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01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Journal of Cardiothoracic Surgery 1/2014

Elevation of serum lactate dehydrogenase in patients with pectus excavatum

Journal of Cardiothoracic Surgery > Ausgabe 1/2014
Jae Jun Kim, Chi Kyeong Kim, Hyung Joo Park, Jae Kil Park, Seok Whan Moon, Young Kyu Moon, Hyun Jung Kim
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1749-8090-9-75) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

JK carried out overall study design, data collection, the statistical analysis, and drafted the manuscript. CK carried out overall review of the paper and helped to draft the manuscript. HP participated in data collection. JP participated in data collection. SM, MY and HK participated in study design. All authors read and approved the final manuscript.



Pectus excavatum is the most common congenital chest wall deformity and the depression of the anterior chest wall, which compresses the internal organs. The aim of the present study is to investigate the effects of pectus excavatum on blood laboratory findings.

Material and Methods

From March 2011 to December 2011, 71 patients with pectus excavatum who visited Seoul Saint Mary Hospital for Nuss procedure were reviewed and analyzed. The blood samples were routinely taken at the day before surgery and pectus bar removal was usually performed in 2 to 3 years after Nuss procedure. To investigate the effects on blood laboratory findings, preoperative routine blood laboratory data and postoperative changes of abnormal laboratory data were analyzed.


Only lactate dehydrogenase (LDH), one of 26 separate routine laboratory tests, was abnormal and significantly elevated than normal value (age <10, p = 0.008; age ≥10, p < 0.001). However, there was no significant correlation between LDH levels and severities of pectus excavatum. The symmetric subgroup had significantly higher LDH level than the asymmetric subgroup (p <0.001) and there was a significant decrease of LDH level after correction of deformity (p = 0.017).


In conclusion, only LDH, one of the routine laboratory tests, was significantly elevated than normal value, which was thought to be caused by etiologies of pectus excavatum and the compression of the internal organs. Further studies on LDH including isoenzyme studies in patients with pectus excavatum will be needed, and these studies will provide a deeper and wider comprehension of pectus excavatum.
Authors’ original file for figure 1
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