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Erschienen in: The Journal of Headache and Pain 1/2014

Open Access 01.12.2014 | Meeting abstract

EHMTI-0328. Comparative evaluation of pregabalin, gabapentin, carbamazepine and topiramat in migraine

verfasst von: A Docu Axelerad, D Docu Axelerad

Erschienen in: The Journal of Headache and Pain | Sonderheft 1/2014

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Objective

To compare the efficacy and safety of of pregabalin, gabapentin, carbamazepine and topiramat in migraine.

Research design and methods

In this observational study, 24 patients received pregabalin, gabapentin, carbamazepine and topiramat orally twice daily, each for 6 month with optional dose up titration (divided in four groups, each group has 6 patients). Pain diagnosis of migraine was made according to the second edition of the International Classification of Headache Disorders (ICHD-2) criteria and pain relief was measured by the patient’s global assessment of efficacy, using the Migraine Disability Assessment Questionnaire (MIDAS). Treatment goals include restoring function and improving pain control.

Results

There was a significant improvement in pain with all treatments compared with their baseline values. There were no significant differences in various other outcome measures between the groups.

Conclusions

Both carbamazepine and topiramat demonstrated similar efficacy in migraine but pregabalin, gabapentin was less effective on pain.
No conflict of interest.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (https://​creativecommons.​org/​licenses/​by/​4.​0), which permits use, duplication, adaptation, distribution, and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Metadaten
Titel
EHMTI-0328. Comparative evaluation of pregabalin, gabapentin, carbamazepine and topiramat in migraine
verfasst von
A Docu Axelerad
D Docu Axelerad
Publikationsdatum
01.12.2014
Verlag
Springer Milan
Erschienen in
The Journal of Headache and Pain / Ausgabe Sonderheft 1/2014
Print ISSN: 1129-2369
Elektronische ISSN: 1129-2377
DOI
https://doi.org/10.1186/1129-2377-15-S1-G7

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