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01.12.2014 | Meeting abstract | Sonderheft 1/2014 Open Access

The Journal of Headache and Pain 1/2014

EHMTI-0174. Dural vessel hemodynamics during normal behavior and migraine attack

Zeitschrift:
The Journal of Headache and Pain > Sonderheft 1/2014
Autoren:
Y Gao, P Drew

Introduction

Migraine is hypothesized to be caused by the pathological dilation of blood vessels in the dura.

Aims

To better understand the vascular pathology of migraine, we measured dural vessel diameter changes during normal behavior and under pharmacologically-induced migraine attack in awake behaving mice.

Methods

We use two-photon laser scanning microscopy (2PLSM) to concurrently measure dural and pial surface vessel diameters down to micrometer resolution. Measurements were made in the somatosensory cortex of awake, head-fixed mice on a spherical treadmill, which allowed the mice to voluntarily run.

Results

A majority of the dural vessels constricted during locomotion (n=29 vessels in 11 mice, peak constriction=–11.2%±5.7%), some of them did not respond (8 vessels in 4 mice), while there were a few dilated (3 vessels in 2 mice, peak dilation=12.2%±3.3%). In the contrast, all the pial vessels dilated during locomotion, with arteries showing rapid and large dilation (19.7%±8.2%) and veins showing a slower and smaller dilation (6.6%±3.2%). Preliminary experiment shows that injecting CGRP, which is believed to provoke migraine, drives the dilation of dural vessels.

Conclusions

Dural vessels exhibit diverse dynamics during locomotion, but the dominant effect was constriction. The differences between dural and pial vessels have never been reported before, but may indicate a unique function of dural vessels during exercise. This work provides novel insights into the normal dynamics of dural vessels during behavior and their disfunction during migraine.
No conflict of interest.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( https://​creativecommons.​org/​licenses/​by/​4.​0), which permits use, duplication, adaptation, distribution, and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
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