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Erschienen in: Inflammation 1/2015

01.02.2015

Elevated Expression of NLRP1 and IPAF Are Related to Oral Pemphigus Vulgaris Pathogenesis

verfasst von: Reza Mahvelati Shamsabadi, Soroush Basafa, Reza Yarahmadi, Samaneh Goorani, Masood Khani, Maryam Kamarehei, Amir Hossein Kiani

Erschienen in: Inflammation | Ausgabe 1/2015

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Abstract

Oral pemphigus vulgaris (PV) is a rare blistering disorder of the skin and mucous membranes in the mouth. Inflammasome serves as a molecular platform that mediates the autoactivation of caspase-1, which cleaves the pro-forms of IL-1β and IL-18 to active forms. Therefore, the main aim of this study was to evaluate the messenger RNA (mRNA) levels of NOD-like receptor-related protein (NLRP)1, NLRP3, and IPAF in the PBMCs of PV patients to determine their effect in PV pathogenesis. This study was designed as a cross-sectional study. We studied mRNA levels of three types of inflammasomes including NLRP1, NLRP3, and IPAF in 43 oral PV patients and 40 healthy controls by real-time PCR technique. Results were analyzed by SPSS software package version 18. Here, we showed that the mRNA levels of NLRP1 and IPAF in patients with active PV remarkably increased compared to those in healthy controls. However, the mRNA level of NLRP3 in PBMC of PV patients was similar to that of the control group. We showed important and emerging relationship of NLRP1 and IPAF mRNAs with PV disease progression. We hypothesize that NLRP1 and IPAF with cytokine activity of IL-1β are involved in the inflammation in PV patients.
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Metadaten
Titel
Elevated Expression of NLRP1 and IPAF Are Related to Oral Pemphigus Vulgaris Pathogenesis
verfasst von
Reza Mahvelati Shamsabadi
Soroush Basafa
Reza Yarahmadi
Samaneh Goorani
Masood Khani
Maryam Kamarehei
Amir Hossein Kiani
Publikationsdatum
01.02.2015
Verlag
Springer US
Erschienen in
Inflammation / Ausgabe 1/2015
Print ISSN: 0360-3997
Elektronische ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-014-0023-y

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