Skip to main content
Erschienen in: Current Fungal Infection Reports 4/2018

18.10.2018 | Clinical Mycology Lab Issues (S Córdoba, Section Editor)

Emergence of Resistance to Fluconazole in Candida albicans Isolated From Vaginal Discharge

verfasst von: Susana Córdoba, Constanza Taverna, Walter Vivot, Wanda Szusz, Matias Vivot, Guillermina Isla, Graciela Davel

Erschienen in: Current Fungal Infection Reports | Ausgabe 4/2018

Einloggen, um Zugang zu erhalten

Abstract

Purpose of Review

To provide information about the emergence of fluconazole resistance in Candida albicans isolated from vaginal discharge, in a global context, and to update the in vitro susceptibility profile of this species from Argentina.

Recent Findings

Vulvovaginal candidiasis is the second most common vaginal infection after vaginal bacteriosis. C. albicans remains the prevalent etiological yeast species, and despite antifungal treatment, the rate of recurrence remains high, which may be associated to antifungal resistance.

Summary

Data here presented were obtained from the study of C. albicans strains isolated from patients with clinical signs of vulvovaginal candidiasis from 1996 to 2017. Data obtained could represent the susceptibility profile of C. albicans strains circulating in Argentina and could be of potential usefulness to monitor and guide therapy, and also suggests the need for greater surveillance programs to detect fluconazole resistance over time.
Literatur
2.
Zurück zum Zitat Negroni R, Arechavala AI, Bianchi MH, Robles AM. Problemas clínicos en Micología Médica: problema no. 33. Rev Iberoam Micol. 2008;25:196–8.CrossRef Negroni R, Arechavala AI, Bianchi MH, Robles AM. Problemas clínicos en Micología Médica: problema no. 33. Rev Iberoam Micol. 2008;25:196–8.CrossRef
5.
Zurück zum Zitat Mendling W, Brasch J, Guideline vulvovaginal candidosis. (2010)of the German Society for Gynecology and Obstetrics, the Working Group for Infections and Infectimmunology in Gynecology and Obstetrics, the German Society of Dermatology, the Board of German Dermatologists and the German Speaking Mycological Society. Mycoses. 2012;55(Suppl 3):1–13. https://doi.org/10.1111/j.1439-0507.2012.02185.x.CrossRefPubMed Mendling W, Brasch J, Guideline vulvovaginal candidosis. (2010)of the German Society for Gynecology and Obstetrics, the Working Group for Infections and Infectimmunology in Gynecology and Obstetrics, the German Society of Dermatology, the Board of German Dermatologists and the German Speaking Mycological Society. Mycoses. 2012;55(Suppl 3):1–13. https://​doi.​org/​10.​1111/​j.​1439-0507.​2012.​02185.​x.CrossRefPubMed
6.
Zurück zum Zitat Matheson A, Mazza D. Recurrent vulvovaginal candidasis: a review of guideline recommendations. Aust N Z J Obstet Gynaecol. 2017;57:139–45.CrossRef Matheson A, Mazza D. Recurrent vulvovaginal candidasis: a review of guideline recommendations. Aust N Z J Obstet Gynaecol. 2017;57:139–45.CrossRef
8.
Zurück zum Zitat Corsello S, Spinillo A, Osnengo G, Penna C, Guaschino S, Beltrame A, et al. An epidemiological survey of vulvovaginal candidiasis in Italy. Eur J Obstet Gynecol Reprod Biol. 2003;110:66–72.CrossRef Corsello S, Spinillo A, Osnengo G, Penna C, Guaschino S, Beltrame A, et al. An epidemiological survey of vulvovaginal candidiasis in Italy. Eur J Obstet Gynecol Reprod Biol. 2003;110:66–72.CrossRef
10.
Zurück zum Zitat Foxman B, Muraglia R, Dietz JP, Sobel JD, Wagner J. Prevalence of recurrent vulvovaginal candidiasis in 5 European countries and the United States: results from an internet panel survey. J Low Genit Tract Dis. 2013;17:340–5 9.CrossRef Foxman B, Muraglia R, Dietz JP, Sobel JD, Wagner J. Prevalence of recurrent vulvovaginal candidiasis in 5 European countries and the United States: results from an internet panel survey. J Low Genit Tract Dis. 2013;17:340–5 9.CrossRef
11.
Zurück zum Zitat Aballea S, Guelfucci F, Wagner J, Khemiri A, Dietz JP, Sobel JD, et al. Subjective health status and health-related quality of life among women with recurrent vulvovaginal candidosis (RVVC) in Europe and the USA. Health Qual Life Outcomes. 2013;11:169.CrossRef Aballea S, Guelfucci F, Wagner J, Khemiri A, Dietz JP, Sobel JD, et al. Subjective health status and health-related quality of life among women with recurrent vulvovaginal candidosis (RVVC) in Europe and the USA. Health Qual Life Outcomes. 2013;11:169.CrossRef
12.
Zurück zum Zitat •• Bader O. Fungal species identification by MALDI-ToF mass spectrometry. Methods Mol Biol Clifton NJ. 2017;1508:323–37 Describes the usefulness of this technique to identify fungal species. CrossRef •• Bader O. Fungal species identification by MALDI-ToF mass spectrometry. Methods Mol Biol Clifton NJ. 2017;1508:323–37 Describes the usefulness of this technique to identify fungal species. CrossRef
13.
Zurück zum Zitat Romeo O, Criseo G. Candida africana and its closest relatives. Mycoses. 2010;54:475–86.CrossRef Romeo O, Criseo G. Candida africana and its closest relatives. Mycoses. 2010;54:475–86.CrossRef
14.
Zurück zum Zitat Croxatto A, Prod’hom G, Greub G. Applications of MALDI-TOF mass spectrometry in clinical diagnostic microbiology. FEMS Microbiol Rev. 2012;36:380–407.CrossRef Croxatto A, Prod’hom G, Greub G. Applications of MALDI-TOF mass spectrometry in clinical diagnostic microbiology. FEMS Microbiol Rev. 2012;36:380–407.CrossRef
19.
Zurück zum Zitat • Hazirolan G, Altun HU, Gumral R, Gursoy NC, Otlu B, Sancak B. Prevalence of Candida africana and Candida dubliniensis, in vulvovaginal candidiasis: first Turkish Candida africana isolates from vulvovaginal candidiasis. J Mycol Med. 2017;27:376–81. https://doi.org/10.1016/j.mycmed.2017.04.106 Describes cryptic species that belong to Candida albicans species complex. CrossRefPubMed • Hazirolan G, Altun HU, Gumral R, Gursoy NC, Otlu B, Sancak B. Prevalence of Candida africana and Candida dubliniensis, in vulvovaginal candidiasis: first Turkish Candida africana isolates from vulvovaginal candidiasis. J Mycol Med. 2017;27:376–81. https://​doi.​org/​10.​1016/​j.​mycmed.​2017.​04.​106 Describes cryptic species that belong to Candida albicans species complex. CrossRefPubMed
20.
Zurück zum Zitat • Theill L, Dudiuk C, Morano S, Gamarra S, Nardin ME, Méndez E, et al. Prevalence and antifungal susceptibility of Candida albicans and its related species Candida dubliniensis and Candida africana isolated from vulvovaginal samples in a hospital of Argentina. Rev Argent Microbiol. 2016;48:43–9 Describes cryptic species that belong to Candida albicans species complex and their antifungal susceptibility profile. PubMed • Theill L, Dudiuk C, Morano S, Gamarra S, Nardin ME, Méndez E, et al. Prevalence and antifungal susceptibility of Candida albicans and its related species Candida dubliniensis and Candida africana isolated from vulvovaginal samples in a hospital of Argentina. Rev Argent Microbiol. 2016;48:43–9 Describes cryptic species that belong to Candida albicans species complex and their antifungal susceptibility profile. PubMed
21.
Zurück zum Zitat •• Pappas PG, Kauffman CA, Andes DR, Clancy CJ, Marr KA, Ostrosky-Zeichner L, et al. Clinical practice guideline for the management of Candidiasis 2016 update by the Infectious Diseases Society of America. Clin Infect Dis. 2016;62:e1–50. https://doi.org/10.1093/cid/civ933 Current Guideline for antifungal treatment. CrossRefPubMed •• Pappas PG, Kauffman CA, Andes DR, Clancy CJ, Marr KA, Ostrosky-Zeichner L, et al. Clinical practice guideline for the management of Candidiasis 2016 update by the Infectious Diseases Society of America. Clin Infect Dis. 2016;62:e1–50. https://​doi.​org/​10.​1093/​cid/​civ933 Current Guideline for antifungal treatment. CrossRefPubMed
22.
Zurück zum Zitat Watson C, Pirotta M. Recurrent vulvovaginal candidiasis: current management. Aust Fam Physician. 2011;40:149–51.PubMed Watson C, Pirotta M. Recurrent vulvovaginal candidiasis: current management. Aust Fam Physician. 2011;40:149–51.PubMed
23.
Zurück zum Zitat Miró MS, Rodríguez E, Vigezzi C, Icely PA, Gonzaga de Freitas Araújo M, Riera FO, et al. Vulvovaginal candidiasis: an old disease with new challenges. Rev Iberoam Micol. 2017;34:65–71.CrossRef Miró MS, Rodríguez E, Vigezzi C, Icely PA, Gonzaga de Freitas Araújo M, Riera FO, et al. Vulvovaginal candidiasis: an old disease with new challenges. Rev Iberoam Micol. 2017;34:65–71.CrossRef
24.
Zurück zum Zitat White TC, Marr KA, Bowden RA. Clinical, cellular, and molecular factors that contribute to antifungal drug resistance. Clin Microbiol Rev. 1998;11:382–402.CrossRef White TC, Marr KA, Bowden RA. Clinical, cellular, and molecular factors that contribute to antifungal drug resistance. Clin Microbiol Rev. 1998;11:382–402.CrossRef
28.
Zurück zum Zitat Wang FJ, Zhang D, Liu ZH, Wu WX, Bai HH, Dong HY. Species distribution and in vitro antifungal susceptibility of vulvovaginal Candida isolates in China. Chin Med J. 2016;129:1161–5.CrossRef Wang FJ, Zhang D, Liu ZH, Wu WX, Bai HH, Dong HY. Species distribution and in vitro antifungal susceptibility of vulvovaginal Candida isolates in China. Chin Med J. 2016;129:1161–5.CrossRef
30.
Zurück zum Zitat Feng LJ, Wan Z, Wang XH, Li RY, Liu W. Relationship between antifungal resistance of fluconazole resistant Candida albicans and mutations in ERG11 gene. Chin Med J. 2010;123:544–8.PubMed Feng LJ, Wan Z, Wang XH, Li RY, Liu W. Relationship between antifungal resistance of fluconazole resistant Candida albicans and mutations in ERG11 gene. Chin Med J. 2010;123:544–8.PubMed
31.
Zurück zum Zitat Chen LM, Xu YH, Zhou CL, Zhao J, Li CY, Wang RJ. Overexpression of CDR1 and CDR2 genes plays an important role in fluconazole resistance in Candida albicans with G487T and T916C mutations. Int Med Res. 2010;38(2):536–45.CrossRef Chen LM, Xu YH, Zhou CL, Zhao J, Li CY, Wang RJ. Overexpression of CDR1 and CDR2 genes plays an important role in fluconazole resistance in Candida albicans with G487T and T916C mutations. Int Med Res. 2010;38(2):536–45.CrossRef
32.
Zurück zum Zitat Zhao J, Xu Y, Li C. Association of T916C (Y257H) mutation in Candida albicans ERG11 with fluconazole resistance. Mycoses. 2013;56:315–20.CrossRef Zhao J, Xu Y, Li C. Association of T916C (Y257H) mutation in Candida albicans ERG11 with fluconazole resistance. Mycoses. 2013;56:315–20.CrossRef
33.
Zurück zum Zitat •• Liu JY, Shi C, Wang Y, Li WJ, Zhao Y, Xiang MJ. Mechanisms of azole resistance in Candida albicans clinical isolates from Shanghai, China. Res Microbiol. 2015;166:153–61 Describes the molecular mechanisms of fluconazole resistance. CrossRef •• Liu JY, Shi C, Wang Y, Li WJ, Zhao Y, Xiang MJ. Mechanisms of azole resistance in Candida albicans clinical isolates from Shanghai, China. Res Microbiol. 2015;166:153–61 Describes the molecular mechanisms of fluconazole resistance. CrossRef
34.
Zurück zum Zitat •• Khosravi Rad K, Falahati M, Roudbary M, Farahyar S, Nami S. Overexpression of MDR-1 and CDR-2 genes in fluconazole resistance of Candida albicans isolated from patients with vulvovaginal candidiasis. Curr Med Mycol. 2016;2(4):24–9 Describes the molecular mechanisms of fluconazole resistance. CrossRef •• Khosravi Rad K, Falahati M, Roudbary M, Farahyar S, Nami S. Overexpression of MDR-1 and CDR-2 genes in fluconazole resistance of Candida albicans isolated from patients with vulvovaginal candidiasis. Curr Med Mycol. 2016;2(4):24–9 Describes the molecular mechanisms of fluconazole resistance. CrossRef
39.
Zurück zum Zitat García Heredia M, García SD, Copolillo EF, Eliseth MC, Barata AD, Vay CA, et al. Prevalencia de candidiasis vaginal en embarazadas. Identificación de levaduras y sensibilidad a los antifúngicos. Rev Argent Microbiol. 2006;38:9–12.PubMed García Heredia M, García SD, Copolillo EF, Eliseth MC, Barata AD, Vay CA, et al. Prevalencia de candidiasis vaginal en embarazadas. Identificación de levaduras y sensibilidad a los antifúngicos. Rev Argent Microbiol. 2006;38:9–12.PubMed
40.
Zurück zum Zitat Arechavala AI, Bianchi MH, Robles AM, Santiso G, Negroni R. Identificación y sensibilidad frente a fluconazol y albaconazol de 100 cepas de levaduras aisladas de flujo vaginal. Rev Iberoam Micol. 2007;24:305–8.CrossRef Arechavala AI, Bianchi MH, Robles AM, Santiso G, Negroni R. Identificación y sensibilidad frente a fluconazol y albaconazol de 100 cepas de levaduras aisladas de flujo vaginal. Rev Iberoam Micol. 2007;24:305–8.CrossRef
42.
Zurück zum Zitat Muccia MJ, Cuestas ML, Landanburu MF, Mujica MT. Prevalence of Candida albicans, Candida dubliniensis and Candida africana in pregnant women suffering from vulvovaginal candidiasis in Argentina. Rev Iberoam Micol. 2017;34:72–6.CrossRef Muccia MJ, Cuestas ML, Landanburu MF, Mujica MT. Prevalence of Candida albicans, Candida dubliniensis and Candida africana in pregnant women suffering from vulvovaginal candidiasis in Argentina. Rev Iberoam Micol. 2017;34:72–6.CrossRef
44.
Zurück zum Zitat •• Arendrup MC, Meletiadis J, Mouton JW, Lagrou K, Hamal P, Guinea J, and the Subcommittee on Antifungal Susceptibility Testing (AFST) of the ESCMID European Committee for Antimicrobial Susceptibility Testing (EUCAST). EUCAST. Definitive document E.DEF 7.3.1. Method for the determination of broth dilution minimum inhibitory concentrations of antifungal agents for yeasts. January 2017. http://www.eucast.org. Reference document used in the present study. •• Arendrup MC, Meletiadis J, Mouton JW, Lagrou K, Hamal P, Guinea J, and the Subcommittee on Antifungal Susceptibility Testing (AFST) of the ESCMID European Committee for Antimicrobial Susceptibility Testing (EUCAST). EUCAST. Definitive document E.DEF 7.3.1. Method for the determination of broth dilution minimum inhibitory concentrations of antifungal agents for yeasts. January 2017. http://​www.​eucast.​org. Reference document used in the present study.
Metadaten
Titel
Emergence of Resistance to Fluconazole in Candida albicans Isolated From Vaginal Discharge
verfasst von
Susana Córdoba
Constanza Taverna
Walter Vivot
Wanda Szusz
Matias Vivot
Guillermina Isla
Graciela Davel
Publikationsdatum
18.10.2018
Verlag
Springer US
Erschienen in
Current Fungal Infection Reports / Ausgabe 4/2018
Print ISSN: 1936-3761
Elektronische ISSN: 1936-377X
DOI
https://doi.org/10.1007/s12281-018-0329-6

Weitere Artikel der Ausgabe 4/2018

Current Fungal Infection Reports 4/2018 Zur Ausgabe

Fungal Infections of Skin and Subcutaneous (A Bonifaz, Section Editor)

Association of Malassezia to Atopic Dermatitis

Clinical Mycology Lab Issues (S Córdoba, Section Editor)

Fungal Keratitis: Epidemiological Profile in Argentina

Current Management of Fungal Infections (J Maertens, Section Editor)

Diagnosing Invasive Mold Infections: What Is Next

Current Management of Fungal Infections (J Maertens, Section Editor)

Patients with Primary Immunodeficiencies: How Are They at Risk for Fungal Disease?

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.