Skip to main content
Erschienen in: Lasers in Medical Science 1/2019

11.07.2018 | Original Article

Efficacy of Nd-YAG laser for treatment of pyogenic granuloma on the fingers and toes

verfasst von: J. Dong, S. G. Peng, X. Y. Zhang, C. G. Tong, F. Liu, M. Cao, Y. H. Li, Y. L. He

Erschienen in: Lasers in Medical Science | Ausgabe 1/2019

Einloggen, um Zugang zu erhalten

Abstract

Pyogenic granuloma (PG) is a common benign vascular proliferation which often occurs on the head, neck, hands, and feet. Among the various treatment options for PG, surgical excision is the most effective treatment which offers the lowest overall recurrence rates and also provides the exact diagnosis. However, it could have difficulties to do the surgery when lesions are located on the fingers and toes, especially very near to the nails, so laser may be a very good alternative choice. In this article, we evaluated the clinical efficacy and safety of neodymium-yttrium aluminum garnet (Nd:YAG) laser for treatment of PG located on the fingers and toes. Twenty-one patients with 21 PGs located on the fingers and toes were treated by multispot Nd-YAG laser. We chose monopulse (pulse width 10.5–13.5 ms; energy 100–125 J/cm2); treatment interval was 3–4 weeks. All lesions disappeared after one or two treatments. There was no apparent scar formation, no impact on the function of the fingers and toes, no damage to nail growth, and no recurrence in more than 12-month follow-up. Nd-YAG is an effective and safety treatment option for treatment of PG located on the fingers and toes.
Literatur
1.
Zurück zum Zitat Harris MN, Desai R, Chuang TY, Hood AF, Mirowski GW (2000) Lobular capillary hemangiomas: an epidemiologic report, with emphasis on cutaneous lesions. J Am Acad Dermatol 42(6):1012–1016CrossRefPubMed Harris MN, Desai R, Chuang TY, Hood AF, Mirowski GW (2000) Lobular capillary hemangiomas: an epidemiologic report, with emphasis on cutaneous lesions. J Am Acad Dermatol 42(6):1012–1016CrossRefPubMed
2.
Zurück zum Zitat Patrice SJ, Wiss K, Mulliken JB (1991) Pyogenic granuloma (lobular capillary hemangioma): a clinicopathologic study of 178 cases. Pediatr Dermatol 8(4):267–276CrossRefPubMed Patrice SJ, Wiss K, Mulliken JB (1991) Pyogenic granuloma (lobular capillary hemangioma): a clinicopathologic study of 178 cases. Pediatr Dermatol 8(4):267–276CrossRefPubMed
3.
Zurück zum Zitat Akamatsu T, Hanai U, Kobayashi M, Miyasaka M. Pyogenic granuloma: a retrospective 10-year analysis of 82 cases. Tokai J Exp Clin Med 2015; 20; 40(3):110–4 Akamatsu T, Hanai U, Kobayashi M, Miyasaka M. Pyogenic granuloma: a retrospective 10-year analysis of 82 cases. Tokai J Exp Clin Med 2015; 20; 40(3):110–4
4.
5.
Zurück zum Zitat Lee J, Sinno H, Tahiri Y, Gilardino MS (2011) Treatment options for cutaneous pyogenic granulomas: a review. J Plast Reconstr Aesthet Surg 64(9):1216–1220CrossRefPubMed Lee J, Sinno H, Tahiri Y, Gilardino MS (2011) Treatment options for cutaneous pyogenic granulomas: a review. J Plast Reconstr Aesthet Surg 64(9):1216–1220CrossRefPubMed
6.
Zurück zum Zitat Fekrazad R, Nokhbatolfoghahaei H, Khoei F, Kalhori KA (2014) Pyogenic granuloma: surgical treatment with Er:YAG laser. J Lasers Med Sci 5(4):199–205PubMedPubMedCentral Fekrazad R, Nokhbatolfoghahaei H, Khoei F, Kalhori KA (2014) Pyogenic granuloma: surgical treatment with Er:YAG laser. J Lasers Med Sci 5(4):199–205PubMedPubMedCentral
7.
Zurück zum Zitat Hasanoglu Erbasar GN, Senguven B, Gultekin SE, Cetiner S (2016) Management of a recurrent pyogenic granuloma of the hard palate with diode laser: a case report. J Lasers Med Sci 7(1):56–61CrossRefPubMedPubMedCentral Hasanoglu Erbasar GN, Senguven B, Gultekin SE, Cetiner S (2016) Management of a recurrent pyogenic granuloma of the hard palate with diode laser: a case report. J Lasers Med Sci 7(1):56–61CrossRefPubMedPubMedCentral
8.
9.
Zurück zum Zitat Gupta D, Singh N, Thappa DM (2016) Is timolol an effective treatment for pyogenic granuloma? Int J Dermatol 55(5):592–595CrossRef Gupta D, Singh N, Thappa DM (2016) Is timolol an effective treatment for pyogenic granuloma? Int J Dermatol 55(5):592–595CrossRef
10.
Zurück zum Zitat Chiriac A, Birsan C, Podoleanu C, Moldovan C, Brzezinski P, Stolnicu S (2016) Noninvasive treatment of pyogenic granulomas in young children with topical timolol and trichloroacetic acid. J Pediatr 169:322–322CrossRefPubMed Chiriac A, Birsan C, Podoleanu C, Moldovan C, Brzezinski P, Stolnicu S (2016) Noninvasive treatment of pyogenic granulomas in young children with topical timolol and trichloroacetic acid. J Pediatr 169:322–322CrossRefPubMed
11.
Zurück zum Zitat Piraccini BM, Alessandrini A, Dika E, Starace M, Patrizi A, Neri I (2016) Topical propranolol 1% cream for pyogenic granulomas of the nail: open-label study in 10 patients. J Eur Acad Dermatol Venereol 30(5):901–902CrossRef Piraccini BM, Alessandrini A, Dika E, Starace M, Patrizi A, Neri I (2016) Topical propranolol 1% cream for pyogenic granulomas of the nail: open-label study in 10 patients. J Eur Acad Dermatol Venereol 30(5):901–902CrossRef
12.
Zurück zum Zitat Liu J, Zhou BR, Yi F, Wu HJ, Zhang JA, Luo D (2016) Pyogenic granuloma in a patient with psoriasis successfully treated by 5 aminolevulinic acid photodynamic therapy: a case report. Exp Ther Med 11(1):345–347CrossRefPubMed Liu J, Zhou BR, Yi F, Wu HJ, Zhang JA, Luo D (2016) Pyogenic granuloma in a patient with psoriasis successfully treated by 5 aminolevulinic acid photodynamic therapy: a case report. Exp Ther Med 11(1):345–347CrossRefPubMed
13.
Zurück zum Zitat Malvehy J, Puig S, Argenziano G, Marghoob AA, Soyer HP, International Dermoscopy Society Board members (2007) Dermoscopy report: proposal for standardization. Results of a consensus meeting of the International Dermoscopy Society. J Am Acad Dermatol 57(1):84–95CrossRefPubMed Malvehy J, Puig S, Argenziano G, Marghoob AA, Soyer HP, International Dermoscopy Society Board members (2007) Dermoscopy report: proposal for standardization. Results of a consensus meeting of the International Dermoscopy Society. J Am Acad Dermatol 57(1):84–95CrossRefPubMed
14.
Zurück zum Zitat Zaballos P, Carulla M, Ozdemir F, Zalaudek I, Bañuls J, Llambrich A, Puig S, Argenziano G, Malvehy J (2010) Dermoscopy of pyogenic granuloma: a morphological study. Br J Dermatol 163(6):1229–1237CrossRefPubMed Zaballos P, Carulla M, Ozdemir F, Zalaudek I, Bañuls J, Llambrich A, Puig S, Argenziano G, Malvehy J (2010) Dermoscopy of pyogenic granuloma: a morphological study. Br J Dermatol 163(6):1229–1237CrossRefPubMed
15.
Zurück zum Zitat Grazzini M, Stanganelli I, Rossari S, Gori A, Oranges T, Longo AS, Lotti T, Bencini PL, De Giorgi V (2012) Dermoscopy, confocal laser microscopy, and hi-tech evaluation of vascular skin lesions: diagnostic and therapeutic perspectives. Dermatol Ther 25(4):297–303CrossRefPubMed Grazzini M, Stanganelli I, Rossari S, Gori A, Oranges T, Longo AS, Lotti T, Bencini PL, De Giorgi V (2012) Dermoscopy, confocal laser microscopy, and hi-tech evaluation of vascular skin lesions: diagnostic and therapeutic perspectives. Dermatol Ther 25(4):297–303CrossRefPubMed
16.
Zurück zum Zitat Godfraind C, Calicchio ML, Kozakewich H (2013) Pyogenic granuloma, an impaired wound healing process, linked to vascular growth driven by FLT4 and the nitric oxide pathway. Mod Pathol 26(2):247–255CrossRefPubMed Godfraind C, Calicchio ML, Kozakewich H (2013) Pyogenic granuloma, an impaired wound healing process, linked to vascular growth driven by FLT4 and the nitric oxide pathway. Mod Pathol 26(2):247–255CrossRefPubMed
17.
Zurück zum Zitat Lin RL, Janniger CK (2004) Pyogenic granuloma. Cutis 74(4):229–233PubMed Lin RL, Janniger CK (2004) Pyogenic granuloma. Cutis 74(4):229–233PubMed
18.
Zurück zum Zitat Lim YH, Douglas SR, Ko CJ, Antaya RJ, Mcniff JM, Zhou J, Choate KA, Narayan D (2015) Somatic activating RAS mutations cause vascular tumors including pyogenic granuloma. J Invest Dermatol 135(6):1698–1700CrossRefPubMedPubMedCentral Lim YH, Douglas SR, Ko CJ, Antaya RJ, Mcniff JM, Zhou J, Choate KA, Narayan D (2015) Somatic activating RAS mutations cause vascular tumors including pyogenic granuloma. J Invest Dermatol 135(6):1698–1700CrossRefPubMedPubMedCentral
19.
Zurück zum Zitat Groesser L, Peterhof E, Evert M, Landthaler M, Berneburg M, Hafner C (2016) BRAF and RAS mutations in sporadic and secondary pyogenic granuloma. J Invest Dermatol 136(2):481–486CrossRefPubMed Groesser L, Peterhof E, Evert M, Landthaler M, Berneburg M, Hafner C (2016) BRAF and RAS mutations in sporadic and secondary pyogenic granuloma. J Invest Dermatol 136(2):481–486CrossRefPubMed
20.
Zurück zum Zitat Marla V, Shrestha A, Goel K, Shrestha S (2016) The histopathological spectrum of pyogenic granuloma: a case series. Case Rep Dent 2016:1323798PubMedPubMedCentral Marla V, Shrestha A, Goel K, Shrestha S (2016) The histopathological spectrum of pyogenic granuloma: a case series. Case Rep Dent 2016:1323798PubMedPubMedCentral
21.
Zurück zum Zitat Goldberg DJ, Sciales CW (1991) Pyogenic granuloma in children: treatment with the flashlamp-pumped pulsed dye laser. J Dermatol Surg Oncol 17(12):960–962CrossRefPubMed Goldberg DJ, Sciales CW (1991) Pyogenic granuloma in children: treatment with the flashlamp-pumped pulsed dye laser. J Dermatol Surg Oncol 17(12):960–962CrossRefPubMed
22.
Zurück zum Zitat Glass AT, Milgraum S (1992) Flashlamp-pumped pulsed dye laser treatment for pyogenic granuloma. Cutis 49(5):351–353PubMed Glass AT, Milgraum S (1992) Flashlamp-pumped pulsed dye laser treatment for pyogenic granuloma. Cutis 49(5):351–353PubMed
23.
Zurück zum Zitat González S, Vibhagool C, Falo LD Jr, Momtaz KT, Grevelink J, González E (1996) Treatment of pyogenic granulomas with the 585 nm pulsed dye laser. J Am Acad Dermatol 35(3 Pt 1):428–431CrossRefPubMed González S, Vibhagool C, Falo LD Jr, Momtaz KT, Grevelink J, González E (1996) Treatment of pyogenic granulomas with the 585 nm pulsed dye laser. J Am Acad Dermatol 35(3 Pt 1):428–431CrossRefPubMed
24.
Zurück zum Zitat Miller PK, Levitt J (2011) Treatment of multiple periungual pyogenic granulomata from pincer nails with pulsed dye laser. Dermatol Surg 37(8):1176–1179CrossRefPubMed Miller PK, Levitt J (2011) Treatment of multiple periungual pyogenic granulomata from pincer nails with pulsed dye laser. Dermatol Surg 37(8):1176–1179CrossRefPubMed
25.
Zurück zum Zitat Sud AR, Tan ST (2010) Pyogenic granuloma-treatment by shave-excision and/or pulsed-dye laser. J Plast Reconstr Aesthet Surg 63(8):1364–1368CrossRefPubMed Sud AR, Tan ST (2010) Pyogenic granuloma-treatment by shave-excision and/or pulsed-dye laser. J Plast Reconstr Aesthet Surg 63(8):1364–1368CrossRefPubMed
26.
Zurück zum Zitat Bourguignon R, Paquet P, Piérard-Franchimont C, Piérard GE (2006) Treatment of pyogenic granulomas with the Nd-YAG laser. J Dermatolog Treat 17(4):247–249CrossRefPubMed Bourguignon R, Paquet P, Piérard-Franchimont C, Piérard GE (2006) Treatment of pyogenic granulomas with the Nd-YAG laser. J Dermatolog Treat 17(4):247–249CrossRefPubMed
27.
Zurück zum Zitat Bédard MS, Boulanger J (2009) Treatment of lobular capillary hemangioma with the Nd:YAG laser: retrospective case series of 25 patients. J Cutan Med Surg 13(3):181–182CrossRefPubMed Bédard MS, Boulanger J (2009) Treatment of lobular capillary hemangioma with the Nd:YAG laser: retrospective case series of 25 patients. J Cutan Med Surg 13(3):181–182CrossRefPubMed
28.
Zurück zum Zitat Hammes S, Kaiser K, Pohl L, Metelmann HR, Enk A, Raulin C (2012) Pyogenic granuloma: treatment with the 1,064-nm long-pulsed neodymium-doped yttrium aluminum garnet laser in 20 patients. Dermatol Surg 38(6):918–923CrossRefPubMed Hammes S, Kaiser K, Pohl L, Metelmann HR, Enk A, Raulin C (2012) Pyogenic granuloma: treatment with the 1,064-nm long-pulsed neodymium-doped yttrium aluminum garnet laser in 20 patients. Dermatol Surg 38(6):918–923CrossRefPubMed
Metadaten
Titel
Efficacy of Nd-YAG laser for treatment of pyogenic granuloma on the fingers and toes
verfasst von
J. Dong
S. G. Peng
X. Y. Zhang
C. G. Tong
F. Liu
M. Cao
Y. H. Li
Y. L. He
Publikationsdatum
11.07.2018
Verlag
Springer London
Erschienen in
Lasers in Medical Science / Ausgabe 1/2019
Print ISSN: 0268-8921
Elektronische ISSN: 1435-604X
DOI
https://doi.org/10.1007/s10103-018-2577-7

Weitere Artikel der Ausgabe 1/2019

Lasers in Medical Science 1/2019 Zur Ausgabe