Introduction
Colorectal cancer is the third most common malignancy worldwide, but its mortality is considerably lower than that of other cancers [
1]. Although surgical techniques and instruments have been greatly improved, many patients with rectal cancer still suffer permanent colon stoma. Parastomal hernia is a common complication of end-colostomy. The incidence of parastomal hernia varies from 16 to 57 % [
2,
3]. Because patients with rectal cancer usually survive for long periods, the incidence of the parastomal hernia may be even higher than reported.
Parastomal hernia can not only significantly reduce patients’ quality of life, but also cause a variety of specific complications such as pain, bleeding, bowel obstruction, and bowel strangulation [
4,
5]. Although not all cases of parastomal hernia require surgical repair, there are a variety of surgical techniques. Local fascial repair, relocation of the stoma, and local repair of the parietal defect using meshes are the three basic methods of repair. The surgical approach may be open or laparoscopic. The treatment results were disappointing due to the 16–52 % recurrence rate and about 14–23 % other complications [
6‐
9].
Because of the unsatisfactory results of existing treatments, it has been proposed that the best solution is to prevent parastomal hernia at the time of stoma formation. Some studies have found that prophylactic placement of mesh was associated with a significant reduction the occurrence of parastomal hernia without increasing morbidity [
10], but this association was not found in other studies [
11]. For this reason, a systematic review and meta-analysis of randomized controlled trials was performed to determine the efficacy and safety of prophylactic mesh in patients with rectal cancer after end-colostomy.
Materials and methods
This systematic review and meta-analysis was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) [
12].
Literature search and inclusion criteria
Two authors (S.W. and B.Z.) independently searched electronic databases (inception to September 2015) including PubMed, Embase, and the Cochrane Library. Search terms included “rectal neoplasms,” “rectal cancer,” “colostomy,” “surgical mesh,” and “parastomal hernia,” and were searched in titles and abstracts. Free text searches and MeSH searches were performed. The search had no language restrictions. References of the articles included were also read to identify related articles.
Studies that met the following criteria were included: (1) population: patients receiving permanent end-colostomy surgery (Miles or Hartmann operation) to treat cancer of the rectum; (2) intervention: mesh insertion at the time of formation of end-colostomy; (3) comparison: no mesh insertion at the time of formation of end-colostomy; (4) outcome measure: the incidence of parastomal hernia; (5) study design: RCT.
Two authors independently extracted the data (S.W. and W.W.), and discrepancies were resolved through discussion. When no consensus could be reached, a third specialist was consulted (C.J.). The following information was extracted from each selected study: first author, year of publication, publishing country, published journal, type of mesh, position of mesh placement, location of stoma, and diagnostic bases of parastomal hernia. The primary outcome was the incidence of parastomal hernia. Secondary outcomes included stoma-related morbidity and reoperation related to parastomal hernia. Parastomal hernia was defined clinically and radiologically by a CT scan performed to identify possible subclinical parastomal hernia [
13].
Assessment for risk of bias was conducted in accordance with the
Cochrane handbook for systematic reviews of interventions (version 5.1.0) by two authors (S.W. and G.S.) [
14]. Risk of bias was judged as “low risk,” “unclear risk,” and “high risk” according to the following domains: random sequence generation, allocation concealment, blinding of participants and personnel, blinding of outcome assessment, incomplete outcome data, selective reporting, and other bias.
The overall quality of the evidence for each outcome was evaluated using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach [
15]. GRADE Working Group grades of evidence were as follows: high quality: further research is very unlikely to change our confidence in the estimate of effect; moderate quality: further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate; low quality: further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate; and very low quality: any estimate of effect is very uncertain.
Statistical analysis
Pooled RR and 95 % CI were estimated for each outcome. Statistical heterogeneity was assessed using χ
2 and
I
2
statistics. Heterogeneity was considered significant if the
P value (χ
2) was <0.1 and
I
2
was >50 %. A random effects model was used regardless of heterogeneity. Whenever significant heterogeneity was present, possible sources of heterogeneity were assessed. For instance, a sensitivity analysis was performed and the study was excluded if the results were outside the range established by the others. Subgroup analysis was also performed, and the subgroups were based on the position of mesh placement (sublay vs. IPOM). The effects of treatment in different subgroups were compared using tests for interaction. The
P value <0.05 supports a different treatment effect in the tested subgroups [
16]. Potential publication bias was assessed by a visual inspection of the Begg's funnel plots where the log RR was plotted against their standard errors. The Begg’s test was used to measure the potential presence of publication bias [
17]. Statistical analysis was performed with Stata 12.0 (Stata Corporation, College Station, TX, USA) and RevMan 5.3 (Nordic Cochrane Centre, Cochrane Collaboration, Copenhagen, Denmark).
Discussion
Our study evaluated efficacy of prophylactic mesh at end-colostomy construction. The results revealed that, for sigmoid end-colostomy, prophylactic placement of a mesh reduced the incidence of parastomal hernia, reoperation related to parastomal hernia, and made no significant difference in terms of stoma-related morbidity.
These results were similar to those published in a previous meta-analysis by Wijeyekoon et al. [
38]. However, the selection of the study population was different between these two studies. The prior study included all patients with end and loop stomas. Because the incidence of parastomal hernia was different between end and loop stomas [
39,
40], the present study only included those patients who underwent permanent end-colostomy surgery to treat cancer of the rectum. The prior analysis only included three articles involving a total of 129 patients. The present meta-analysis included more recently published articles and a greater number of patients than Wijeyekoon et al. did; therefore, it was more likely to detect differences.
Parastomal hernia is caused by enlargement of the trephine opening in the abdominal wall, which is usually due to the working of mechanical tangential stress on the circumference of the opening. Reinforcing the abdominal wall with mesh during the initial operation might reduce the incidence of parastomal hernia. The mesh group was found to have a distinct advantage over the non-mesh group with respect to the incidence of the parastomal hernia. In the studies included here, mesh was placed as a sublay or in the intraperitoneal plane. The sublay technique is considered feasible and can lower the incidence of parastomal hernia [
10]. The intraperitoneal technique includes the modified Sugarbaker method, the keyhole technique, and the sandwich technique. The keyhole technique involves cutting a hole in the mesh to destroy its architecture and reduce its tensile strength, resulting in gradual widening of the opening. The modified Sugarbaker technique is believed to be superior to the keyhole technique because it is associated with fewer recurrences [
41,
42]. Although the keyhole technique was used on more patients than the modified Sugarbaker technique in the included studies, the incidence of parastomal hernia was lower in mesh group than that in non-mesh group.
What concerns surgeons is the risk of complications attributable to insertion of a prosthetic material into a potentially contaminated field such as an open bowel. They are particularly concerned about the risk of wound infection, which may necessitate mesh removal. The intraperitoneal technique is an aseptic procedure involving no contact between the mesh and the broken ends of the transected colon. The sigmoid colon used to create the stoma is passed through the abdominal wall before the mesh is placed. In this meta-analysis, there were no cases of mesh removal for the reason of infection in cases treated with the sublay technique. This may be because of the lower rate of inflammatory reaction and better defense against infection with large-pore lightweight mesh [
43]. After preparation of the bowel and the management of pollution, mesh can be used in the presence of open bowel with minimal risk of infection [
44,
45]. Although Aldridge [
46] reported a case of erosion and perforation of colon by synthetic mesh, this complication is rare, and improvements to materials and techniques have made it rarer. In the studies examined here, stoma detachment and necrosis of the colostomy were more common than erosion or perforation, and it was not the mesh but the blood supply and tension of sigmoid colon that cause these complications. In this way, no significant differences in stoma-related complications were found between the two groups.
Analysis showed the mesh group to have advantages not only related to the incidence of the parastomal hernia but also related to reoperation for parastomal hernia. The significant increases in aperture size were observed in the non-mesh group after CT scan [
32], which can cause discomfort, may go some way toward explaining this.
Even though the results are encouraging, there are still factors that must be considered. Some of the patients in the mesh group died from recurrence of cancer within 12 months. Even when it was assumed that everyone in the mesh group who died had developed a parastomal hernia, the results of the meta-analysis did not change. It is not appropriate to place a mesh in patients whose survival time is less than 1 year. Once these patients are excluded, prophylactic mesh placement can be considered cost-effective. The incremental cost-effectiveness ratio (ICER) was $6676/QALY (quality adjusted life years) [
47]. Several studies have found female gender, higher body mass index, and lower levels of preoperative albumin to offer significant independent risk for parastomal hernia [
48,
49]. However, none of the studies evaluated the placement of mesh in these specific patients. This may be a suitable subject for future studies.
This study has a number of limitations that should be considered. First, there are different protocols for diagnosis of parastomal hernia. Parastomal hernia, whether diagnosed by clinical examination or by CT scan, has no consistent definition. Clinical examination is a subjective method, and it can be especially difficult to identify parastomal hernia in obese patients. Although CT scanning is an objective method, it is subject to false negatives. A definition of parastomal hernia for use with clinical examination that matches findings from CT scans should be established [
50]. Second, the follow-up period was different in different studies, though it was more than 12 months in most of them. Although most cases of parastomal hernia appear within the first 12 months of construction, a higher incidence of parastomal hernia is reported with longer follow-up [
19,
25]. Future trials should have follow-up times of 12 months or longer. Finally, although we included RCT, some of the following factors might still produce a biased estimate of the effects of treatment effect. Random sequence generation was adequate in only three of the studies included here. Only one study provided sufficient information to assess allocation concealment, and it did so inadequately. Blinding of outcome assessment was used in two of the included studies.
In conclusion, available evidence suggests that prophylactic mesh at end-colostomy construction after surgery for low rectal cancer is an effective and safe procedure. However, the results should be interpreted with caution because of the heterogeneity among the studies and prophylactic mesh placement in all patients or in patients with specific needs requires further study.