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06.04.2018 | Hepatobiliary Tumors | Ausgabe 6/2018

Annals of Surgical Oncology 6/2018

Efficacy of the Gallbladder Cancer Predictive Risk Score Based on Pathological Findings: A Propensity Score-Matched Analysis

Zeitschrift:
Annals of Surgical Oncology > Ausgabe 6/2018
Autoren:
MD Tetsuya Mochizuki, MD Tomoyuki Abe, MD, PhD Hironobu Amano, MD, PhD Keiji Hanada, PhD Minoru Hattori, MD, PhD Tsuyoshi Kobayashi, MD, PhD Masahiro Nakahara, MD, PhD Hideki Ohdan, MD, PhD Toshio Noriyuki
Wichtige Hinweise

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1245/​s10434-018-6444-3) contains supplementary material, which is available to authorized users.

Abstract

Background

The optimal prognostic predictive system for gallbladder carcinoma (GBC) has not been established. The gallbladder cancer predictive risk score (GBRS) based on pathological findings identifies incidental GBC patients at risk of recurrence.

Objective

We aimed to validate the prognostic ability of the GBRS in all GBC patients following curative surgery.

Methods

Fifty-six patients with GBC who underwent curative surgery between 1996 and 2016 were included in this study. Univariate and multivariate analyses were performed to determine prognostic factors associated with overall and recurrence-free survival, and propensity score-matched analysis was performed.

Results

The median patient age was 71.9 years, and 39.3% of patients were males. All patients underwent curative surgery (33.9%, simple cholecystectomy; 66.1%, more advanced procedures, such as hepatectomy; and 32.1%, bile duct reconstruction). On univariate analysis, preoperative carbohydrate antigen 19-9 (CA19–9) ≥ 37 U/mL (p = 0.042), postoperative complications (p = 0.043), and a high GBRS (p < 0.001) were prognostic factors for worse overall survival. On multivariate analysis, CA19–9 ≥ 37 U/mL (p = 0.039 and p = 0.043, respectively) and a high GBRS (p = 0.001 and p = 0.010, respectively) were independent risk factors for poor overall and recurrence-free survival. After propensity score-matched analysis, the GBRS precisely predicted prognosis of patients with GBC.

Conclusions

The GBRS is an easy and novel prognostic predicting score. Our validation revealed good discrimination, suggesting its clinical utility to improve individualized prediction of survival for patients undergoing resection of GBC.

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Zusatzmaterial
Supplementary material 1 (PDF 220 kb)
10434_2018_6444_MOESM1_ESM.pdf
Supplementary material 2 (DOC 43 kb)
10434_2018_6444_MOESM2_ESM.doc
Literatur
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