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29.08.2018 | Original Article

Efficacy of urinary glucose for diabetes screening: a reconsideration

verfasst von: Juan Chen, Haijian Guo, Suixia Yuan, Chen Qu, Tao Mao, Shanhu Qiu, Wei Li, Xiaohang Wang, Min Cai, Hong Sun, Bei Wang, Xiaoning Li, Zilin Sun

Erschienen in: Acta Diabetologica | Ausgabe 1/2019

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Abstract

Aims

Previous studies indicated that urinary glucose (UG) had a limited efficacy in diabetes screening. This study was designed to have a re-evaluation of its efficacy, taking into consideration the collection method of urine and the measurement approach for UG among Chinese adults.

Methods

This cross-sectional study enrolled a total of 7689 participants without known diabetes, who were fasted and asked to empty bladders before a 75 g glucose loading. Urine was collected 2 h post glucose loading, and UG was measured using quantitative and qualitative approaches. The efficacy of UG in detecting diabetes was assessed by the receiver operating characteristic (ROC) curve.

Results

The area under the ROC curve was 0.89 for quantitative UG and 0.87 for qualitative UG. Quantitative UG was positively correlated with fasting plasma glucose (FPG) and 2 h plasma glucose (2 h PG) (r = 0.55 and 0.56, respectively, both P < 0.001). Quantitative UG displayed a sensitivity of 82.9% and a specificity of 84.7% in detecting diabetes at the corresponding optimal cutoff of 130 mg. Qualitative UG exhibited a sensitivity of 80.2% and a specificity of 85.6% at the optimal cutoff of glycosuria + 1. In addition, the sensitivity of both quantitative and qualitative UG was significantly higher than that of HbA1c (≥ 6.5%) (P < 0.001) and had a comparable sensitivity to 2 h PG (≥ 11.1 mmol/L) (P = 0.493).

Conclusions

UG, either quantitatively or qualitatively measured at 2 h post glucose loading, was effective in diabetes screening. This indicates that UG is a feasible approach for diabetes screening.

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Titel: Efficacy of urinary glucose for diabetes screening: a reconsideration
verfasst von: Juan Chen
Haijian Guo
Suixia Yuan
Chen Qu
Tao Mao
Shanhu Qiu
Wei Li
Xiaohang Wang
Min Cai
Hong Sun
Bei Wang
Xiaoning Li
Zilin Sun
Publikationsdatum: 29.08.2018
Verlag: Springer Milan
Erschienen in: Acta Diabetologica / Ausgabe 1/2019
Print ISSN: 0940-5429
Elektronische ISSN: 1432-5233
DOI: https://doi.org/10.1007/s00592-018-1212-1

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Efficacy of urinary glucose for diabetes screening: a reconsideration

Abstract

Aims

Methods

Results

Conclusions

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Parodontalbehandlung verbessert Prognose bei Katheterablation

Prostatakarzinom: EU initiiert neues Screeningkonzept

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Update Innere Medizin

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Aims

Methods

Results

Conclusions

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