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01.12.2014 | Meeting abstract | Sonderheft 1/2014 Open Access

The Journal of Headache and Pain 1/2014

EHMTI-0299. Serotonin as biomarker of ache intensity in chronic tension headache

The Journal of Headache and Pain > Sonderheft 1/2014
I Karakulova


Tension headache (TH) belongs to most frequent type of the idiopathic cephalalgies. Depression and serotonins metabolism disorders play a leading role in the pathogenesis of TH.


Study the dependence of the intensity of the TH of degree of depression, anxiety and levels of serum serotonin.


The complex algic, psychometric test and determination of concentration of blood serum serotonin (S) by the method of immunoenzyme analysis were performed in 140 patients with TH.


At patients of first group the intensity of episodic TH (44 man) was 56±4,32 mm according to 100-mm visual analogue scale. All patients of this group had high level of reactive anxiety (50,18±8,6, p<0,05), moderate level of depression and tendency to the decreasing of blood S concentration (205,72±21,62 ng/ml). The second group consists of 96 patients with chronic TH. Straight correlation between duration and intensity of ache, indices of reactive and personal anxiety (46,81±8,8 and 54,2+9,64 accordingly), high depression level (23,6±4,52 points in according with Bek scale, p=0,001) and significant decreasing of blood S concentration (119,38±19,42 ng/ml, p=0,046) was determined in all patients of this group.


Concentration of blood serum serotonin depends on duration and intensity of ache, level of depression and anxiety. Therefore, serotonin of blood serum can be used as biomarker of ache intensity, level of depression.
No conflict of interest.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( https://​creativecommons.​org/​licenses/​by/​4.​0), which permits use, duplication, adaptation, distribution, and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
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