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Erschienen in: Breast Cancer Research and Treatment 3/2019

03.05.2019 | Preclinical study

Elevated serum levels of sialyl Lewis X (sLeX) and inflammatory mediators in patients with breast cancer

verfasst von: Evan N. Cohen, Tamer M. Fouad, Bang-Ning Lee, Banu K. Arun, Diane Liu, Sanda Tin, Angelica M. Gutierrez Barrera, Toshihide Miura, Iwao Kiyokawa, Jun Yamashita, Ricardo H. Alvarez, Vicente Valero, Wendy A. Woodward, Yu Shen, Naoto T. Ueno, Massimo Cristofanilli, James M. Reuben

Erschienen in: Breast Cancer Research and Treatment | Ausgabe 3/2019

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Abstract

Purpose

The carbohydrate sialyl LewisX (sLeX) mediates cell adhesion, is critical in the normal function of immune cells, and is frequently over-expressed on cancer cells. We assessed the association, differential levels, and prognostic value of sLeX and inflammatory cytokines/chemokines in breast cancer sera.

Methods

We retrospectively measured sLeX and a panel of cytokines/chemokines in the sera of 26 non-invasive ductal carcinoma in situ (DCIS), 154 invasive non-metastatic breast cancer (non-MBC), 63 metastatic breast cancer (MBC) patients, and 43 healthy controls. Differences in sLeX and inflammatory cytokines among and between patient groups and healthy controls were assessed with nonparametric tests and we performed survival analysis for the prognostic potential of sLeX using a cut-off of 8 U/mL as previously defined.

Results

Median serum sLeX was significantly higher than controls for invasive breast cancer patients (MBC and non-MBC) but not DCIS. In univariate analysis, we confirmed patients with serum sLeX > 8 U/mL have a significantly shorter progression-free survival (PFS) (P = 0.0074) and overall survival (OS (P = 0.0003). Similarly, patients with high serum MCP-1 and IP-10 had shorter OS (P = 0.001 and P < 0.001, respectively) and PFS (P = 0.010 and P < 0.001, respectively). sLeX, MCP-1 and IP-10 remained significant in multivariate survival analysis.

Conclusion

Elevated serum sLeX was associated with invasive cancer but not DCIS. High serum sLeX levels were associated with inflammatory mediators and may play a role in facilitating local invasion of breast tumor. Furthermore, serum MCP-1, IP-10 and sLeX may have prognostic value in breast cancer.
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Metadaten
Titel
Elevated serum levels of sialyl Lewis X (sLeX) and inflammatory mediators in patients with breast cancer
verfasst von
Evan N. Cohen
Tamer M. Fouad
Bang-Ning Lee
Banu K. Arun
Diane Liu
Sanda Tin
Angelica M. Gutierrez Barrera
Toshihide Miura
Iwao Kiyokawa
Jun Yamashita
Ricardo H. Alvarez
Vicente Valero
Wendy A. Woodward
Yu Shen
Naoto T. Ueno
Massimo Cristofanilli
James M. Reuben
Publikationsdatum
03.05.2019
Verlag
Springer US
Erschienen in
Breast Cancer Research and Treatment / Ausgabe 3/2019
Print ISSN: 0167-6806
Elektronische ISSN: 1573-7217
DOI
https://doi.org/10.1007/s10549-019-05258-0

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