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11.10.2019 | Original Paper | Ausgabe 6/2019

Infection 6/2019

Efficacy of educational intervention on reducing the inappropriate use of oral third-generation cephalosporins

Zeitschrift:
Infection > Ausgabe 6/2019
Autoren:
Atsushi Uda, Takeshi Kimura, Sho Nishimura, Kei Ebisawa, Goh Ohji, Mari Kusuki, Mariko Yahata, Rie Izuta, Tomoyuki Sakaue, Tatsuya Nakamura, Chihiro Koike, Issei Tokimatsu, Ikuko Yano, Kentaro Iwata, Takayuki Miyara
Wichtige Hinweise
Atsushi Uda and Takeshi Kimura contributed equally to this work.

Abstract

Purpose

This study aimed to evaluate the efficacy of an educational intervention on reducing the inappropriate use of oral third-generation cephalosporins, the prevalence of resistant bacteria, and clinical outcomes.

Methods

A before-after study was conducted to compare the data for 1 year before and after intervention at a Japanese university hospital. Educational intervention included lectures for all medical staff on oral antibiotics and educational meetings with each medical department. The primary outcome was the use of oral third-generation cephalosporins in inpatients as measured by the monthly median days of therapy (DOTs) per 1000 patient days. Secondary outcomes included the use of each oral antibiotic in inpatients and outpatients, proportion of β-lactamase-nonproducing ampicillin-resistant Haemophilus influenzae (BLNAR), penicillin-resistant Streptococcus pneumoniae (PRSP) and extended-spectrum β-lactamase producing Escherichia coli (ESBLEC), the incidence of hospital-acquired Clostridioides difficile infection (HA-CDI), and hospital mortality.

Results

The use of oral third-generation cephalosporins in inpatients was significantly decreased after intervention [DOTs (interquartile range): 24.2 (23.5–25.1) vs. 3.7 (0.0–7.1), P < 0.001], and the value in outpatients was also decreased significantly. The use of fluoroquinolones and macrolides did not increase after intervention. The proportion of BLNAR, PRSP and ESBLEC did not change significantly during the study period. The incidence of HA-CDI was significantly decreased, and hospital mortality did not change after intervention.

Conclusion

Educational intervention was effective in reducing the use of oral third-generation cephalosporins without increasing the use of broad-spectrum antibiotics and worsening clinical outcome. The prevalence of resistant bacteria did not change during the study period.

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