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03.01.2020 | Clinical Case Report

Electroretinographic abnormalities associated with pregabalin: a case report

verfasst von: Wakana Ninomiya, Kei Mizobuchi, Takaaki Hayashi, Sachiyo Okude, Satoshi Katagiri, Akiko Kubo, Nami Masuhara, Tadashi Nakano

Erschienen in: Documenta Ophthalmologica | Ausgabe 3/2020

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Abstract

Purpose

Pregabalin binds to the α2–δ1/α2–δ2 subunits of the voltage-gated L-type calcium channel (LTCC), which is expressed in rod/cone photoreceptor terminals. The purpose of this report was to describe electroretinographic abnormalities associated with pregabalin treatment.

Case presentation

This is an observational case report. A 49-year-old female reported photophobia and night blindness in her left eye after 10 months of pregabalin administration. One month after the symptoms, ophthalmic examinations were performed, which revealed good visual acuity and no remarkable fundus findings. However, full-field electroretinography (ERG) of the left eye revealed a decreased b-wave in rod ERG, a slightly decreased a-wave and severely decreased b-wave (negative ERG) in bright flash ERG, decreased a- and b-waves in cone ERG, and decreased b-waves in 30-Hz flicker ERG. These findings are similar to those seen in incomplete congenital stationary night blindness, whereas the right eye ERG showed normal responses, except for a square a-wave in cone ERG. The ERG gradually improved from 1 to 12 months after discontinuing pregabalin. Finally, b-waves in bright flash ERG and cone ERG responses largely recovered, but b-waves in rod ERG and a-waves in bright flash ERG only partially recovered in the left eye. The square a-wave recovered to normal in the right eye.

Conclusions

This is the first report to indicate that ERG abnormalities might be associated with pregabalin treatment. Our results suggest that pregabalin may affect LTCC function via the α2–δ1/α2–δ2 subunits, which leads to defective synaptic transmission from rod/cone photoreceptors to bipolar cells.

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Titel: Electroretinographic abnormalities associated with pregabalin: a case report
verfasst von: Wakana Ninomiya
Kei Mizobuchi
Takaaki Hayashi
Sachiyo Okude
Satoshi Katagiri
Akiko Kubo
Nami Masuhara
Tadashi Nakano
Publikationsdatum: 03.01.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: Documenta Ophthalmologica / Ausgabe 3/2020
Print ISSN: 0012-4486
Elektronische ISSN: 1573-2622
DOI: https://doi.org/10.1007/s10633-019-09743-1

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Electroretinographic abnormalities associated with pregabalin: a case report

Abstract

Purpose

Case presentation

Conclusions

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Springer Medizin

Abstract

Purpose

Case presentation

Conclusions

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