Efficacy of collagenated bone substitutes for bone regeneration in two-wall-damaged extraction sockets without barrier membranes
- 01.04.2025
- Research
Erschienen in:
- Verfasst von
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Seungho Jeong
Seungho Jeong
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Seungho Jeong and Franz J. Strauss contributed equally to this work.
- Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, 03722, Seoul, South Korea
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Franz J. Strauss
Franz J. Strauss
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Seungho Jeong and Franz J. Strauss contributed equally to this work.
- Clinic of Reconstructive Dentistry, Center for Dental Medicine, University of Zurich, Zurich, Switzerland
- Faculty of Health Sciences, Universidad Autonoma de Chile, Temuco, Chile
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Hae Jee Shin
Hae Jee Shin
- Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, 03722, Seoul, South Korea
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Jin-Young Park
Jin-Young Park
- Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, 03722, Seoul, South Korea
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Jae-Kook Cha
Jae-Kook Cha
- Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, 03722, Seoul, South Korea
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Jung-Seok Lee
Korrespondierender Autor Jung-Seok Lee
- Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, 03722, Seoul, South Korea
- Erschienen in
- Clinical Oral Investigations | Ausgabe 4/2025
Abstract
Objectives
To evaluate ridge dimensional changes following alveolar ridge augmentation in two-wall-damaged extraction sockets without a barrier membrane, using two types of collagenated bone substitutes i. cross-linked (CL-CB) and ii. non-cross-linked (NCL-CB).
Materials and methods
Two-wall defects were created in mandibles of seven beagle dogs and treated in three groups: (i) no grafting (control), (ii) sockets filled with NCL-CB, and (iii) sockets filled with CL-CB. No barrier membrane was used. One animal was sacrificed after 1 week of healing for tissue assessments (n = 1), and the other six were sacrificed after 8 weeks of healing for microcomputed tomography (micro-CT) and histological analyses (n = 6).
Results
Compared to unextracted sites, radiographic analysis revealed that the alveolar ridge dimension decreased to 83.29 ± 24.96% in group NCL-CB, 73.46 ± 16.59% in group CL-CB and 55.41 ± 12.95% in non-grafted sites (intergroup p = 0.062). Histological analysis showed that compared to baseline values the ridge area decreased to 68.75 ± 14.20% in the non-grafted group, 79.88 ± 20.05% in the NCL-CB group and 76.10 ± 21.09% in the CL-CB group with no significant differences between the groups (p > 0.05). Qualitative histological analyses revealed significantly less mineralized tissue in both test groups, amounting to 25.28 ± 10.40% in group NCL-CB, 29.86 ± 12.04% in group CL-CB, and 67.15 ± 14.35% in non-grafted sites (intergroup p < 0.05).
Conclusion
The efficacy of alveolar ridge augmentation using either cross-linked or non-cross-linked collagenated bone substitutes alone might be limited in severely damaged sockets such as those with two-wall defects.
Clinical relevance
In situations where sockets are extensively damaged, like those with two-wall defects, relying solely on soft-type bone block substitutes without a barrier membrane may not provide sufficient bone regeneration. This study highlights the importance of considering additional regenerative strategies, such as the use of barrier membranes, to enhance clinical outcomes.
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- Titel
- Efficacy of collagenated bone substitutes for bone regeneration in two-wall-damaged extraction sockets without barrier membranes
- Verfasst von
-
Seungho Jeong
Franz J. Strauss
Hae Jee Shin
Jin-Young Park
Jae-Kook Cha
Jung-Seok Lee
- Publikationsdatum
- 01.04.2025
- Verlag
- Springer Berlin Heidelberg
- Erschienen in
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Clinical Oral Investigations / Ausgabe 4/2025
Print ISSN: 1432-6981
Elektronische ISSN: 1436-3771 - DOI
- https://doi.org/10.1007/s00784-025-06281-w
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