Skip to main content
Erschienen in:

06.04.2019 | Review Article

Electrical stimulation-based bone fracture treatment, if it works so well why do not more surgeons use it?

verfasst von: Mit Balvantray Bhavsar, Zhihua Han, Thomas DeCoster, Liudmila Leppik, Karla Mychellyne Costa Oliveira, John H Barker

Erschienen in: European Journal of Trauma and Emergency Surgery | Ausgabe 2/2020

Einloggen, um Zugang zu erhalten

Abstract

Background

Electrical stimulation (EStim) has been proven to promote bone healing in experimental settings and has been used clinically for many years and yet it has not become a mainstream clinical treatment.

Methods

To better understand this discrepancy we reviewed 72 animal and 69 clinical studies published between 1978 and 2017, and separately asked 161 orthopedic surgeons worldwide about their awareness, experience, and acceptance of EStim for treating fracture patients.

Results

Of the 72 animal studies, 77% reported positive outcomes, and the most common model, bone, fracture type, and method of administering EStim were dog, tibia, large bone defects, and DC, respectively. Of the 69 clinical studies, 73% reported positive outcomes, and the most common bone treated, fracture type, and method of administration were tibia, delayed/non-unions, and PEMF, respectively. Of the 161 survey respondents, most (73%) were aware of the positive outcomes reported in the literature, yet only 32% used EStim in their patients. The most common fracture they treated was delayed/non-unions, and the greatest problems with EStim were high costs and inconsistent results.

Conclusion

Despite their awareness of EStim’s pro-fracture healing effects few orthopedic surgeons use it in their patients. Our review of the literature and survey indicate that this is due to confusion in the literature due to the great variation in methods reported, and the inconsistent results associated with this treatment approach. In spite of this surgeons seem to be open to using this treatment if advancements in the technology were able to provide an easy to use, cost-effective method to deliver EStim in their fracture patients. 
Literatur
1.
Zurück zum Zitat Garrat AC. Electrophysiology and electrotherapeutics. Boston: Ticknor and Fields; 1860. Garrat AC. Electrophysiology and electrotherapeutics. Boston: Ticknor and Fields; 1860.
3.
Zurück zum Zitat Chalidis B, Sachinis N, Assiotis A, Maccauro G, Graziani F. Stimulation of bone formation and fracture healing with pulsed electromagnetic fields: biologic responses and clinical implications. Int J Immunopathol Pharmacol. 2011;24:17–20.CrossRefPubMed Chalidis B, Sachinis N, Assiotis A, Maccauro G, Graziani F. Stimulation of bone formation and fracture healing with pulsed electromagnetic fields: biologic responses and clinical implications. Int J Immunopathol Pharmacol. 2011;24:17–20.CrossRefPubMed
4.
Zurück zum Zitat Aaron RK, Boyan BD, Ciombor DM, Schwartz Z, Simon BJ. Stimulation of growth factor synthesis by electric and electromagnetic fields [review]. Clin Orthop. 2004;419:30–7.CrossRef Aaron RK, Boyan BD, Ciombor DM, Schwartz Z, Simon BJ. Stimulation of growth factor synthesis by electric and electromagnetic fields [review]. Clin Orthop. 2004;419:30–7.CrossRef
5.
Zurück zum Zitat Simonis RB, Parnell EJ, Ray PS, Peacock JL. Electrical treatment of tibial non-union: a prospective, randomised, double-blind trial. Injury. 2003;34:357–62.CrossRefPubMed Simonis RB, Parnell EJ, Ray PS, Peacock JL. Electrical treatment of tibial non-union: a prospective, randomised, double-blind trial. Injury. 2003;34:357–62.CrossRefPubMed
6.
Zurück zum Zitat Andersen T, Christensen FB, Ernst C, Fruensgaard S, Østergaard J, Andersen JL, et al. The effect of electrical stimulation on lumbar spinal fusion in older patients: a randomized, controlled, multi-center trial: part 1: functional outcome. Spine. 2009;34:2241–7.CrossRefPubMed Andersen T, Christensen FB, Ernst C, Fruensgaard S, Østergaard J, Andersen JL, et al. The effect of electrical stimulation on lumbar spinal fusion in older patients: a randomized, controlled, multi-center trial: part 1: functional outcome. Spine. 2009;34:2241–7.CrossRefPubMed
7.
Zurück zum Zitat Steinberg ME, Brighton CT, Hayken GD, Tooze SE, Steinberg DR. Early results in the treatment of avascular necrosis of the femoral head with electrical stimulation. Orthop Clin N Am. 1984;15:163–75. Steinberg ME, Brighton CT, Hayken GD, Tooze SE, Steinberg DR. Early results in the treatment of avascular necrosis of the femoral head with electrical stimulation. Orthop Clin N Am. 1984;15:163–75.
8.
Zurück zum Zitat Sharrard WJ, Sutcliffe ML, Robson MJ, Maceachern AG. The treatment of fibrous non-union of fractures by pulsing electromagnetic stimulation. J Bone Jt Surg Br. 1982;64:189–93.CrossRef Sharrard WJ, Sutcliffe ML, Robson MJ, Maceachern AG. The treatment of fibrous non-union of fractures by pulsing electromagnetic stimulation. J Bone Jt Surg Br. 1982;64:189–93.CrossRef
9.
Zurück zum Zitat Brighton C, Shaman P, Heppenstall R. Tibial nonunion treated with direct current, capacitive coupling, or bone graft. Clin Orthop. 1995;321:223–34. Brighton C, Shaman P, Heppenstall R. Tibial nonunion treated with direct current, capacitive coupling, or bone graft. Clin Orthop. 1995;321:223–34.
10.
Zurück zum Zitat Borsalino G, Bagnacani M, Bettati E, et al. Electrical stimulation of human femoral intertrochanteric osteotomies. Clin Orthop. 1988;237:256–63. Borsalino G, Bagnacani M, Bettati E, et al. Electrical stimulation of human femoral intertrochanteric osteotomies. Clin Orthop. 1988;237:256–63.
11.
Zurück zum Zitat Bassett CA, Mitchell SN, Schink MM. Treatment of therapeutically resistant non-unions with bone grafts and pulsing electromagnetic fields. J Bone Jt Surg Am. 1982;64:1214–20.CrossRef Bassett CA, Mitchell SN, Schink MM. Treatment of therapeutically resistant non-unions with bone grafts and pulsing electromagnetic fields. J Bone Jt Surg Am. 1982;64:1214–20.CrossRef
12.
Zurück zum Zitat Steinberg ME, Brighton CT, Corces A, Hayken GD, Steinberg DR, Strafford B, et al. Osteonecrosis of the femoral head. Results of core decompression and grafting with and without electrical stimulation. Clin Orthop Relat Res. 1989;249:199–208. Steinberg ME, Brighton CT, Corces A, Hayken GD, Steinberg DR, Strafford B, et al. Osteonecrosis of the femoral head. Results of core decompression and grafting with and without electrical stimulation. Clin Orthop Relat Res. 1989;249:199–208.
15.
Zurück zum Zitat Ercan B, Webster TJ. Greater osteoblast proliferation on anodized nanotubular titanium upon electrical stimulation. Int J Nanomed. 2008;3(4):477–85. Ercan B, Webster TJ. Greater osteoblast proliferation on anodized nanotubular titanium upon electrical stimulation. Int J Nanomed. 2008;3(4):477–85.
18.
Zurück zum Zitat Yamada A, Gaja N, Ohya S, Muraki K, Narita H, Ohwada T, et al. Usefulness and limitation of DiBAC4(3), a voltage-sensitive fluorescent dye, for the measurement of membrane potentials regulated by recombinant large conductance Ca2+-activated K+ channels in HEK293 cells. Jpn J Pharmacol. 2001;86(3):342–50.CrossRefPubMed Yamada A, Gaja N, Ohya S, Muraki K, Narita H, Ohwada T, et al. Usefulness and limitation of DiBAC4(3), a voltage-sensitive fluorescent dye, for the measurement of membrane potentials regulated by recombinant large conductance Ca2+-activated K+ channels in HEK293 cells. Jpn J Pharmacol. 2001;86(3):342–50.CrossRefPubMed
21.
Zurück zum Zitat Behari J. Effect of electrical stimulation in mineralization and collagen enrichment of osteoporotic rat bones. In: 2008 International conference on recent advances in microwave theory and applications 2008. Behari J. Effect of electrical stimulation in mineralization and collagen enrichment of osteoporotic rat bones. In: 2008 International conference on recent advances in microwave theory and applications 2008.
26.
Zurück zum Zitat Brochet F, Weber J. LinkedIn Corporation. Harvard Business School Case 112–006; 2012. Brochet F, Weber J. LinkedIn Corporation. Harvard Business School Case 112–006; 2012.
28.
Zurück zum Zitat Sharrard WJW. A double-blind trial of pulsed electromagnetic fields for delayed union of tibial fractures. J Bone Jt Surg Br. 1990;72:347–55.CrossRef Sharrard WJW. A double-blind trial of pulsed electromagnetic fields for delayed union of tibial fractures. J Bone Jt Surg Br. 1990;72:347–55.CrossRef
29.
Zurück zum Zitat Brighton CT. Treatment of non-union of the tibia with constant direct current. J Trauma. 1981;21:189–95.CrossRefPubMed Brighton CT. Treatment of non-union of the tibia with constant direct current. J Trauma. 1981;21:189–95.CrossRefPubMed
31.
Zurück zum Zitat Spadaro JA. Electrically stimulated bone growth in animals and man. Review of the literature. Clin Orthop Relat Res. 1977;122:325–32. Spadaro JA. Electrically stimulated bone growth in animals and man. Review of the literature. Clin Orthop Relat Res. 1977;122:325–32.
32.
Zurück zum Zitat Barker AT, Dixon RA, Sharrard WJW, Sutcliffe ML. Pulsed magnetic field therapy for tibial non-union. Interim results of a double-blind trial. Lancet. 1984;1:994–6.CrossRefPubMed Barker AT, Dixon RA, Sharrard WJW, Sutcliffe ML. Pulsed magnetic field therapy for tibial non-union. Interim results of a double-blind trial. Lancet. 1984;1:994–6.CrossRefPubMed
33.
Zurück zum Zitat Brighton C, Pollack S. Treatment of recalcitrant non-unions with a capacitively coupled electrical field. J Bone Joint Surg. 1985;67A:577–85.CrossRef Brighton C, Pollack S. Treatment of recalcitrant non-unions with a capacitively coupled electrical field. J Bone Joint Surg. 1985;67A:577–85.CrossRef
35.
Zurück zum Zitat EXOGEN. EXOGEN® Bone healing system shown to be most cost-effective bone stimulator. 2005. EXOGEN. EXOGEN® Bone healing system shown to be most cost-effective bone stimulator. 2005.
36.
Zurück zum Zitat Schultz M, Oremus M, Whitman C, Conway J. Cost-effectiveness of bone stimulators in the conservative treatment of stable nonunion fractures. Value Health. 2004;7:723 (International Society for Pharmacoeconomics and Outcomes Research (ISPOR)).CrossRef Schultz M, Oremus M, Whitman C, Conway J. Cost-effectiveness of bone stimulators in the conservative treatment of stable nonunion fractures. Value Health. 2004;7:723 (International Society for Pharmacoeconomics and Outcomes Research (ISPOR)).CrossRef
39.
Zurück zum Zitat Colson DJ, Browett JP, Fiddian NJ, Watson B. Treatment of delayed- and non-union of fractures using pulsed electromagnetic fields. J Biomed Eng. 1988;10:301–4.CrossRefPubMed Colson DJ, Browett JP, Fiddian NJ, Watson B. Treatment of delayed- and non-union of fractures using pulsed electromagnetic fields. J Biomed Eng. 1988;10:301–4.CrossRefPubMed
40.
Zurück zum Zitat Meril AJ. Direct current stimulation of allograft in anterior and posterior lumbar interbody fusions. Spine. 1994;19:2393–8.CrossRefPubMed Meril AJ. Direct current stimulation of allograft in anterior and posterior lumbar interbody fusions. Spine. 1994;19:2393–8.CrossRefPubMed
41.
Zurück zum Zitat Simmons JW, Hayes MA, Christensen DK, Dwyer AP, Koullsis CS, Kimmich SJ. The effect of postoperative pulsing electromagnetic fields on lumbar fusion: an open trial phase study. Quebec, Canada: Presented at the North American Spine Society; 1989. Simmons JW, Hayes MA, Christensen DK, Dwyer AP, Koullsis CS, Kimmich SJ. The effect of postoperative pulsing electromagnetic fields on lumbar fusion: an open trial phase study. Quebec, Canada: Presented at the North American Spine Society; 1989.
42.
Zurück zum Zitat Lee K. Clinical investigation of the spinal stem system open trial phase: pseudarthrosis stratum. Las Vegas, Nevada: Presented at the annual meeting of the American Academy of Orthopaedic Surgeons; 1989. Lee K. Clinical investigation of the spinal stem system open trial phase: pseudarthrosis stratum. Las Vegas, Nevada: Presented at the annual meeting of the American Academy of Orthopaedic Surgeons; 1989.
43.
Zurück zum Zitat Ebrahim S, Mollon B, Bance S, Busse JW, Bhandari M. Low-intensity pulsed ultrasonography versus electrical stimulation for fracture healing: a systematic review and network meta-analysis. Can J Surg. 2014;57(3):E105–18.CrossRefPubMedPubMedCentral Ebrahim S, Mollon B, Bance S, Busse JW, Bhandari M. Low-intensity pulsed ultrasonography versus electrical stimulation for fracture healing: a systematic review and network meta-analysis. Can J Surg. 2014;57(3):E105–18.CrossRefPubMedPubMedCentral
47.
48.
Zurück zum Zitat Buzza EP, Shibli JA, Barbeiro RH, Barbosa JR. Effects of electromagnetic field on bone healing around commercially pure titanium surface: histologic and mechanical study in rabbits. Implant Dent. 2003;12:182–7.CrossRefPubMed Buzza EP, Shibli JA, Barbeiro RH, Barbosa JR. Effects of electromagnetic field on bone healing around commercially pure titanium surface: histologic and mechanical study in rabbits. Implant Dent. 2003;12:182–7.CrossRefPubMed
49.
Zurück zum Zitat Fredericks DC, Piehl DJ, Baker JT, Abbott J, Nepola JV. Effects of pulsed electromagnetic field stimulation on distraction osteogenesis in the rabbit tibial leg lengthening model. J Pediatr Orthop. 2003;23:478–83.PubMed Fredericks DC, Piehl DJ, Baker JT, Abbott J, Nepola JV. Effects of pulsed electromagnetic field stimulation on distraction osteogenesis in the rabbit tibial leg lengthening model. J Pediatr Orthop. 2003;23:478–83.PubMed
50.
Zurück zum Zitat France JC, Norman TL, Santrock RD, McGrath B, Simon BJ. The efficacy of direct current stimulation for lumbar intertransverse process fusions in an animal model. Spine. 2001;26:1002–8.CrossRefPubMed France JC, Norman TL, Santrock RD, McGrath B, Simon BJ. The efficacy of direct current stimulation for lumbar intertransverse process fusions in an animal model. Spine. 2001;26:1002–8.CrossRefPubMed
54.
Zurück zum Zitat Matsumoto H, Ochi M, Abiko Y, Hirose Y, Kaku T, Sakaguchi K. Pulsed electromagnetic fields promote bone formation around dental implants inserted into the femur of rabbits. Clin Oral Implant Res. 2000;11(4):354–60.CrossRef Matsumoto H, Ochi M, Abiko Y, Hirose Y, Kaku T, Sakaguchi K. Pulsed electromagnetic fields promote bone formation around dental implants inserted into the femur of rabbits. Clin Oral Implant Res. 2000;11(4):354–60.CrossRef
55.
Zurück zum Zitat Ottani V, Raspanti M, Martini D, Tretola G, Ruggeri A, Franchi M, et al. Electromagnetic stimulation on the bone growth using backscattered electron imaging. Micron. 2002;33:121–5.CrossRefPubMed Ottani V, Raspanti M, Martini D, Tretola G, Ruggeri A, Franchi M, et al. Electromagnetic stimulation on the bone growth using backscattered electron imaging. Micron. 2002;33:121–5.CrossRefPubMed
56.
Zurück zum Zitat Rubinacci A, Black J, Brighton CT, Friedenberg ZB. Changes in bioelectric potentials on bone associated with direct current stimulation of osteogenesis. J Orthop Res. 1988;6:335–45.CrossRefPubMed Rubinacci A, Black J, Brighton CT, Friedenberg ZB. Changes in bioelectric potentials on bone associated with direct current stimulation of osteogenesis. J Orthop Res. 1988;6:335–45.CrossRefPubMed
57.
Zurück zum Zitat Shafer DM, Rogerson K, Norton L, Bennett J. The effect of electrical perturbation on osseointegration of titanium dental implants. J Oral Maxillofac Surg. 1995;53:1063–8.CrossRefPubMed Shafer DM, Rogerson K, Norton L, Bennett J. The effect of electrical perturbation on osseointegration of titanium dental implants. J Oral Maxillofac Surg. 1995;53:1063–8.CrossRefPubMed
58.
Zurück zum Zitat Shimizu E, Matsuda-Honjyo Y, Samoto H, Saito R, Nakajima Y, Nakayama Y, et al. Static magnetic fields-induced bone sialoprotein (BSP) expression is mediated through FGF2 response element and pituitary-specific transcription factor-1 motif. J Cell Biochem. 2004;91:1183–96.CrossRefPubMed Shimizu E, Matsuda-Honjyo Y, Samoto H, Saito R, Nakajima Y, Nakayama Y, et al. Static magnetic fields-induced bone sialoprotein (BSP) expression is mediated through FGF2 response element and pituitary-specific transcription factor-1 motif. J Cell Biochem. 2004;91:1183–96.CrossRefPubMed
59.
Zurück zum Zitat Smith R. Nagel D Effects of pulsing electromagnetic fields on bone growth and articular cartilage. Clin Orthop. 1983;181:277–82. Smith R. Nagel D Effects of pulsing electromagnetic fields on bone growth and articular cartilage. Clin Orthop. 1983;181:277–82.
60.
Zurück zum Zitat Taylor BC, French BG, Fowler TT, Russell J, Poka A. Induced membrane technique for reconstruction to manage bone loss. J Am Acad Orthop Surg. 2012;20:142–50.CrossRefPubMed Taylor BC, French BG, Fowler TT, Russell J, Poka A. Induced membrane technique for reconstruction to manage bone loss. J Am Acad Orthop Surg. 2012;20:142–50.CrossRefPubMed
61.
Zurück zum Zitat Veronesi F, Cadossi M, Giavaresi G, Martini L, Setti S, Buda R, et al. Pulsed electromagnetic fields combined with a collagenous scaffold and bone marrow concentrate enhance osteochondral regeneration: an in vivo study. BMC Musculoskelet Disord. 2015;2(16):233. https://doi.org/10.1186/s12891-015-0683-2.CrossRef Veronesi F, Cadossi M, Giavaresi G, Martini L, Setti S, Buda R, et al. Pulsed electromagnetic fields combined with a collagenous scaffold and bone marrow concentrate enhance osteochondral regeneration: an in vivo study. BMC Musculoskelet Disord. 2015;2(16):233. https://​doi.​org/​10.​1186/​s12891-015-0683-2.CrossRef
62.
Zurück zum Zitat Yonemori K, Matsunaga S, Ishidou Y, Maeda S, Yoshida H. Early effects of electrical stimulation on osteogenesis. Bone. 1996;19:173–80.CrossRefPubMed Yonemori K, Matsunaga S, Ishidou Y, Maeda S, Yoshida H. Early effects of electrical stimulation on osteogenesis. Bone. 1996;19:173–80.CrossRefPubMed
63.
Zurück zum Zitat Zimmerman M, Parsons JR, Alexander H, Weiss AB. The electrical stimulation of bone using a filamentous carbon cathode. J Biomed Mater Res. 1984;18:927–38.CrossRefPubMed Zimmerman M, Parsons JR, Alexander H, Weiss AB. The electrical stimulation of bone using a filamentous carbon cathode. J Biomed Mater Res. 1984;18:927–38.CrossRefPubMed
64.
Zurück zum Zitat Berry JL, Geiger JM, Moran JM, Skraba JS, Greenwald AS. Use of tricalcium phosphate or electrical-stimulation to enhance the bone porous implant interface. J Biomed Mater Res. 1986;20:65–77.CrossRefPubMed Berry JL, Geiger JM, Moran JM, Skraba JS, Greenwald AS. Use of tricalcium phosphate or electrical-stimulation to enhance the bone porous implant interface. J Biomed Mater Res. 1986;20:65–77.CrossRefPubMed
66.
Zurück zum Zitat Branham GB, Triplett RG, Yeandle S, Vieras F. The effect of electrical current on the healing of mandibular freeze-dried bone allografts in dogs. J Oral Maxillofac Surg. 1985;43(6):403–7.CrossRefPubMed Branham GB, Triplett RG, Yeandle S, Vieras F. The effect of electrical current on the healing of mandibular freeze-dried bone allografts in dogs. J Oral Maxillofac Surg. 1985;43(6):403–7.CrossRefPubMed
67.
Zurück zum Zitat Chakkalakal DA, Lippiello L, Shindell RL, Connolly JF. Electrophysiology of direct current stimulation of fracture healing in canine radius. IEEE Trans Biomed Eng. 1990;37:1048–58.CrossRefPubMed Chakkalakal DA, Lippiello L, Shindell RL, Connolly JF. Electrophysiology of direct current stimulation of fracture healing in canine radius. IEEE Trans Biomed Eng. 1990;37:1048–58.CrossRefPubMed
68.
Zurück zum Zitat Colella SM, Miller AG, Stang RG, Stoebe TG, Spengler DM. Fixation of porous titanium implants in cortical bone enhanced by electrical stimulation. J Biomed Mater Res. 1981;15:37–46.CrossRefPubMed Colella SM, Miller AG, Stang RG, Stoebe TG, Spengler DM. Fixation of porous titanium implants in cortical bone enhanced by electrical stimulation. J Biomed Mater Res. 1981;15:37–46.CrossRefPubMed
69.
Zurück zum Zitat Connolly JF, Henry H, Jardon J. The Electrical Enhancement of Periosteal Proliferation in Normal and Delayed Fracture Healing. Clin Orthop. 1977;124:97–105. Connolly JF, Henry H, Jardon J. The Electrical Enhancement of Periosteal Proliferation in Normal and Delayed Fracture Healing. Clin Orthop. 1977;124:97–105.
70.
Zurück zum Zitat Dejardin LM, Kahanovitz N, Arnoczky SP, Simon BJ. The effect of varied electrical current densities on lumbar spinal fusions in dogs. Spine J. 2001;1:341–7.CrossRefPubMed Dejardin LM, Kahanovitz N, Arnoczky SP, Simon BJ. The effect of varied electrical current densities on lumbar spinal fusions in dogs. Spine J. 2001;1:341–7.CrossRefPubMed
71.
Zurück zum Zitat Doyle ND. Rehabilitation of fractures in small animals: maximize outcomes, minimize complications. Clin Tech Small Anim Pract. 2004;19:180–91.CrossRefPubMed Doyle ND. Rehabilitation of fractures in small animals: maximize outcomes, minimize complications. Clin Tech Small Anim Pract. 2004;19:180–91.CrossRefPubMed
72.
Zurück zum Zitat Rodriguez Fuentes AE, Marcondes de Souza JP, Valeri V, Mascarenhas S. Experimental model of electric stimulation of pseudarthrosis healing. Clin Orthop. 1984;183:267–75. Rodriguez Fuentes AE, Marcondes de Souza JP, Valeri V, Mascarenhas S. Experimental model of electric stimulation of pseudarthrosis healing. Clin Orthop. 1984;183:267–75.
73.
Zurück zum Zitat Inoue N, Ohnishi I, Chen D, Deitz LW, Schwardt JD, Chao EYS. Effect of pulsed electromagnetic fields (PEMF) on late-phase osteotomy gap healing in a canine tibial model. J Orthop Res. 2002;20:1106–14.CrossRefPubMed Inoue N, Ohnishi I, Chen D, Deitz LW, Schwardt JD, Chao EYS. Effect of pulsed electromagnetic fields (PEMF) on late-phase osteotomy gap healing in a canine tibial model. J Orthop Res. 2002;20:1106–14.CrossRefPubMed
74.
Zurück zum Zitat Jacobs JD, Norton LA. Electrical stimulation of osteogenesis in periodontal defects. Clin Orthop. 1977;124:41–52. Jacobs JD, Norton LA. Electrical stimulation of osteogenesis in periodontal defects. Clin Orthop. 1977;124:41–52.
75.
Zurück zum Zitat Jacobs RR, Luethi U, Dueland RT, Perren SM. Electrical stimulation of experimental nonunions. Clin Orthop Relat Res. 1981;161:146–53. Jacobs RR, Luethi U, Dueland RT, Perren SM. Electrical stimulation of experimental nonunions. Clin Orthop Relat Res. 1981;161:146–53.
76.
Zurück zum Zitat Kahanovitz N, Arnoczky S, Nemzek J, Shores A. The effect of EMF pulsing on posterior lumbar spinal fusion in dogs. Spine. 1994;19:705–9.CrossRefPubMed Kahanovitz N, Arnoczky S, Nemzek J, Shores A. The effect of EMF pulsing on posterior lumbar spinal fusion in dogs. Spine. 1994;19:705–9.CrossRefPubMed
77.
Zurück zum Zitat Lindsey RW, Grobman J, Leggon RE, Panjabi M, Friedlaender GE. Effects of bone graft and electrical stimulation on the strength of healing bony defects in dogs. Clin Orthop. 1987;222:275–80. Lindsey RW, Grobman J, Leggon RE, Panjabi M, Friedlaender GE. Effects of bone graft and electrical stimulation on the strength of healing bony defects in dogs. Clin Orthop. 1987;222:275–80.
79.
Zurück zum Zitat Ortman LF, Casey DM, Deers M. Bioelectric stimulation and residual ridge resorption. J Prosthet Dent. 1992;67:67–71.CrossRefPubMed Ortman LF, Casey DM, Deers M. Bioelectric stimulation and residual ridge resorption. J Prosthet Dent. 1992;67:67–71.CrossRefPubMed
80.
Zurück zum Zitat Dev MED, Org ART, Ingrowth T, Recum V, Al PET. ABSTRACT The effect of electrical stimulation on the interfacial strength of the porous polymethylmethacrylate implant/oral tissue union and the amount. Department of Interdisciplinary Studies, College of Engineering Clemson University Clemson, 1978;6:291–303. Dev MED, Org ART, Ingrowth T, Recum V, Al PET. ABSTRACT The effect of electrical stimulation on the interfacial strength of the porous polymethylmethacrylate implant/oral tissue union and the amount. Department of Interdisciplinary Studies, College of Engineering Clemson University Clemson, 1978;6:291–303.
81.
Zurück zum Zitat Cundy PJ, Paterson DC. A ten year review of treatment of delayed union and nonunion with an implanted bone growth stimulator. Clin Orthop Relat Res. 1988;259:216–22. Cundy PJ, Paterson DC. A ten year review of treatment of delayed union and nonunion with an implanted bone growth stimulator. Clin Orthop Relat Res. 1988;259:216–22.
82.
Zurück zum Zitat Paterson DC, Hillier TM, Carter RF, Ludbrook J, Maxwell GM, Savage JP. Experimental delayed union of the dog tibia and its use in assessing the effect of an electrical bone growth stimulator. Clin Orthop. 1977;128:340–50. Paterson DC, Hillier TM, Carter RF, Ludbrook J, Maxwell GM, Savage JP. Experimental delayed union of the dog tibia and its use in assessing the effect of an electrical bone growth stimulator. Clin Orthop. 1977;128:340–50.
83.
Zurück zum Zitat Paterson DC, Carter RF, Tilbury RF, Ludbrook J. Savage JP The effects of varying current levels of electrical stimulation. Clin Ortho Relat Res. 1982;169:303–12. Paterson DC, Carter RF, Tilbury RF, Ludbrook J. Savage JP The effects of varying current levels of electrical stimulation. Clin Ortho Relat Res. 1982;169:303–12.
84.
Zurück zum Zitat Pepper JR, Herbert MA, Anderson JR, Bobechko WP. Effect of capacitive coupled electrical stimulation on regenerate bone. J Orthop Res. 1996;14:296–302.CrossRefPubMed Pepper JR, Herbert MA, Anderson JR, Bobechko WP. Effect of capacitive coupled electrical stimulation on regenerate bone. J Orthop Res. 1996;14:296–302.CrossRefPubMed
85.
Zurück zum Zitat Schutzer SF, Jasty M, Bragdon CR, Harrigan TP, Harris WH. A double-blind study on the effects of a capacitively coupled electrical field on bone ingrowth into porous-surfaced canine total hip prosthesis. Clin Orthop Rel Res. 1990;260:297–304.CrossRef Schutzer SF, Jasty M, Bragdon CR, Harrigan TP, Harris WH. A double-blind study on the effects of a capacitively coupled electrical field on bone ingrowth into porous-surfaced canine total hip prosthesis. Clin Orthop Rel Res. 1990;260:297–304.CrossRef
86.
Zurück zum Zitat Shayesteh YS, Eslami B, Dehghan MM, Vaziri H, Alikhassi M, Mangoli A, et al. The effect of a constant electrical field on osseointegration after immediate implantation in dog mandibles: a preliminary study: basic science research. J Prosthodont. 2007;16:337–42.CrossRefPubMed Shayesteh YS, Eslami B, Dehghan MM, Vaziri H, Alikhassi M, Mangoli A, et al. The effect of a constant electrical field on osseointegration after immediate implantation in dog mandibles: a preliminary study: basic science research. J Prosthodont. 2007;16:337–42.CrossRefPubMed
87.
Zurück zum Zitat Shokry M. Preliminary study on the use of a silver oxide watch battery (1.5 V) for electrical enhancement of bone healing. Vet Res Commun. 1985;9:245–50.CrossRefPubMed Shokry M. Preliminary study on the use of a silver oxide watch battery (1.5 V) for electrical enhancement of bone healing. Vet Res Commun. 1985;9:245–50.CrossRefPubMed
88.
Zurück zum Zitat Srivastava KP, Lahiri V, Khare A. Chandra H Histomorphologic evidence of fracture healing after direct electrical stimulation in dogs. J Trauma. 1982;22(9):785–6.CrossRefPubMed Srivastava KP, Lahiri V, Khare A. Chandra H Histomorphologic evidence of fracture healing after direct electrical stimulation in dogs. J Trauma. 1982;22(9):785–6.CrossRefPubMed
90.
Zurück zum Zitat Brighton CT, Tadduni GT, Goll SR, Pollack SR. Treatment of denervation/disuse osteoporosis in the rat with a capacitively coupled electrical signal: effects on bone formation and bone resorption. J Orthop Res. 1988;6:676–84.CrossRefPubMed Brighton CT, Tadduni GT, Goll SR, Pollack SR. Treatment of denervation/disuse osteoporosis in the rat with a capacitively coupled electrical signal: effects on bone formation and bone resorption. J Orthop Res. 1988;6:676–84.CrossRefPubMed
91.
Zurück zum Zitat Giannunzio GA, Speerli RC, Guglielmotti MB. Electrical field effect on peri-implant osteogenesis: a histologic and histomorphometric study. Implant Dent. 2008;17:118–26.CrossRefPubMed Giannunzio GA, Speerli RC, Guglielmotti MB. Electrical field effect on peri-implant osteogenesis: a histologic and histomorphometric study. Implant Dent. 2008;17:118–26.CrossRefPubMed
92.
Zurück zum Zitat Guizzardi S, Silvestre M, Govoni P, Scandroglio R. Pulsed electromagnetic field stimulation on posterior spinal fusions: a histological study in rats. J Spinal Disord. 1994;7:36–40.CrossRefPubMed Guizzardi S, Silvestre M, Govoni P, Scandroglio R. Pulsed electromagnetic field stimulation on posterior spinal fusions: a histological study in rats. J Spinal Disord. 1994;7:36–40.CrossRefPubMed
94.
Zurück zum Zitat Lirani-Galvão APR, Bergamaschi CT, Silva OL, Lazaretti-Castro M. Electrical field stimulation improves bone mineral density in ovariectomized rats. Braz J Med Biol Res. 2006;39:1501–5.CrossRefPubMed Lirani-Galvão APR, Bergamaschi CT, Silva OL, Lazaretti-Castro M. Electrical field stimulation improves bone mineral density in ovariectomized rats. Braz J Med Biol Res. 2006;39:1501–5.CrossRefPubMed
96.
Zurück zum Zitat Marino AA, Cullen JM, Reichmanis M, Becker RO. Fracture healing in rats exposed to extremely low frequency electric fields. Clin Orthop 1979;145:239–44. Marino AA, Cullen JM, Reichmanis M, Becker RO. Fracture healing in rats exposed to extremely low frequency electric fields. Clin Orthop 1979;145:239–44.
98.
Zurück zum Zitat Nakajima M, Inoue M, Hojo T, Inoue N, Tanaka K, Takatori R, et al. Effect of electroacupuncture on the healing process of tibia fracture in a rat model: a randomised controlled trial. Acupunct Med. 2010;28:140–3.CrossRefPubMed Nakajima M, Inoue M, Hojo T, Inoue N, Tanaka K, Takatori R, et al. Effect of electroacupuncture on the healing process of tibia fracture in a rat model: a randomised controlled trial. Acupunct Med. 2010;28:140–3.CrossRefPubMed
101.
Zurück zum Zitat Spadaro JA, Becker RO. Function of implanted cathodes in electrode-induced bone growth. Med Biol Eng Comput. 1979;17:769–75.CrossRefPubMed Spadaro JA, Becker RO. Function of implanted cathodes in electrode-induced bone growth. Med Biol Eng Comput. 1979;17:769–75.CrossRefPubMed
102.
Zurück zum Zitat Takano-Yamamoto T, Kawakami M, Sakuda M. Effect of a pulsing electromagnetic field on demineralized bone-matrix-induced bone formation in a bony defect in the premaxilla of rats. J Dent Res. 1992;71:1920–5.CrossRefPubMed Takano-Yamamoto T, Kawakami M, Sakuda M. Effect of a pulsing electromagnetic field on demineralized bone-matrix-induced bone formation in a bony defect in the premaxilla of rats. J Dent Res. 1992;71:1920–5.CrossRefPubMed
104.
Zurück zum Zitat Uysal T, Amasyali M, Olmez H, Karslioglu Y, Gunhan O. Stimulation of bone formation by direct electrical current in an orthopedically expanded suture in the rat. Korean J Orthod. 2010;40:106–14.CrossRef Uysal T, Amasyali M, Olmez H, Karslioglu Y, Gunhan O. Stimulation of bone formation by direct electrical current in an orthopedically expanded suture in the rat. Korean J Orthod. 2010;40:106–14.CrossRef
111.
Zurück zum Zitat El-Hakim IE, Azim AM, El-Hassan MF, Maree SM. Preliminary investigation into the effects of electrical stimulation on mandibular distraction osteogenesis in goats. Int J Oral Maxillofac Surg. 2004;33(1):42–7.CrossRefPubMed El-Hakim IE, Azim AM, El-Hassan MF, Maree SM. Preliminary investigation into the effects of electrical stimulation on mandibular distraction osteogenesis in goats. Int J Oral Maxillofac Surg. 2004;33(1):42–7.CrossRefPubMed
112.
Zurück zum Zitat Law HT, Annan I, McCarthy ID, Hughes SP, Stead AC, Camburn MA, et al. The effect of induced electric currents on bone after experimental osteotomy in sheep. J Bone Jt Surg Br. 1985;67:463–9.CrossRef Law HT, Annan I, McCarthy ID, Hughes SP, Stead AC, Camburn MA, et al. The effect of induced electric currents on bone after experimental osteotomy in sheep. J Bone Jt Surg Br. 1985;67:463–9.CrossRef
114.
Zurück zum Zitat Toth JM, Seim HB, Schwardt JD, Humphrey WB, Wallskog JA, Turner AS. Direct current electrical stimulation increases the fusion rate of spinal fusion cages. Spine. 2000;25:2580–7.CrossRefPubMed Toth JM, Seim HB, Schwardt JD, Humphrey WB, Wallskog JA, Turner AS. Direct current electrical stimulation increases the fusion rate of spinal fusion cages. Spine. 2000;25:2580–7.CrossRefPubMed
115.
Zurück zum Zitat Canè V, Botti P, Farneti D, Soana S. Electromagnetic stimulation of bone repair: a histomorphometric study. J Orthop Res. 1991;9:908–17.CrossRefPubMed Canè V, Botti P, Farneti D, Soana S. Electromagnetic stimulation of bone repair: a histomorphometric study. J Orthop Res. 1991;9:908–17.CrossRefPubMed
116.
Zurück zum Zitat Kold SE, Hickman J. Preliminary study of quantitative aspects and the effect of pulsed electromagnetic field treatment on the incorporation of equine cancellous bone graft. Equine Vet J. 1987;19(2):120–4.CrossRefPubMed Kold SE, Hickman J. Preliminary study of quantitative aspects and the effect of pulsed electromagnetic field treatment on the incorporation of equine cancellous bone graft. Equine Vet J. 1987;19(2):120–4.CrossRefPubMed
117.
Zurück zum Zitat Sanders-Shamis M, Bramlage LR, Weisbrode SE, Gabel AA. A preliminary investigation of the effect of selected electromagnetic field devices on healing of cannon bone osteotomies in horses. Equine Vet J. 1989;21:201–5.CrossRefPubMed Sanders-Shamis M, Bramlage LR, Weisbrode SE, Gabel AA. A preliminary investigation of the effect of selected electromagnetic field devices on healing of cannon bone osteotomies in horses. Equine Vet J. 1989;21:201–5.CrossRefPubMed
118.
Zurück zum Zitat Abeed RI, Naseer M, Abel EW. Capacitively coupled electrical stimulation treatment: results from patients with failed long bone fracture unions. J Orthop Trauma. 1998;12:510–3.CrossRefPubMed Abeed RI, Naseer M, Abel EW. Capacitively coupled electrical stimulation treatment: results from patients with failed long bone fracture unions. J Orthop Trauma. 1998;12:510–3.CrossRefPubMed
120.
Zurück zum Zitat Andersen T, Christensen FB, Egund N, Ernst C, Fruensgaard S, Ostergaard J, et al. The effect of electrical stimulation on lumbar spinal fusion in older patients: a randomized, controlled, multi-center trial: part 2: fusion rates. Spine. 2009;34:2248–53.CrossRefPubMed Andersen T, Christensen FB, Egund N, Ernst C, Fruensgaard S, Ostergaard J, et al. The effect of electrical stimulation on lumbar spinal fusion in older patients: a randomized, controlled, multi-center trial: part 2: fusion rates. Spine. 2009;34:2248–53.CrossRefPubMed
123.
Zurück zum Zitat Bassett CA, Mitchell SN, Gaston SR. Treatment of ununited tibial diaphyseal fractures with pulsing electromagnetic fields. J Bone Jt Surg Am. 1981;63:511–23.CrossRef Bassett CA, Mitchell SN, Gaston SR. Treatment of ununited tibial diaphyseal fractures with pulsing electromagnetic fields. J Bone Jt Surg Am. 1981;63:511–23.CrossRef
124.
Zurück zum Zitat Beck BR, Matheson GO, Bergman G, Norling T, Fredericson M, Hoffman AR, et al. Do capacitively coupled electric fields accelerate tibial stress fracture healing? A randomized controlled trial. Am J Sports Med. 2008;36(3):545–53.CrossRefPubMed Beck BR, Matheson GO, Bergman G, Norling T, Fredericson M, Hoffman AR, et al. Do capacitively coupled electric fields accelerate tibial stress fracture healing? A randomized controlled trial. Am J Sports Med. 2008;36(3):545–53.CrossRefPubMed
125.
Zurück zum Zitat Benazzo F, Mosconi M, Beccarisi G, Galli U. Use of capacitive coupled electric fields in stress fractures in athletes. Clin Orthop Relat Res. 1995;310:145–9. Benazzo F, Mosconi M, Beccarisi G, Galli U. Use of capacitive coupled electric fields in stress fractures in athletes. Clin Orthop Relat Res. 1995;310:145–9.
127.
Zurück zum Zitat Bronner S, Novella T, Becica L. Management of a delayed-union sesamoid fracture in a dancer. J Orthop Sports Phys Ther. 2007;37:529–40.CrossRefPubMed Bronner S, Novella T, Becica L. Management of a delayed-union sesamoid fracture in a dancer. J Orthop Sports Phys Ther. 2007;37:529–40.CrossRefPubMed
128.
Zurück zum Zitat Capanna R, Donati D, Masetti C, Manfrini M, Panozzo A, Cadossi R, et al. Effect of electromagnetic fields on patients undergoing massive bone graft following bone tumor resection. A double blind study. Clin Orthop Rel Res. 1994;306:213–21. Capanna R, Donati D, Masetti C, Manfrini M, Panozzo A, Cadossi R, et al. Effect of electromagnetic fields on patients undergoing massive bone graft following bone tumor resection. A double blind study. Clin Orthop Rel Res. 1994;306:213–21.
129.
Zurück zum Zitat de Haas WG, Watson J, Morrison DM. Non-invasive treatment of ununited fractures of the tibia using electrical stimulation. J Bone Jt Surg Br. 1980;62:465–70.CrossRef de Haas WG, Watson J, Morrison DM. Non-invasive treatment of ununited fractures of the tibia using electrical stimulation. J Bone Jt Surg Br. 1980;62:465–70.CrossRef
130.
Zurück zum Zitat Donley BG, Ward DM. Implantable electrical stimulation in high-risk hindfoot fusions. Foot Ankle Int. 2002;23:13–8.CrossRefPubMed Donley BG, Ward DM. Implantable electrical stimulation in high-risk hindfoot fusions. Foot Ankle Int. 2002;23:13–8.CrossRefPubMed
131.
Zurück zum Zitat Dunn A, Rush G. Electrical stimulation in treatment of delayed union and nonunion of fractures and osteotomies. South Med J. 1984;77:1530–4.CrossRefPubMed Dunn A, Rush G. Electrical stimulation in treatment of delayed union and nonunion of fractures and osteotomies. South Med J. 1984;77:1530–4.CrossRefPubMed
132.
Zurück zum Zitat Foley K, Mroz T, Arnold P. Randomized, prospective, and controlled clinical trial of pulsed electromagnetic field stimulation for cervical fusion. Spine J. 2008;8:436–42.CrossRefPubMed Foley K, Mroz T, Arnold P. Randomized, prospective, and controlled clinical trial of pulsed electromagnetic field stimulation for cervical fusion. Spine J. 2008;8:436–42.CrossRefPubMed
133.
Zurück zum Zitat Fourie JA, Bowerbank P. Stimulation of bone healing in new fractures of the tibial shaft using interferential currents. Physiother Res Int. 1997;2:255–68.CrossRefPubMed Fourie JA, Bowerbank P. Stimulation of bone healing in new fractures of the tibial shaft using interferential currents. Physiother Res Int. 1997;2:255–68.CrossRefPubMed
134.
Zurück zum Zitat Freedman LS. Pulsating electromagnetic fields in the treatment of delayed and non-union of fractures: results from a district general hospital. Injury. 1985;16:315–7.CrossRefPubMed Freedman LS. Pulsating electromagnetic fields in the treatment of delayed and non-union of fractures: results from a district general hospital. Injury. 1985;16:315–7.CrossRefPubMed
135.
Zurück zum Zitat Garland D, Holt P, Harrington JT, Caldwell J, Zizic T, Cholewczynski J. A 3-month, randomized, double-blind, placebo-controlled study to evaluate the safety and efficacy of a highly optimized, capacitively coupled, pulsed electrical stimulator in patients with osteoarthritis of the knee. Osteoarthr Cartil. 2007;15(6):630–7.CrossRef Garland D, Holt P, Harrington JT, Caldwell J, Zizic T, Cholewczynski J. A 3-month, randomized, double-blind, placebo-controlled study to evaluate the safety and efficacy of a highly optimized, capacitively coupled, pulsed electrical stimulator in patients with osteoarthritis of the knee. Osteoarthr Cartil. 2007;15(6):630–7.CrossRef
136.
Zurück zum Zitat Goodwin C, Brighton C, Guyer R, Johnson J, Light K, Yuan H. A double blind study of capacitively coupled electrical stimulation as an adjunct to lumbar spinal fusion. Spine. 1999;24:1349–57.CrossRefPubMed Goodwin C, Brighton C, Guyer R, Johnson J, Light K, Yuan H. A double blind study of capacitively coupled electrical stimulation as an adjunct to lumbar spinal fusion. Spine. 1999;24:1349–57.CrossRefPubMed
137.
Zurück zum Zitat Hanft JR, Goggin JP, Landsman A, Surprenant M. The role of combined magnetic field bone growth stimulation as an adjunct in the treatment of neuroarthropathy/Charcot joint: an expanded pilot study. J Foot Ankle Surg. 1998;37:510–5.CrossRefPubMed Hanft JR, Goggin JP, Landsman A, Surprenant M. The role of combined magnetic field bone growth stimulation as an adjunct in the treatment of neuroarthropathy/Charcot joint: an expanded pilot study. J Foot Ankle Surg. 1998;37:510–5.CrossRefPubMed
139.
Zurück zum Zitat Hannemann PFW, Göttgens KWA, van Wely BJ, Kolkman KA, Werre AJ, Poeze M, et al. The clinical and radiological outcome of pulsed electromagnetic field treatment for acute scaphoid fractures: a randomised double-blind placebo-controlled multicentre trial. J Bone Jt Surg Br. 2012;94(10):1403–8.CrossRef Hannemann PFW, Göttgens KWA, van Wely BJ, Kolkman KA, Werre AJ, Poeze M, et al. The clinical and radiological outcome of pulsed electromagnetic field treatment for acute scaphoid fractures: a randomised double-blind placebo-controlled multicentre trial. J Bone Jt Surg Br. 2012;94(10):1403–8.CrossRef
140.
Zurück zum Zitat Holmes GB. Treatment of delayed unions and nonunions of the proximal fifth metatarsal with pulsed electromagnetic fields. Foot Ankle Int. 1994;15:552–6.CrossRefPubMed Holmes GB. Treatment of delayed unions and nonunions of the proximal fifth metatarsal with pulsed electromagnetic fields. Foot Ankle Int. 1994;15:552–6.CrossRefPubMed
141.
Zurück zum Zitat Ito H, Shirai Y. The efficacy of ununited tibial fracture treatment using pulsing electromagnetic fields: relation to biological activity on nonunion bone ends. J Nippon Med Sch. 2001;68(2):149–53.CrossRefPubMed Ito H, Shirai Y. The efficacy of ununited tibial fracture treatment using pulsing electromagnetic fields: relation to biological activity on nonunion bone ends. J Nippon Med Sch. 2001;68(2):149–53.CrossRefPubMed
143.
Zurück zum Zitat Jenis L, Howard S, Rebecca S, Brett Y. Prospective comparison of the effect of direct current electrical stimulation and pulsed electromagnetic fields on instrumented posteolateral lumbar arthrodesis. Spinal Disord. 2000;13:290–6.CrossRef Jenis L, Howard S, Rebecca S, Brett Y. Prospective comparison of the effect of direct current electrical stimulation and pulsed electromagnetic fields on instrumented posteolateral lumbar arthrodesis. Spinal Disord. 2000;13:290–6.CrossRef
144.
Zurück zum Zitat Jorgensen TE. Electrical stimulation of human fracture healing by means of a slow pulsating, asymmetrical direct current. Clin Orthop Rel R. 1977;124:127. Jorgensen TE. Electrical stimulation of human fracture healing by means of a slow pulsating, asymmetrical direct current. Clin Orthop Rel R. 1977;124:127.
145.
Zurück zum Zitat Kahn J. Transcutaneous electrical nerve stimulation for nonunited fractures; a clinical report. Phys Ther. 1982;62:840–4.CrossRefPubMed Kahn J. Transcutaneous electrical nerve stimulation for nonunited fractures; a clinical report. Phys Ther. 1982;62:840–4.CrossRefPubMed
146.
Zurück zum Zitat Kane WJ. Direct current electrical bone growth stimulation for spinal fusion. Spine. 1988;13:363–5.CrossRefPubMed Kane WJ. Direct current electrical bone growth stimulation for spinal fusion. Spine. 1988;13:363–5.CrossRefPubMed
147.
Zurück zum Zitat Kucharzyk D. A controlled prospective outcome study of implantable electrical stimulation with spinal instrumentation in a high risk spinal fusion population. Spine. 1999;24:465–68.CrossRefPubMed Kucharzyk D. A controlled prospective outcome study of implantable electrical stimulation with spinal instrumentation in a high risk spinal fusion population. Spine. 1999;24:465–68.CrossRefPubMed
148.
Zurück zum Zitat Lazovic M, Kocic M, Dimitrijevic L, Stankovic I, Spalevic M, Ciric T. Pulsed electromagnetic field during cast immobilization in postmenopausal women with Colles’ fracture. Srp Arh Celok Lek. 2012;140(9–10):619–24.CrossRefPubMed Lazovic M, Kocic M, Dimitrijevic L, Stankovic I, Spalevic M, Ciric T. Pulsed electromagnetic field during cast immobilization in postmenopausal women with Colles’ fracture. Srp Arh Celok Lek. 2012;140(9–10):619–24.CrossRefPubMed
149.
Zurück zum Zitat Linovitz R, Pathria M, Bernhardt M, Green D, Law M, McGuire R, et al. Combined magnetic fields accelerate and increase spine fusion: a double-blind, randomized, placebo controlled study. Spine. 2002;27:1383–9.CrossRefPubMed Linovitz R, Pathria M, Bernhardt M, Green D, Law M, McGuire R, et al. Combined magnetic fields accelerate and increase spine fusion: a double-blind, randomized, placebo controlled study. Spine. 2002;27:1383–9.CrossRefPubMed
150.
Zurück zum Zitat Livesley PJ, Mugglestone A, Whitton J. Electrotherapy and the management of minimally displaced fracture of the neck of the humerus. Injury. 1992;23:323–6.CrossRefPubMed Livesley PJ, Mugglestone A, Whitton J. Electrotherapy and the management of minimally displaced fracture of the neck of the humerus. Injury. 1992;23:323–6.CrossRefPubMed
151.
Zurück zum Zitat Madronero A, Pitillas I, Manso FJ. Pulsed electromagnetic field treatment failure in radius non-united fracture healing. J Biomed Eng. 1988;10:463–6.CrossRefPubMed Madronero A, Pitillas I, Manso FJ. Pulsed electromagnetic field treatment failure in radius non-united fracture healing. J Biomed Eng. 1988;10:463–6.CrossRefPubMed
152.
Zurück zum Zitat Mammi GI, Rocchi R, Cadossi R, et al. The electrical stimulation of tibial osteotomies: A double-blind study. Clin Orthop. 1993;288:246–53. Mammi GI, Rocchi R, Cadossi R, et al. The electrical stimulation of tibial osteotomies: A double-blind study. Clin Orthop. 1993;288:246–53.
153.
Zurück zum Zitat Marks RA. Spine fusion for discogenic low back pain: outcomes in patients treated with or without pulsed electromagnetic field stimulation. Adv Ther. 2000;17:57–67.CrossRefPubMed Marks RA. Spine fusion for discogenic low back pain: outcomes in patients treated with or without pulsed electromagnetic field stimulation. Adv Ther. 2000;17:57–67.CrossRefPubMed
154.
Zurück zum Zitat Martinez-Rondanelli A, Martinez JP, Moncada ME, Manzi E, Pinedo CR, Cadavid H. Electromagnetic stimulation as coadjuvant in the healing of diaphyseal femoral fractures: a randomized controlled trial. Colomb Med (Cali). 2014;45(2):67–71.CrossRef Martinez-Rondanelli A, Martinez JP, Moncada ME, Manzi E, Pinedo CR, Cadavid H. Electromagnetic stimulation as coadjuvant in the healing of diaphyseal femoral fractures: a randomized controlled trial. Colomb Med (Cali). 2014;45(2):67–71.CrossRef
155.
Zurück zum Zitat Massari L, Fini M, Cadossi R. Biophysical stimulation with pulsed electromagnetic fields in osteonecrosis of the femoral head. J Bone Jt Surg Am. 2006;88:56–60. Massari L, Fini M, Cadossi R. Biophysical stimulation with pulsed electromagnetic fields in osteonecrosis of the femoral head. J Bone Jt Surg Am. 2006;88:56–60.
156.
Zurück zum Zitat Masureik C, Eriksson C. Preliminary clinical evaluation of the effect of small electrical currents on the healing of jaw fractures. Clin Orthop Relat R. 1977;124:84–91. Masureik C, Eriksson C. Preliminary clinical evaluation of the effect of small electrical currents on the healing of jaw fractures. Clin Orthop Relat R. 1977;124:84–91.
157.
Zurück zum Zitat Meskens M, Stuyck J, Mulier J. Treatment of delayed union and nonunion of the tibia by pulsed electromagnetic fields. Bull Hosp Jt Dis Orthop Inst. 1988;48:170–5.PubMed Meskens M, Stuyck J, Mulier J. Treatment of delayed union and nonunion of the tibia by pulsed electromagnetic fields. Bull Hosp Jt Dis Orthop Inst. 1988;48:170–5.PubMed
158.
Zurück zum Zitat Paterson D, Simonis RB. Electrical stimulation in the treatment of congenital pseudoarthrosis of the tibia. J Bone Jt Surg Br. 1985;67:454–62.CrossRef Paterson D, Simonis RB. Electrical stimulation in the treatment of congenital pseudoarthrosis of the tibia. J Bone Jt Surg Br. 1985;67:454–62.CrossRef
159.
Zurück zum Zitat Punt BJ, Den Hoed PT, Fontijne WPJ. Pulsed electromagnetic fields in the treatment of nonunion. Eur J Orthop Surg Traumatol. 2008;18:127–33.CrossRef Punt BJ, Den Hoed PT, Fontijne WPJ. Pulsed electromagnetic fields in the treatment of nonunion. Eur J Orthop Surg Traumatol. 2008;18:127–33.CrossRef
160.
Zurück zum Zitat Reilingh ML, van Bergen CJA, Gerards RM, van Eekeren IC, de Haan RJ, Sierevelt IN, et al. Effects of pulsed electromagnetic fields on return to sports after arthroscopic debridement and microfracture of osteochondral talar defects: a randomized, double-blind, placebo-controlled, multicenter trial. Am J Sports Med. 2016;44(5):1292–300. https://doi.org/10.1177/0363546515626544.CrossRefPubMed Reilingh ML, van Bergen CJA, Gerards RM, van Eekeren IC, de Haan RJ, Sierevelt IN, et al. Effects of pulsed electromagnetic fields on return to sports after arthroscopic debridement and microfracture of osteochondral talar defects: a randomized, double-blind, placebo-controlled, multicenter trial. Am J Sports Med. 2016;44(5):1292–300. https://​doi.​org/​10.​1177/​0363546515626544​.CrossRefPubMed
161.
Zurück zum Zitat Rogozinski A, Rogozinski C. Efficacy of implanted bone growth stimulation in instrumented lumbosacral spinal fusion. Spine. 1996;21:2479–483.CrossRefPubMed Rogozinski A, Rogozinski C. Efficacy of implanted bone growth stimulation in instrumented lumbosacral spinal fusion. Spine. 1996;21:2479–483.CrossRefPubMed
162.
Zurück zum Zitat Saltzman C, Lightfoot A, Amendola A. PEMF as treatment for delayed healing of foot and ankle arthrodesis. Foot Ankle Int. 2004;25:771–3.CrossRefPubMed Saltzman C, Lightfoot A, Amendola A. PEMF as treatment for delayed healing of foot and ankle arthrodesis. Foot Ankle Int. 2004;25:771–3.CrossRefPubMed
163.
Zurück zum Zitat Scott G, King JB. A prospective, double-blind trial of electrical capacitive coupling in the treatment of non-union of long bones. J Bone Jt Surg Am. 1994;76:820–6.CrossRef Scott G, King JB. A prospective, double-blind trial of electrical capacitive coupling in the treatment of non-union of long bones. J Bone Jt Surg Am. 1994;76:820–6.CrossRef
165.
Zurück zum Zitat Simmons JW. Treatment of failed posterior lumbar interbody fusion (PLIF) of the spine with pulsing electromagnetic fields. Clin Orthop Relat Res. 1985;183:127. Simmons JW. Treatment of failed posterior lumbar interbody fusion (PLIF) of the spine with pulsing electromagnetic fields. Clin Orthop Relat Res. 1985;183:127.
166.
Zurück zum Zitat Simmons JW, Mooney V, Thacker I. Pseudarthrosis after lumbar spine fusion: nonoperative salvage with pulsed electromagnetic fields. Am J Orthop. 2004;33:27–30.PubMed Simmons JW, Mooney V, Thacker I. Pseudarthrosis after lumbar spine fusion: nonoperative salvage with pulsed electromagnetic fields. Am J Orthop. 2004;33:27–30.PubMed
167.
Zurück zum Zitat Streit A, Watson BC, Granata JD, Philbin TM, Lin H-N, O’Connor JP, et al. Effect on clinical outcome and growth factor synthesis with adjunctive use of pulsed electromagnetic fields for fifth metatarsal nonunion fracture: a double-blind randomized study. Foot Ankle Int. 2016;37(9):919–23. https://doi.org/10.1177/1071100716652621.CrossRefPubMed Streit A, Watson BC, Granata JD, Philbin TM, Lin H-N, O’Connor JP, et al. Effect on clinical outcome and growth factor synthesis with adjunctive use of pulsed electromagnetic fields for fifth metatarsal nonunion fracture: a double-blind randomized study. Foot Ankle Int. 2016;37(9):919–23. https://​doi.​org/​10.​1177/​1071100716652621​.CrossRefPubMed
168.
Zurück zum Zitat Steinberg ME, Brighton CT, Bands RE, Hartman KM. Capacitive coupling as an adjunctive treatment for avascular necrosis. Clin Orthop Relat Res. 1990;261:11–8. Steinberg ME, Brighton CT, Bands RE, Hartman KM. Capacitive coupling as an adjunctive treatment for avascular necrosis. Clin Orthop Relat Res. 1990;261:11–8.
170.
Zurück zum Zitat Wahlstrom O, Knutsson H. A device for generation of electromagnetic fields of extremely low frequency. J Biomed Eng. 1984;6:293–6.CrossRefPubMed Wahlstrom O, Knutsson H. A device for generation of electromagnetic fields of extremely low frequency. J Biomed Eng. 1984;6:293–6.CrossRefPubMed
171.
Zurück zum Zitat Welch WC, Willis SL, Gerszten PC. Implantable direct current stimulation in para-axial cervical arthrodesis. Adv Ther. 2004;21:389–400.CrossRefPubMed Welch WC, Willis SL, Gerszten PC. Implantable direct current stimulation in para-axial cervical arthrodesis. Adv Ther. 2004;21:389–400.CrossRefPubMed
Metadaten
Titel
Electrical stimulation-based bone fracture treatment, if it works so well why do not more surgeons use it?
verfasst von
Mit Balvantray Bhavsar
Zhihua Han
Thomas DeCoster
Liudmila Leppik
Karla Mychellyne Costa Oliveira
John H Barker
Publikationsdatum
06.04.2019
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Trauma and Emergency Surgery / Ausgabe 2/2020
Print ISSN: 1863-9933
Elektronische ISSN: 1863-9941
DOI
https://doi.org/10.1007/s00068-019-01127-z

Arthropedia

Grundlagenwissen der Arthroskopie und Gelenkchirurgie erweitert durch Fallbeispiele, Videos und Abbildungen. Zur Fortbildung und Wissenserweiterung, verfasst und geprüft von Expertinnen und Experten der Gesellschaft für Arthroskopie und Gelenkchirurgie (AGA).


Jetzt entdecken!

Neu im Fachgebiet Orthopädie und Unfallchirurgie

Nackenschmerzen nach Bandscheibenvorfall: Muskeltraining hilft!

Bei hartnäckigen Schmerzen aufgrund einer zervikalen Radikulopathie schlägt ein Team der Universität Istanbul vor, lokale Steroidinjektionen mit einem speziellen Trainingsprogramm zur Stabilisierung der Nackenmuskulatur zu kombinieren.

Die elektronische Patientenakte kommt: Das sollten Sie jetzt wissen

Am 15. Januar geht die „ePA für alle“ zunächst in den Modellregionen an den Start. Doch schon bald soll sie in allen Praxen zum Einsatz kommen. Was ist jetzt zu tun? Was müssen Sie wissen? Wir geben in einem FAQ Antworten auf 21 Fragen.

Was sich Menschen mit Frozen Shoulder wünschen

Die Capsulitis adhaesiva des Glenohumeralgelenks, auch als Frozen Shoulder bezeichnet, belastet die Betroffenen weit über die körperlichen Beschwerden hinaus, wie eine italienische Studie ergeben hat.

Restriktive Sauerstoffgabe ohne Vorteil bei schwerem Trauma

Ob schwer verletzte Personen besser restriktiv oder liberal mit Sauerstoff versorgt werden sollten, hat die Arbeitsgruppe der TRAUMOX2-Studie untersucht – mit klarem Ergebnis.

Update Orthopädie und Unfallchirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.