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25.11.2017 | Review Article | Ausgabe 2/2018

Lasers in Medical Science 2/2018

Efficacy of photodynamic therapy as adjunct treatment of chronic periodontitis: a systematic review and meta-analysis

Zeitschrift:
Lasers in Medical Science > Ausgabe 2/2018
Autoren:
Adriano Azaripour, Sebastian Dittrich, Cornelis J. F. Van Noorden, Brita Willershausen
Wichtige Hinweise

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s10103-017-2383-7) contains supplementary material, which is available to authorized users.

Abstract

Meta-analysis of treatment effects of antimicrobial photodynamic therapy (aPDT) adjunct to non-surgical scaling and root planing (SRP) in comparison to SRP alone on patients with chronic periodontitis. The meta-analysis was performed according to PRISMA statement and Cochrane Collaboration guidelines. Electronic search complemented by hand search assured a high yield of randomized controlled trials (RCTs) of aPDT as adjunct modality to SRP. Differences in probing depth (PD) and clinical attachment level (CAL) were calculated with 95% confidence intervals and pooled in a random effects model. Analysis for intra- and inter-study heterogeneity was provided by χ 2 and I 2 tests, and publication bias was checked by funnel plots. Pooled overall effects of 26 RCTs attested significant benefits of aPDT adjunct to SRP with respect to PD reduction (MD 0.37; 95% CI 0.12–0.53; P < 0.0001) and CAL gain (MD 0.33; 95% CI 0.19–0.48; P < 0.00001) after 3 and 6 months. Sensitivity analysis minimized heterogeneity of PD reduction (MD 0.21; 95% CI 0.13–0.30; P < 0.00001) and CAL gain (MD 0.36; 95% CI 0.27–0.46). aPDT adjunct to SRP provides significant PD reduction and CAL gain in treatment of chronic periodontitis. This moderate effect was found after 3 and 6 months which is short from a clinical perspective.

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Zusatzmaterial
Appendix Fig. 1 Forest plot of PD reduction and CAL gain after 3 month (JPEG 2366 kb)
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Appendix Fig. 2 Forest plot of PD reduction and CAL gain after 6 month (JPEG 1857 kb)
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Appendix Fig. 3 Forest plot of PD reduction and CAL gain after 12 month (JPEG 1817 kb)
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Appendix Fig. 4 Forest plot of PD reduction and CAL gain after various incubation periods with photosensitizer (JPEG 2356 kb)
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Appendix Fig. 5 Forest plot of PD reduction and CAL gain after various periods of activation time of photosensitizer (JPEG 2377 kb)
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Appendix Fig. 6 Forest plot of PD reduction and CAL gain in studies with low bias risk (JPEG 1932 kb)
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Appendix Fig. 7 Forest plot of PD reduction and CAL gain in studies with high bias risk (JPEG 2187 kb)
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Appendix Fig. 8 Funnel plot of overall PD reduction (JPEG 1415 kb)
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Appendix 1 Search strategy (DOCX 15 kb)
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Appendix 2 Flow diagram according to the PRISMA Statement (JPEG 2187 kb)
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Appendix 3 Modified quality assessment according to the Cochrane Handbook for Systematic Reviews of Interventions (DOCX 43 kb)
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Appendix 4 Excluded studies from systematic review with reasons for exclusion (DOCX 57 kb)
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ESM 1 Appendix list of references (DOCX 20 kb)
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