere Medizin

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 10/2018

Cytogenetic clonal heterogeneity is not an independent prognosis factor in 15–60-year-old AML patients: results on 1291 patients included in the EORTC/GIMEMA AML-10 and AML-12 trials

Monotypic and IgH-rearranged lymphoplasmacytic cells restricted to the light zone of germinal centers: an early (in situ?) marginal zone lymphoma?

Changes in estimated glomerular filtration rate in chronic myeloid leukemia patients treated front line with available TKIs and correlation with cardiovascular events

The effect of desferrioxamine chelation versus no therapy in patients with non transfusion-dependent thalassaemia: a multicenter prospective comparison from the MIOT network

Fludarabine and busulfan plus low-dose TBI as reduced intensity conditioning in older patients undergoing allogeneic hematopoietic cell transplant for myeloid malignancies

Chronic lymphocytic leukemia international prognostic index (CLL-IPI) in patients receiving chemoimmuno or targeted therapy: a systematic review and meta-analysis

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Wie erfolgreich ist eine Re-Ablation nach Rezidiv?

Europäische Ernährungsgewohnheiten: Das sind die häufigsten Fehler

Hinter dieser Appendizitis steckte ein Erreger

Demenzkranke durch Antipsychotika vielfach gefährdet

Update Innere Medizin