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01.12.2014 | Meeting abstract | Sonderheft 1/2014 Open Access

The Journal of Headache and Pain 1/2014

EHMTI-0102. Prospective analysis of the use of onabotulinumtoxina (botox®) In the treatment of chronic migraine; real-life data in 299 patients from hull, UK

The Journal of Headache and Pain > Sonderheft 1/2014
M Khalil, H Zafar, V Quarshie, F Ahmed


Chronic migraine (CM) affects 2% of the general population with substantial impact on quality of life. The efficacy and safety of Botox in CM was confirmed in the phase III Research Evaluating Migraine Prophylaxis Therapy (PREEMPT) clinical programme. Despite this, few data exist in the real-life setting.


To evaluate the efficacy of Botox in adults with CM in real-life setting.


Adult patients with CM attending the Hull migraine clinic were offered Botox based on clinical needs using the PREEMPT protocol. Headache diaries were maintained for at least 30 days prior to and continuously after Botox (July 2010 and January 2014). Data were extracted for headache, migraine, and headache-free days. A responder was defined as one with either a 50% reduction in either headache days or migraine days an increment in crystal clear days twice that of the baseline.


Of a series of 331 patients, full data were available on 299 patients There was significant decrement in headache and migraine days as well as similarly significant increment in headache-free days. Responder rate was calculated for the above mentioned 3 categories.


Our analysis has shown that, in a real-life clinical setting, Botox can effectively reduce headache and migraine days, and increase crystal clear days from baseline. Our cohort represent a more severely affected population than seen in PREEMPT study; furthermore the pre-treatment headache days’ number was higher in our patients . We are hoping to present the data on 500 patients as we continue to treat patients.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( https://​creativecommons.​org/​licenses/​by/​4.​0), which permits use, duplication, adaptation, distribution, and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
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