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01.12.2012 | Research | Ausgabe 1/2012 Open Access

Malaria Journal 1/2012

Efficacy of artemether-lumefantrine as a treatment for uncomplicated Plasmodium vivax malaria in eastern Sudan

Zeitschrift:
Malaria Journal > Ausgabe 1/2012
Autoren:
Tajeldin M Abdallah, Abdel Aziem A Ali, Mohammed Bakri, Gasim I Gasim, Imad R Musa, Ishag Adam
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1475-2875-11-404) contains supplementary material, which is available to authorized users.

Competing interest

The authors declare that they have no competing interests.

Authors' contributions

TM, GIG, IA designed the study, AAA, IRM and MB conducted the clinical work. All of the authors drafted and approved the manuscript.

Abstract

Background

Artemisinin-based combination therapy (ACT) is the treatment of choice for uncomplicated Plasmodium falciparum malaria in most areas of the world, where malaria is endemic, including Sudan. However, few published data are available on the use of ACT for treatment of P. vivax malaria.

Methods

This study was conducted at a health centre in Kassala, eastern Sudan, from October to December 2011. Patients with uncomplicated P. vivax malaria received artemether-lumefantrine (AL) tablets (containing 20mg artemether and 120 mg lumefantrine) and were monitored for 28 days.

Results

Out of the 43 cases enrolled in this study, 38 completed the 28-day follow-up. Their mean age was 25.1 years (SD: 1.5). On day 3 following AL treatment, all of the patients were afebrile and aparasitaemic. By day 28, all 38 patients exhibited adequate clinical and parasitological responses to AL treatment. The cure rate was 100% and 88.4% for the per protocol analysis andfor the intention to treat analysis, respectively. Mild adverse effects (nausea, vomiting, abdominal pain, dizziness and/or rash) that resolved spontaneously were observed in four (10.5%) of the patients.

Conclusion

AL combination therapy was fully effective for treatment of P. vivax malaria in the study in eastern Sudan.

Trial registration

Trial. Gov: NCT01625871
Zusatzmaterial
Authors’ original file for figure 1
12936_2012_2542_MOESM1_ESM.pdf
Authors’ original file for figure 2
12936_2012_2542_MOESM2_ESM.pdf
Literatur
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