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Metabolic Brain Disease

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01.12.2014 | Research Article

Elevated cerebral lactate: Implications in the pathogenesis of hepatic encephalopathy

verfasst von: Cristina R. Bosoi, Christopher F. Rose

Erschienen in: Metabolic Brain Disease | Ausgabe 4/2014

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Abstract

Hepatic encephalopathy (HE), a complex neuropsychiatric syndrome, is a frequent complication of liver failure/disease. Increased concentrations of lactate are commonly observed in HE patients, in the systemic circulation, but also in the brain. Traditionally, increased cerebral lactate is considered a marker of energy failure/impairment however alterations in lactate homeostasis may also lead to a rise in brain lactate and result in neuronal dysfunction. The latter may involve the development of brain edema. This review will target the significance of increased cerebral lactate in the pathogenesis of HE.

Throughout the text, “lactate” will represent L-lactate.

Throughout the text, “LDH” will represent L-LDH.

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Titel: Elevated cerebral lactate: Implications in the pathogenesis of hepatic encephalopathy
verfasst von: Cristina R. Bosoi
Christopher F. Rose
Publikationsdatum: 01.12.2014
Verlag: Springer US
Erschienen in: Metabolic Brain Disease / Ausgabe 4/2014
Print ISSN: 0885-7490
Elektronische ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-014-9573-9

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Elevated cerebral lactate: Implications in the pathogenesis of hepatic encephalopathy

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