Skip to main content

01.12.2014 | Meeting abstract | Sonderheft 1/2014 Open Access

The Journal of Headache and Pain 1/2014

EHMTI-0368. Treatment of migraine attacks as suggested by Dr. John R. Graham in 1955. A historical analysis with current implications

The Journal of Headache and Pain > Sonderheft 1/2014
P Tfelt-Hansen, E Loder


In 1955 Dr. John R. Graham, an astute clinician, published 3 influential papers on migraine theories and mainly on treatment of migraine in the New England Journal of Medicine [1,2,3]. Many of Dr. Graham’s clinical observations remain relevant to current methods of treating migraine attacks and some of his examples of suggestions are shown below.
Examples of suggestions on ergot therapy:
The patient should be checked regarding to diagnosis of migraine and possible contraindications to ergot therapy.
The ergot dose should be carefully selected as the minimally effective dose.
The patient should be instructed to use ergot as early in the attack as he can make the diagnosis of “one of his migraine.”
He should be urged to use the selected amount of ergot at the start rather than to distribute it over several hours.
Ergot derivatives should not be considered a failure until ergotamine tartrate has been given, early in an attack, by the parenteral route.


If the word “ergot” is replaced with” triptans” Dr. Graham thus seemingly anticipated in 1955 optimal modern acute treatment of migraine.
No conflict of interest.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( https://​creativecommons.​org/​licenses/​by/​4.​0), which permits use, duplication, adaptation, distribution, and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Über diesen Artikel

Weitere Artikel der Sonderheft 1/2014

The Journal of Headache and Pain 1/2014 Zur Ausgabe

Neu im Fachgebiet AINS

Mail Icon II Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update AINS und bleiben Sie gut informiert – ganz bequem per eMail.