Introduction
Outcomes of migraine (M) in the elderly as well as age-related neurophysiological changes are poorly studied.
Aim of study was to evaluate cortical excitability changes in M patients depending on patient’s age and M outcome.
Methods
Study groups comprised: 20 young (aged 20-49, YM) and 35 elderly pts (aged 50-70, EM) with ongoing typical M attacks; 11 elderly pts (aged 50-70) with complete M cessation by now and typical M course in the past (No more M) and 7 pts of any age with partial M cessation (preservation of M aura without headache) - Late Life Migraine Equivalents (LLME). Diagnosis was based on ICHD-2, 2004. Control groups: healthy subjects without headache (n=15 aged 20-49, n=15 aged 50-70). The RP-VEP test was carried out in a period free from migraine attacks.
Results
Significant increase in total N75-P100 (p<0,05) and more marked dyshabituation were obtained in YM (7,74±2,7 and -8.1%), EM (7,85±3,9 and -2.3%) and LLME groups (8.7±2.5 and -0.76%) compared to group no more M (5.6±1,5) and both control groups without M anamnesis (6,85±2,6 and -14.4%; 6,24±2,6 and -15.1%).
Conclusions
Our study has shown that patients with active M and those keeping M aura but shedding headache phase (LLME) demonstrate neurophysiological pattern typical for M reflecting cortical hyperexcitability which could be the basis for M preservation in any age. On the contrary, in patients of any age with complete M cessation we revealed complete normalization of both indexes which appeared comparable to subjects who never suffered from M.
No conflict of interest.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (
https://creativecommons.org/licenses/by/4.0), which permits use, duplication, adaptation, distribution, and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.