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01.12.2014 | Short report | Ausgabe 1/2014 Open Access

Diabetology & Metabolic Syndrome 1/2014

Eicosapentaenoic acid/arachidonic acid ratio and smoking status in elderly patients with type 2 diabetes mellitus

Zeitschrift:
Diabetology & Metabolic Syndrome > Ausgabe 1/2014
Autoren:
Kenta Okada, Kazuhiko Kotani, Hiroaki Yagyu, Shun Ishibashi
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1758-5996-6-85) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no conflict of interest.

Authors’ contributions

KO researched the data, drafted the manuscript, and contributed to the discussion. KK analyzed the data, edited, and reviewed the manuscript. HY contributed to the discussion. SI contributed to discussing and reviewing the manuscript. All authors read and approved the final manuscript.

Abstract

Background

A low ratio of eicosapentaenoic acid (EPA)/arachidonic acid (AA) is considered a risk factor for cardiovascular disease. Smoking is also a risk factor for cardiovascular disease even in an elderly population. This study investigated the relationship between EPA/AA ratio and smoking status among elderly patients with type 2 diabetes mellitus (T2DM).

Findings

A total of 188 elderly patients with T2DM (men/women, 114/74; mean age, 65.0 ± 7.5 years) were studied in terms of their smoking status, diabetic conditions, and blood data, including EPA and AA. Current smokers showed a lower EPA/AA ratio than non-smokers (current smokers: 0.29, n = 49; non-smokers: 0.39, n = 139, p < 0.01). This relationship remained significant after adjusting for multiple variables.

Conclusions

Smoking may affect the EPA/AA ratio among elderly patients with T2DM, suggesting a possible mechanism of cardiovascular disease development and indicating the importance of smoking secession in such patients.
Zusatzmaterial
Authors’ original file for figure 1
13098_2014_347_MOESM1_ESM.doc
Literatur
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